Prognostic factors in laryngeal squamous cell carcinoma

Bradford, Carol R.; Ferlito, Alfio; Devaney, Kenneth O.; Mäkitie, Antti; Rinaldo, Alessandra

doi:10.1002/lio2.353

Cited by 55 publications

(62 citation statements)

References 73 publications

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“…In the present study, multivariate analysis ( Tab. III ) confirmed that only a pathological finding of neck metastasis was an independent negative prognostic factor in terms of recurrence rate (p = 0.05), consistent with the current literature on laryngeal cancer 26 . On the other hand, the impaired arytenoid motility, CAU invasion and need for OPHL type III were not independent negative prognostic factors.…”

Section: Discussionsupporting

confidence: 88%

Modular approach in OPHL: are there preoperative predictors?

Bertolin

Lionello

Ghizzo

et al. 2020

Acta Otorhinolaryngol Ital

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SUMMARY Objective Open partial horizontal laryngectomies (OPHLs) nowadays represent the first line surgical choice for the conservative treatment of locally intermediate and selected advanced stage laryngeal cancers. Among the peculiarities of OPHLs, there is the possibility of intraoperatively modulating the procedure. It would be useful for the surgeon to recognise preoperative endoscopic and radiological factors that can predict the possibility to modulate the laryngectomy. Methods The present study retrospectively reviewed a cohort of 72 patients who underwent OPHL for glottic LSCC, in order to identify preoperative (endoscopic and radiological) parameters that are able to predict modulation surgery. Results The hypoglottic extension of the glottic tumour was the preoperative finding that was most informative in predicting OPHL modulation. However, it had no significant impact on oncological outcomes. Conclusions Patients affected by tumours with hypoglottic extension and eligible for OPHL type II should be preoperatively informed about the possibility of an intraoperative switch towards OPHL type III.

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Section: Discussionsupporting

confidence: 88%

Modular approach in OPHL: are there preoperative predictors?

Bertolin

Lionello

Ghizzo

et al. 2020

Acta Otorhinolaryngol Ital

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“…It includes a heterogenous group of patients with different outcomes, so more appropriate treatment modalities tailored to each case on its own should be offered. This necessitates patient stratification based on other prognostic factors to be added to the traditional, limited WHO grading system [ 3 , 13 ]. Tumor budding is a microscopic finding detected by light microscopy at the invasive front of tumors.…”

Section: Discussionmentioning

confidence: 99%

“…Concerning lymph node metastases, although the number, size and level of the invaded lymph nodes were considered important, yet extracapsular spread proved to be of exceedingly paramount prognostic importance [ 13 , 24 ]. Our current study showed a high statistical significance between tumor budding and extracapsular spread which highlights the probable prognostic value of tumor budding in laryngeal carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…However, our results were unlike Ekmekci et al [ 20 ] and Sarioglu et al [ 21 ], whose cases showed no statistical significance between lymph node extracapsular spread and tumor budding. Among important prognostic factors of laryngeal carcinoma are tumor grade and tumor site [ 13 ]. Unlike what was recorded by Ekmekci et al [ 20 ] and Boxberg et al [ 22 ], our cases showed a highly statistically significant relation between tumor budding and each of tumor grade and site ( p = 0.0001 for each).…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the Potential Prognostic Value of Tumor Budding in Laryngeal Carcinoma by Conventional and Immunohistochemical Staining

Raboh

Mady

Hakim

2020

Analytical Cellular Pathology

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Background. Tumor budding is a promising prognostic indicator in several cancers especially in colorectal cancer. However, only few studies have been conducted to assess and validate its prognostic value in laryngeal squamous cell carcinoma; none of which used pancytokeratin immunohistochemistry. In view of the modest results of treatment of laryngeal squamous cell carcinoma, the need of new prognostic indicators becomes of paramount importance. Aim of the Study. We aim to evaluate tumor budding in laryngeal squamous cell carcinoma, by haematoxylin and eosin, as well as by pancytokeratin immunohistochemistry. Material and Methods. A retrospective study on 118 cases of laryngeal squamous cell carcinoma from archives of Pathology Lab of Ain Shams University Specialized Hospital and Ain Shams University Hospitals from January 2014 to January 2017. The ENT and histopathology reports were reviewed to determine clinicopathologic data of the patients. Results. Tumor budding shows high statistically significant relations ( p = 0.0001 for each) with important clinicopathological parameters of laryngeal carcinoma (site, grade, tumor stage, lymph node stage, lymph node extracapsular invasion, and vascular invasion). The extent of tumor budding correlated with overall survival, local recurrence disease free, and distant metastasis disease free ( p = 0.001 for each). Multivariate analysis showed tumor budding to be an independent prognostic factor affecting progression-free survival. There was a moderate agreement between H&E and IHC by pancytokeratin as regards detection of budding among study cases ( kappa = 0.593 ). Conclusions. Tumor budding was correlated with poor prognostic clinicopathologic indicators in laryngeal squamous cell carcinoma. It is recommended to use pancytokeratin immunohistochemistry to evaluate tumor budding in laryngeal squamous cell carcinoma especially in confusing cases.

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“…Multiple studies have shown the importance of several prognostic factors as predictors for organ preservation, treatment response, and outcomes in laryngeal cancer patients [ 55 , 56 , 57 ]. An area of interest is the pretreatment larynx function and his predictor value for response to RT or chemoradiation.…”

Section: Locally Advanced Stage (Iii–iv)mentioning

confidence: 99%

Emerging Concepts and Novel Strategies in Radiation Therapy for Laryngeal Cancer Management

Gamez

Blakaj

Zoller

et al. 2020

Cancers

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Laryngeal squamous cell carcinoma is the second most common head and neck cancer. Its pathogenesis is strongly associated with smoking. The management of this disease is challenging and mandates multidisciplinary care. Currently, accepted treatment modalities include surgery, radiation therapy, and chemotherapy—all focused on improving survival while preserving organ function. Despite changes in smoking patterns resulting in a declining incidence of laryngeal cancer, the overall outcomes for this disease have not improved in the recent past, likely due to changes in treatment patterns and treatment-related toxicities. Here, we review emerging concepts and novel strategies in the use of radiation therapy in the management of laryngeal squamous cell carcinoma that could improve the relationship between tumor control and normal tissue damage (therapeutic ratio).

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Prognostic factors in laryngeal squamous cell carcinoma

Cited by 55 publications

References 73 publications

Modular approach in OPHL: are there preoperative predictors?

Modular approach in OPHL: are there preoperative predictors?

Evaluation of the Potential Prognostic Value of Tumor Budding in Laryngeal Carcinoma by Conventional and Immunohistochemical Staining

Emerging Concepts and Novel Strategies in Radiation Therapy for Laryngeal Cancer Management

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