Prognostic Factors in Myoepithelial Carcinoma of the Major Salivary Glands

Xiao, Christopher C.; Baker, Andrew B.; White‐Gilbertson, Shai; Day, Terry A.

doi:10.1177/0194599816637605

Cited by 20 publications

(24 citation statements)

References 17 publications

(41 reference statements)

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“…Cases occur over a wide age distribution with a mean age at diagnosis in the late 40s to early 50s . There is no gender predilection …”

Section: Malignant Neoplasmsmentioning

confidence: 99%

“…Up to a half of cases arise ex pleomorphic adenoma (PA), making MyoEpC the second most common malignant phenotype to emerge from PA. 103 Cases occur over a wide age distribution with a mean age at diagnosis in the late 40s to early 50s. [104][105][106] There is no gender predilection. [106][107][108] A number of molecular alterations have been identified in MyoEpCs.…”

Section: Myoepithelial Carcinomamentioning

confidence: 99%

“…[104][105][106] There is no gender predilection. [106][107][108] A number of molecular alterations have been identified in MyoEpCs.…”

Section: Myoepithelial Carcinomamentioning

confidence: 99%

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The key radiologic and cytomorphologic features of oncocytic and oncocytoid lesions of the salivary gland

Lubin

Song

Zafar

et al. 2019

Diagnostic Cytopathology

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Oncocytic and oncocytoid lesions represent a distinct subset of salivary gland lesions. True oncocytic lesions of the salivary gland are entirely composed of oncocytes. These are characterized by the presence of abundant eosinophilic granules due to the presence of abundant cytoplasmic mitochondria. Oncocytic lesions of the salivary gland include oncocytosis, oncocytoma, and oncocytic carcinoma. In addition to the true oncocytic lesion, there exists another group of salivary gland lesions, which demonstrate cells with abundant and occasionally granular cytoplasm. These are often termed as “oncocytoid” lesions. The recently proposed Milan System for reporting salivary gland cytology clearly states that fine‐needle aspiration specimens representing oncocytic/oncocytoid lesions of salivary gland cannot effectively distinguish between a nonneoplastic lesion, benign and malignant neoplasms. Therefore, most lesions lacking classic cytomorphologic features will be classified under the umbrella diagnostic term of “Salivary Gland Neoplasm of Uncertain Malignant Potential” (SUMP). In this review, we discuss and illustrate key clinicopathologic and radiologic features that can help the practicing cytopathologist narrow down the differential and provide the best management based diagnosis.

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“…Cases occur over a wide age distribution with a mean age at diagnosis in the late 40s to early 50s . There is no gender predilection …”

Section: Malignant Neoplasmsmentioning

confidence: 99%

Section: Myoepithelial Carcinomamentioning

confidence: 99%

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The key radiologic and cytomorphologic features of oncocytic and oncocytoid lesions of the salivary gland

Lubin

Song

Zafar

et al. 2019

Diagnostic Cytopathology

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“…There are no active systemic therapies for this cancer, rendering recurrent or metastatic disease generally incurable. The molecular alterations that define MECA have not been well characterized (1,2). In earlier studies, MECA constituted less than 2% of all salivary gland cancers, but its incidence is now believed to be higher due to increased recognition by pathologists (3).…”

Section: Introductionmentioning

confidence: 99%

“…MECAs most commonly arise in the parotid gland, followed by the submandibular and minor salivary glands (1). While most cases present as localized disease, advanced locoregional or distant recurrence is relatively common, leading to a 5-year overall survival rate of 64% (2).…”

Section: Introductionmentioning

confidence: 99%

Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions

Dalin

Katabi

Persson

et al. 2017

Preprint

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Myoepithelial carcinoma (MECA) is an aggressive type of salivary gland cancer with largely unknown molecular features. MECA may arise de novo or result from oncogenic transformation of a pre-existing pleomorphic adenoma (MECA ex-PA). We comprehensively analyzed the molecular alterations in MECA with integrated genomic analyses. We identified a low mutational load (0.5/MB), but a high prevalence of fusion oncogenes (28/40 tumors; 70%). We found FGFR1-PLAG1 in 7 (18%) cases, and the novel TGFBR3-PLAG1 fusion in 6 (15%) cases. TGFBR3-PLAG1 was specific for MECA de novo tumors or the malignant component of MECA ex-PA, was absent in 723 other salivary gland tumors, and promoted a tumorigenic phenotype in vitro.We discovered other novel PLAG1 fusions, including ND4-PLAG1, which is an oncogenic fusion between mitochondrial and nuclear DNA. One tumor harbored an MSN-ALK fusion, which was tumorigenic in vitro, and targetable with ALK inhibitors. Certain gene fusions were predicted to result in neoantigens with high MHC binding affinity. A high number of copy number alterations was associated with poorer prognosis. Our findings indicate that MECA is a fusion-driven disease, nominate TGFBR3-PLAG1 as a hallmark of MECA, and provide a framework for future steps of diagnostic and therapeutic research in this lethal cancer.

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Salivary Gland

Range¹

2019

Practical Head and Neck Pathology

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Prognostic Factors in Myoepithelial Carcinoma of the Major Salivary Glands

Abstract: The presence of regional nodal disease, high-grade disease, and advanced stage are predictors of lower survival in myoepithelial carcinoma. Further studies based on types of treatment are warranted.

Cited by 20 publications

References 17 publications

The key radiologic and cytomorphologic features of oncocytic and oncocytoid lesions of the salivary gland

The key radiologic and cytomorphologic features of oncocytic and oncocytoid lesions of the salivary gland

Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions

Salivary Gland

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