Prognostic factors in inflammatory breast cancer and therapeutic implications

Palangié, T; Mosseri, Véronique; Mihura, J.; Campana, F.; Beuzeboc, Philippe; Dorval, Thierry; García-Giralt, E; Jouve, M; Scholl, Susy; Asselain, Bernard; Pouillart, P

doi:10.1016/0959-8049(94)90115-5

Cited by 74 publications

(49 citation statements)

References 17 publications

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“…Inflammatory breast carcinoma (IBC) is an aggressive form of human breast cancer characterized by florid lymphovascular invasion (LVI) and early metastasis (Palangie et al, 1994;Cariati et al, 2005). LVI is considered a rate-limiting step in the metastatic process and is characterized by tumor emboli within lymphovascular channels.…”

Section: Introductionmentioning

confidence: 99%

The lymphovascular embolus of inflammatory breast cancer exhibits a Notch 3 addiction

Xiao

Zou

et al. 2010

Oncogene

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Section: Introductionmentioning

confidence: 99%

The lymphovascular embolus of inflammatory breast cancer exhibits a Notch 3 addiction

Xiao

Zou

et al. 2010

Oncogene

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“…The presence of cytokines and inflammatory cells in cancer stroma, indicating defence reaction against cancer, generally correspond to a poor prognosis (Kleer et al, 2000). Furthermore, in breast cancer, initial presentation with clinical symptoms of inflammation indicates a particular aggressiveness and a worst prognosis than other breast cancers (Chevallier, 1993;Palangie et al, 1994;Kleer et al, 2000). However, the mechanisms leading to the pathological action of stroma-localised inflammatory cells in cancer, such as monocytes, remain poorly understood.…”

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confidence: 99%

Cooperation between monocytes and breast cancer cells promotes factors involved in cancer aggressiveness

Blot

Chen

Vasse³

et al. 2003

Br J Cancer

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In breast cancers, clinical symptoms of inflammation localised around the tumour at the time of diagnosis have been considered to have poor prognosis significance. In this study, the biological mechanisms responsible for the deleterious action of monocytes in cancer were investigated. The incubation of the breast-cancer-derived MDA-MB231 cells with monocytes resulted in an increase in factors involved in cell invasion (i.e. both cancer cells and monocytes-associated urokinase and Tissue Factor, and PAI-1 and MMP-9 secretion). Moreover, the functions of monocytes were also modified. Incubation of monocytes with MDA-MB231 cancer cells resulted in a downregulation in the secretion of the antiproliferative cytokine Oncostatin M, while the apoptotic factor TNF alpha was dramatically increased. However, MDA-MB231 cancer cells have been shown to be resistant towards the apoptotic action of TNF alpha. These findings demonstrate that incubation of MDA-MB231 cancer cells with monocytes induced a crosstalk, which resulted in an increased expression of factors involved in cancer cell invasiveness and in a modification of monocytes function against cancer cells, while inflammatory effects were increased. British Journal of Cancer (2003) The importance of stroma in cancer formation, growth and dissemination is now well established. In order to generate an invasive tumour, cancer cells need several mutations, but also formally necessitate sustenance from noncancer stroma cells, which supply and permit cancer cell growth and invasion. The presence of cytokines and inflammatory cells in cancer stroma, indicating defence reaction against cancer, generally correspond to a poor prognosis (Kleer et al, 2000). Furthermore, in breast cancer, initial presentation with clinical symptoms of inflammation indicates a particular aggressiveness and a worst prognosis than other breast cancers (Chevallier, 1993;Palangie et al, 1994;Kleer et al, 2000). However, the mechanisms leading to the pathological action of stroma-localised inflammatory cells in cancer, such as monocytes, remain poorly understood.The current study was undertaken to explore whether the factors of aggressiveness expressed by cancer cells were modified in the presence of monocytes. We also analysed the consequences of the incubation of monocytes with MDA-MB231 cancer cells on functions of monocytes both in the defence against tumour cells and in inflammatory functions. For this purpose, we tested the consequences of the interaction of the highly invasive breastderived MDA-MB231 cancer cells with monocytes with an in vitro system. MATERIAL AND METHODS Monocytes isolationA measure of 80 mm of blood from healthy volunteers was collected in sterile polypropylene tubes (Costar, Cambridge, MA, USA) containing 7.5 ml of ACD (38 mM citric acid, 74 mM citrate and 136 mM glucose). Platelet-rich plasma was removed by centrifugation (10 min, 100 g at room temperature). Mononuclear cells were collected after centrifugation (45 min, 400 g at room temperature) in Leucosep tubes (Costar, C...

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“…1 One telltale sign of lack of organ confinement is the presence of lymphovascular invasion, a finding that is most pronounced in IBC. 2 Lymphovascular invasion is defined by tumor emboli within lymphovascular spaces.…”

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confidence: 99%

Relationship of Sialyl-Lewisx/a Underexpression and E-Cadherin Overexpression in the Lymphovascular Embolus of Inflammatory Breast Carcinoma

Alpaugh

Tomlinson

Yin

et al. 2002

The American Journal of Pathology

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Inflammatory breast carcinoma (IBC) isOur screening methods for certain types of breast cancer such as inflammatory breast cancer (IBC) have not impacted the disease's age-adjusted 5 year mortality because these types of breast cancer do not remain organconfined before they are detected. 1 One telltale sign of lack of organ confinement is the presence of lymphovascular invasion, a finding that is most pronounced in IBC. 2 Lymphovascular invasion is defined by tumor emboli within lymphovascular spaces. 3 These emboli have a unique microscopic appearance of compact clumps of tumor cells retracted away from the surrounding endothelial cell layer lining the lymphovascular space. The molecular determinants of this phenotype remain undefined. Recently our laboratory established a human SCID model of IBC (MARY-X) that exhibited florid lymphovascular tumor emboli in vivo and compact spheroids in vitro. 4,5 We have characterized, in part, the molecular basis of the IBC phenotype using this model. Our initial studies indicated that MARY-X overexpressed both Ecadherin and MUC1. 4 We chose to focus on E-cadherin initially and demonstrated that both the tumor cell emboli and the in vitro spheroids formed on the basis of an intact and overexpressed E-cadherin/␣,␤-catenin axis that mediated tumor cell adhesion analogous to the embryonic blastocyst. 5 Disruption of the E-cadherin/␣,␤-catenin axis with either anti-E-cadherin antibodies or E-cadherin dominant-negative mutant approaches caused complete disadherence of the tumor emboli in vivo. Furthermore in addition to these two manipulations, trypsin proteolysis and Ca ϩϩ depletion caused complete disadherence of the spheroids in vitro. In the present study we decided to investigate the role of overexpressed MUC1 and a possible mechanism that might explain the apparent lack of binding of the tumor embolus to the surrounding endothelium.

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Prognostic factors in inflammatory breast cancer and therapeutic implications

Cited by 74 publications

References 17 publications

The lymphovascular embolus of inflammatory breast cancer exhibits a Notch 3 addiction

The lymphovascular embolus of inflammatory breast cancer exhibits a Notch 3 addiction

Cooperation between monocytes and breast cancer cells promotes factors involved in cancer aggressiveness

Relationship of Sialyl-Lewisx/a Underexpression and E-Cadherin Overexpression in the Lymphovascular Embolus of Inflammatory Breast Carcinoma

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