Prognostic Factors in Intraoral Squamous Cell Carcinoma: The Influence of Histologic Grade

Kademani, Deepak; Bell, R. Bryan; Bagheri, Shahrokh C.; Holmgren, Eric P.; Dierks, Eric J.; Potter, Bryce E.; Homer, L. D.

doi:10.1016/j.joms.2005.07.011

Cited by 255 publications

(225 citation statements)

References 16 publications

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“…Unfortunately, the increase in incidence has not been paralleled by the development of new therapeutic agents (Lasrado et al, 2014). In contrast to the measurable progress made in surgery, chemotherapy, and radiotherapy the survival rate has only elevated slightly, with the 5-year survival rate remaining at 50% over the past 30 years (Kademani et al, 2005). Patients with premalignant lesions and early tage cancers, if they get a chance to be diagnosed earlier, have a high rate of survival, however unfortunately oral cancer most often show off in advanced forms and a fatal fate predicted for the vast majority of Stages III and IV cases (Kim et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

DOX-MTX-NPs Augment p53 mRNA Expression in OSCC Model in Rat: Effects of IV and Oral Routes

Abbasi¹,

Khiavi²,

Amir³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy worldwide. Cancer development and progression require inactivation of tumor suppressor genes and activation of proto-oncogenes. The well recognized mechanism of action demonstrated for chemotherapeutic agents is induction of apoptosis via reactivation of p53. In this context, we evaluate the efficacy of IV and oral routes of our novel PH and temperature sensitive doxorubicin-methotrexate-loaded nanoparticles (DOX-MTX NP) in affecting p53 profile in an OSCC rat model. Methods: In this study, 120 male rats were divided into 8 groups of 15 animals each. The new formulated DOX-MTX NP and free doxorubicin were IV and orally given to rats with 4-nitroquinoline-1-oxide induced OSCC. Results: Results showed that both DOX and DOX-MTX-NP caused significant increase in mRNA levels of P53 compared to the untreated group (p<0.000). With both DOX and DOX-MTX NP, the IV mode was more effective than the oral (gavage) route (p<0.000). Surprisingly, in oral mode, p53 mRNA was not affected in DOX treated groups (p>0.05), Nonetheless, both IV and oral administration of MTX-DOX NP showed superior activity (~3 fold) over free DOX in reactivation of p53 in OSCC (p<0.000). The effectiveness of oral route in group treated with nanodrug accounts for the enhanced bioavailability of nanoparticulated DOX-MTX compared to free DOX. Moreover, in treated groups, tumor stage was markedly related to the amount of p53 mRNA (p<0.05). Conclusion: Both oral and IV application of our novel nanodrug possesses superior activity over free DOX-in up-regulation of p53 in a OSCC model and this increase in p53 level associated with less aggressive tumors in our study. Although, impressive results obtained with IV form of nanodrug (-21 fold increase in p53 mRNA level) but both forms of nanodrug are effective in OSCC, with less toxicity normal cells.

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Section: Introductionmentioning

confidence: 99%

DOX-MTX-NPs Augment p53 mRNA Expression in OSCC Model in Rat: Effects of IV and Oral Routes

Abbasi¹,

Khiavi²,

Amir³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…These tumors are associated with decreased survival rates. 12 There is still controversy in the literature about margin status.…”

Section: Introductionmentioning

confidence: 99%

Fatores prognósticos no carcinoma espinocelular de cavidade oral

Montoro

Hicz

Souza³

et al. 2008

Rev. Bras. Otorrinolaringol.

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Researchers have been looking for factors that can influence the prognosis of oral cancer, because its outcome is highly uncertain. Aim: To evaluate variables that can impact the survival rate of patients with squamous-cell carcinoma of the oral cavity. Material and Methods: Data analysis of 45 patients from January, 2001 to January, 2006. Survival rate curves have been estimated using the KaplanMeier method and they have been compared through the log-rank test and the Cox regression standard. Study design: Retrospective analysis. Results: Total five-year survival rate was of 39% fpr these patients. Only the neck metastases (p=0.017), postoperative radiotherapy (p=0.056) and diseased margin(p=0.004) variables had statistic relevance. Survival rate was lower in patients with neck metastases, margins involved and those who underwent postoperative radiotherapy, in other words, those with the most aggressive tumors. After adjustment, radiotherapy did not prove to be statistically relevant. It is likely that the survival rate of 39% was due to the high number of patients with metastasis (52%) and because the samples were mostly of tongue and mouth floor diseases (82%), which are the hardest to control. Conclusion: Neck metastases and diseased margins of oral cavity carcinomas are the prognostic factors that can most impact the survival rate.

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“…This tyrosine kinase receptor is connected to various downstream signaling targets involved in cellular proliferation, apoptosis, angiogenesis , invasion, and also metastasis. HER2 encoded by ERBB2 gene and is overexpressesd in over 80% of all HNSCC (Jones et al, 1992;Kim et al, 2001;Lippman and Hong, 2001;Kademani et al, 2005;Montoro et al, 2008;Sardari et al, 2012;Khademi et al, 2013). Combination chemotherapy and nanoparticle drug delivery put forwards significant promise in cancer treatment.…”

Section: New Formulated "Dox-mtx-loaded Nanoparticles" Downregulate Hmentioning

confidence: 99%

New formulated "DOX-MTX-loaded Nanoparticles" Down-regulate HER2 Gene Expression and Improve the Clinical Outcome in OSCCs Model in Rat: the Effect of IV and Oral Modalities

Abbasi

Amir²,

Hamishehkar³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Oral squamous cell carcinoma (OSCC) remains as one of the most difficult malignancies to control because of its high propensity for local invasion and cervical lymph node dissemination. In this study, we evaluate the efficacy of our novel pH and temperature sensitive doxorubicin-methotrexate-loaded nanoparticles (DOX-MTX NP) in affecting HER2 expression profile in OSCC model in rat. Results: DOX-MTX-nanoparticle complexes caused significant decrease in mRNA level of HER2 compared to untreated cancers (p<0.05) and this finding was more pronounced with the IV mode (p<0.000). Surprisingly, HER2 mRNA was not affected in DOX treated as compared to the control group (p>0.05). On the other hand, in the DOX-MTX NP treated group, fewer tumors characterized with advanced stage and decreased HER2 paralleled improved clinical outcome (P<0.05). Moreover, the effectiveness of the oral route in the group treated with nanodrug accounted for the enhanced bioavailability of nanoparticulated DOX-MTX compared to free DOX. Furthermore, there was no significant difference in mRNA level of HER2 (p>0.05). Conclusions: Influence of HER2 gene expression is a new feature and mechanism of action observed only in dual action DOX-MTX-NPs treated groups. Down-regulation of HER2 mRNA as a promising marker and prognosticator of OSCC adds to the cytotoxic benefits of DOX in its new formulation. Both oral and IV application of this nanodrug could be used, with no preferences in term of their safety or toxicity. As HER2 is expressed abundantly by a wide spectrum of tumors, i DOX-MTX NPs may be useful for a wide-spectrum of lesions. However, molecular mechanisms underlying HER2 down regulation induced by DOX-MTX NPs remain to be addressed.

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Prognostic Factors in Intraoral Squamous Cell Carcinoma: The Influence of Histologic Grade

Cited by 255 publications

References 16 publications

DOX-MTX-NPs Augment p53 mRNA Expression in OSCC Model in Rat: Effects of IV and Oral Routes

DOX-MTX-NPs Augment p53 mRNA Expression in OSCC Model in Rat: Effects of IV and Oral Routes

Fatores prognósticos no carcinoma espinocelular de cavidade oral

New formulated "DOX-MTX-loaded Nanoparticles" Down-regulate HER2 Gene Expression and Improve the Clinical Outcome in OSCCs Model in Rat: the Effect of IV and Oral Modalities

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