Prognostic factors in dogs with protein-losing enteropathy

Nakashima, Ko; Hiyoshi, Saaya; Ohno, Koichi; Uchida, Kazuyuki; Goto‐Koshino, Yuko; Maeda, Shingo; Mizutani, Noriyuki; Takeuchi, Ayano; Tsujimoto, Hajime

doi:10.1016/j.tvjl.2015.05.001

Cited by 56 publications

(108 citation statements)

References 12 publications

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“…Our results also indicated age as a useful indicator for predicting patient responsiveness to an ULFD. A previous study showed that dogs diagnosed with IL tend to be younger than those with chronic enteropathy, small cell lymphoma, or large cell lymphoma . Considering that dogs with primary IL tend to be young and responsive to ULFD, we speculate that the dogs with FR‐PLE in our study in fact may have had primary IL even though not every responder showed lacteal dilatation on histopathology.…”

Section: Discussionmentioning

confidence: 73%

“…A previous study showed that dogs diagnosed with IL tend to be younger than those with chronic enteropathy, small cell lymphoma, or large cell lymphoma . Considering that dogs with primary IL tend to be young and responsive to ULFD, we speculate that the dogs with FR‐PLE in our study in fact may have had primary IL even though not every responder showed lacteal dilatation on histopathology. Considering the limitations of endoscopic tissue biopsy samples for the diagnosis of IL, structural lesions might have been present in the deeper mucosa or distal jejunum, or might have been artificially altered during the collection, which may have led to an underestimation of IL .…”

Section: Discussionmentioning

confidence: 73%

“…Compared to the IR/NR‐PLE group, the FR‐PLE group had longer survival times, indicating that differentiating between these 2 groups of dogs with PLE based on responsiveness to the ULFD is important in predicting the prognosis. Because the FR‐PLE group had significantly lower CIBDAI and CCECAI scores than those found in the IR/NR‐PLE group, the longer survival time of the FR‐PLE group may be attributed to the severity of the disease, which has been shown to be associated with prognosis in dogs with PLE . In addition, other factors, such as body weight, BUN, ALB, and PARR could be associated with survival time .…”

Section: Discussionmentioning

confidence: 88%

“…Because the FR‐PLE group had significantly lower CIBDAI and CCECAI scores than those found in the IR/NR‐PLE group, the longer survival time of the FR‐PLE group may be attributed to the severity of the disease, which has been shown to be associated with prognosis in dogs with PLE . In addition, other factors, such as body weight, BUN, ALB, and PARR could be associated with survival time . Therefore, further study is needed to evaluate the effect of ULFD itself on the prognosis of dogs with PLE.…”

Section: Discussionmentioning

confidence: 98%

“…There is limited information on the effect of diet on dogs with PLE because these dogs typically show severe clinical signs and are expected to have a guarded prognosis with rapid progression . An exception is management using a fat‐restricted diet for dogs with primary IL .…”

Section: Introductionmentioning

confidence: 99%

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Clinical characteristics of dogs with food‐responsive protein‐losing enteropathy

Nagata

Ohta

Yokoyama

et al. 2020

Veterinary Internal Medicne

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Background In dogs with protein‐losing enteropathy (PLE), data on the clinical characteristics of food‐responsive PLE (FR‐PLE) remain scarce. Objective To determine the clinical characteristics of FR‐PLE in dogs responsive to ultralow‐fat diet (ULFD) management. Animals Thirty‐three dogs diagnosed with PLE based on standard diagnostic criteria. Methods Retrospective review of medical records. Clinical findings were compared between dogs with FR‐PLE (FR‐PLE group) and those with immunosuppressant‐responsive PLE (IR‐PLE) or nonresponsive PLE (NR‐PLE) (IR/NR‐PLE group). The area under the curve (AUC) of a receiver operating characteristic curve was used to evaluate the ability of factors to differentiate the FR‐PLE and IR/NR‐PLE groups. Survival time was compared between the FR‐PLE and IR/NR‐PLE groups. Results Twenty‐three dogs responded to ULFD management and were diagnosed with FR‐PLE. The canine chronic enteropathy clinical activity index (CCECAI) was significantly lower in the FR‐PLE group than in the IR/NR‐PLE group (P < .001). The AUC of CCECAI for differentiating the FR‐PLE group was 0.935 (95% confidence interval [CI], 0.845‐1.000) with an optimal cutoff value of 8 (sensitivity, 0.826; specificity, 0.889). Survival times were significantly longer in the FR‐PLE group (median, not reached) than in the IR/NR‐PLE group (median, 432 days; P < .001). Conclusions and Clinical Importance Dogs that respond to ULFD management and are diagnosed with FR‐PLE are expected to have a favorable prognosis. Clinical scores, specifically the CCECAI, could be useful for differentiating FR‐PLE from IR‐PLE or NR‐PLE.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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