Prognostic Factors in Childhood and Adolescent Non-Hodgkin Lymphoma

Pillon, Marta; Xavier, Ana C.; Cairo, Mitchell S.

doi:10.1007/978-3-030-11769-6_11

Cited by 2 publications

(6 citation statements)

References 108 publications

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“…Some subgroups such as pediatric marjinal zone lymphoma, pediatric-type follicular lymphoma and mucosa-associated lymphoid tissue lymphoma are very rare NHL subgroups in childhood. [1][2][3] In our study, the main NHL subgroups were BL, DLBCL, and LBL. The rare NHL subgroups for children such as DLBCL: diffuse large B-cell lymphoma, LBL: lymphoblastic lymphoma, ALCL: anaplastic large cell lymphoma, PID: primary immune deficiency, *They were not included in the analysis.…”

Section: Multivariate Analysismentioning

confidence: 81%

“…[1] Important prognostic factors well-known to date are histopathological subtype, disease burden, extent of disease, stage, minimal disseminated disease, minimal residual disease, some cytogenetics and some molecular genetics. [1][2][3] Survival rates vary according to pathological subgroups. For example, in studies of the same group, it was reported as 90.8% for BL, 78.8% for ALCL and 65.1% for DLCBL.…”

Section: Multivariate Analysismentioning

confidence: 99%

“…Although the etiology of NHL is not exactly known, immunodeficiency (congenital or acquired), viral infections (Epstein Barr virus, human immune deficiency virus, human T-lymphotropic virus), some drugs (anti-cancer drugs or immunosuppressive drugs) and radiotherapy are known etiological factors. [1][2][3] There are two different important factors that distinguish childhood NHL from adult lymphoma. These are the histopathological type and the more frequent extranodal involvement.…”

Section: Multivariate Analysismentioning

confidence: 99%

“…Another important feature is that the survival rates are generally excellent with intensive chemotherapy protocols. [1][2][3] In children, the most common pathological subgroups are BL, LBL (T-or B-), DLBCL, and ALCL. Some subgroups such as pediatric marjinal zone lymphoma, pediatric-type follicular lymphoma and mucosa-associated lymphoid tissue lymphoma are very rare NHL subgroups in childhood.…”

Section: Multivariate Analysismentioning

confidence: 99%

“…[1,2] Important prognostic factors well-known to date are histopathological subtype, disease burden, extent of disease, stage, minimal disseminated disease, minimal residual disease, some cytogenetics and some molecular genetics. [1][2][3] The outcomes of childhood NLS have improved dramatically in last years. The survival rates have reached >90%.…”

Section: Introductionmentioning

confidence: 99%

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Hodgkin dışı lenfomalı çocukların klinik özelliklerinin, tedavi yaklaşımlarının ve tedavi sonuçlarının değerlendirilmesi

Kara

Uğraş

Ertan

et al. 2022

Journal of Contemporary Medicine

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Aim: To evaluate the demographic and clinical characteristics, treatment approaches and outcomes of our pediatric patients with non-Hodgkin lymphoma diagnosed and treated in our center. Material and Methods: Between 2006 and 2002, the oncologic charts of the patients diagnosed and followed up as non-Hodgkin lymphoma were reviewed retrospectively. Results: Eighty children with non-Hodgkin lymphoma were included in this study. There were 55 boys (68.8%) and 25 girls (31.2%). The patients’ ages ranged from 2 to 18 years (median: 11.1 years). Nine patients (11.3%) had primary immunodeficiency. Sixty-three of the patients were stage III (78.7%). The majority pathologic subtype was Burkitt lymphoma (n: 31, 38.8%). The overall survival and event-free survival rates were 71.7% and 71.5%, respectively. The patients’ overall survival rates without and with primary immunodeficiency was 81.1% and 11.1%, respectively. There was a significant difference between these two groups. Cox regression analysis showed that advanced stage and concomitant primary immunodeficiency have been risk factors for prognosis. Conclusion: Intensive treatment approaches have increased overall survival rates in children with non-Hodgkin lymphoma. However, this success rate cannot be achieved in non-Hodgkin lymphoma children with primary immunodeficiency.

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Section: Multivariate Analysismentioning

confidence: 81%

Section: Multivariate Analysismentioning

confidence: 99%

Section: Multivariate Analysismentioning

confidence: 99%

Section: Multivariate Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Hodgkin dışı lenfomalı çocukların klinik özelliklerinin, tedavi yaklaşımlarının ve tedavi sonuçlarının değerlendirilmesi

Kara

Uğraş

Ertan

et al. 2022

Journal of Contemporary Medicine

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Factors associated with unresponsiveness to treatment in patients with non-Hodgkin lymphoma: 10 years of experience from a single center

İpek

2023

Acta Medica Alanya

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Aim: To investigate factors associated with response to treatment in non-Hodgkin lymphoma (NHL) patients receiving chemo(radio)therapy, and secondarily, to identify parameters influencing mortality. Methods: This was a retrospective single center study carried out between January 2013 and December 2022. A total of 245 patients newly diagnosed with NHL who were treated in our department were included. Clinicodemographic features, NHL characteristics, treatments and follow-up data were retrieved from the hospital database and charts. Patients were grouped as responders (RT) and non-responders (NRT) to treatment, as well as deceased (DP) and survivors (SP). Factors associated with response to treatment and mortality were determined by univariate and multivariable analysis. Results: Age was similar in the RT (56.2 ± 14.5) and NRT (59.5 ± 13.7) groups; however, male sex was significantly more frequent in the RT group (58.1% vs. 35.71%; p = 0.042). Multiple logistic regression revealed that female sex, low performance status, frailty, high lymphocyte level, extranodal involvement, mantle cell lymphoma, thrombocytopenia during treatment, and cardiac complications during treatment were independently associated with no response to treatment. With respect to groups based on mortality, the DP group was significantly younger compared to the SP group (50.8 ± 11.7 vs. 57.1 ± 14.6; p = 0.048), while sex distribution was similar (males comprised 54.7% of the DP and 63.6% of SP group). Multiple regression showed that extranodal involvement, thrombosis during treatment, and secondary malignancy were independently associated with mortality. Conclusion: Considering these characteristics when making treatment decisions and throughout the follow-up period may improve survival and reduce mortality in NHL.

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Prognostic Factors in Childhood and Adolescent Non-Hodgkin Lymphoma

Cited by 2 publications

References 108 publications

Hodgkin dışı lenfomalı çocukların klinik özelliklerinin, tedavi yaklaşımlarının ve tedavi sonuçlarının değerlendirilmesi

Hodgkin dışı lenfomalı çocukların klinik özelliklerinin, tedavi yaklaşımlarının ve tedavi sonuçlarının değerlendirilmesi

Factors associated with unresponsiveness to treatment in patients with non-Hodgkin lymphoma: 10 years of experience from a single center

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