Prognostic factors in glottic carcinoma clinical stage I and II treated by surgery or radiotherapy

Impact of Anterior Commissure Involvement on Local Control of Early Glottic Carcinoma Treated by Laser Microresection

“…However, the impact of anterior commissure involvement on the success of primary radiotherapy is less clear. Some investigators 15–20 could not show an association between anterior commissure involvement and an increased risk of local recurrence. Thus, primary radiotherapy seems to be an effective and voice‐preserving treatment modality for glottic tumors involving the anterior commissure 21 .…”

Does Acid Suppressive Therapy Reduce the Risk of Laryngeal Cancer Recurrence?

“…Potential causes of recurrence include stage of tumor, nodal status of disease, and positive surgical margins, 7,9,10 and presence of continued smoking after initial therapy 6,10 . The risk of recurrence with the choice of initial therapy between surgery and radiotherapy for laryngeal cancer was shown to differ significantly in one study, 7 whereas no difference was found in another study 11 . A few anecdotal reports in the literature suggest that treatment with acid suppressive therapy may lead to decreased frequency of recurrences of laryngeal cancers 12,13 …”

“…6,10 The risk of recurrence with the choice of initial therapy between surgery and radiotherapy for laryngeal cancer was shown to differ significantly in one study, 7 whereas no difference was found in another study. 11 A few anecdotal reports in the literature suggest that treatment with acid suppressive therapy may lead to decreased frequency of recurrences of laryngeal cancers. 12,13 To the best of our knowledge, no study in the literature has systematically evaluated the role of gastroesophageal reflux disease (GERD) and acid suppressive therapy in laryngeal cancer recurrence.…”

TIMP3 and CCNA1 hypermethylation in HNSCC is associated with an increased incidence of second primary tumors

“…With an incidence of 17-30% and an annual risk of 3-10% [4-6], the development of SPT significantly contributes to a worse prognosis and cancer-associated death for HNSCC patients [4,7-10]. The SPT development is in accordance with the field cancerization theory, which refers to the presence of malignant or premalignant changes in the entire apparently normal mucosa in response to carcinogen exposition, especially tobacco and alcohol [11].…”