Prognostic Factors for Wilms Tumor Recurrence: A Review of the Literature

Groenendijk, Alissa; Spreafico, Filippo; Krijger, Ronald R. de; Drost, Jarno; Brok, Jesper; Perotti, Daniela; Venkatramani, Rajkumar; Godziński, Jan; Rübe, Christian; Geller, James I.; Graf, Norbert; Heuvel‐Eibrink, Marry M. van den; Mavinkurve‐Groothuis, Annelies M. C.

doi:10.3390/cancers13133142

Cited by 35 publications

(38 citation statements)

References 141 publications

(308 reference statements)

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“…The most common form of urologic cancer in children is Wilms tumor (2).Current treatment strategies for Wilms tumor include surgery, chemotherapy and radiotherapy. In high-income countries, 90% of patients with this tumor survive (3). While the OS in high, 20% of patients relapse after first-line therapy and up to 25% of survivors report severe late morbidity of treatment (4,5).And the treatment of children with bilateral, high-risk tumors remains challenging (6).…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Identification of hub genes and construction of prognostic nomogram for patients with Wilms tumors

Lou

Chen²,

Wu³

et al. 2022

Front. Oncol.

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BackgroundIn children, Wilms’ tumors are the most common urological cancer with unsatisfactory prognosis, but few molecular prognostic markers have been discovered for it. With the rapid development of high-throughput quantitative proteomic and transcriptomic approaches, the molecular mechanisms of various cancers have been comprehensively explored. This study aimed to uncover the molecular mechanisms underlying Wilms tumor and build predictive models by use of microarray and RNA-seq data.MethodsGene expression datasets were downloaded from Therapeutically Applicable Research to Generate Effective Treatments (TARGET) and Gene Expression Omnibus (GEO) databases. Bioinformatics methods wereutilized to identified hub genes, and these hub genes were validated by experiment. Nomogram predicting OS was developed using genetic risk score model and clinicopathological variables.ResultsCDC20, BUB1 and CCNB2 were highly expressed in tumor tissues and able to affect cell proliferation and the cell cycle of SK-NEP-1 cells. This may reveal molecular biology features and a new therapeutic target of Wilms tumour.7 genes were selected as prognostic genes after univariate, Lasso, and multivariate Cox regression analyses and had good accuracy, a prognostic nomogram combined gene model with clinical factors was completed with high accuracy.ConclusionsThe current study discovered CDC20,BUB1 and CCNB2 as hub-genes associated with Wilms tumor, providing references to understand the pathogenesis and be considered a novel candidate to target therapy and construct novel nomogram, incorporating both clinical risk factors and gene model, could be appropriately applied in preoperative individualized prediction of malignancy in patients with Wilms tumor.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Identification of hub genes and construction of prognostic nomogram for patients with Wilms tumors

Lou

Chen²,

Wu³

et al. 2022

Front. Oncol.

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“…37 In a recent review of prognostic factors for recurrence in WT, underweight at diagnosis was not discussed as a prognostic factor, likely as less relevant for HICs. 38 Our observation of a lower weight at diagnosis as an independent risk factor for the adverse outcome is unique in the context of WT. Identifying malnutrition and nutritional rehabilitation should be a key intervention for improving the survival of patients with WT in LMICs.…”

Section: Treatment Abandonmentmentioning

confidence: 84%

“…The NWTS-5 and a study from South Africa did not observe a significant influence of undernutrition on overall outcome in WT. 36,38 A meta-analysis evaluating the nutritional status and its influence on outcome in pediatric solid tumors included only one eligible study on WT. 37 In a recent review of prognostic factors for recurrence in WT, underweight at diagnosis was not discussed as a prognostic factor, likely as less relevant for HICs.…”

Section: Treatment Abandonmentmentioning

confidence: 99%

A higher tumor volume and undernutrition at diagnosis adversely affect the survival of children with Wilms tumor: A study of 200 patients

Rahiman

Trehan

Jain

et al. 2022

Pediatric Blood & Cancer

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Background Distinct prognostic factors for Wilms tumor (WT) in low‐ and middle‐income countries need identification. Methods Retrospective study of patients with WT managed by the International Society of Pediatric Oncology (SIOP) approach for over 11 years (2005–2016) at a single center in Chandigarh, India. Results The study included 200 patients (median age: 33.5 months). The tumor stage (SIOP) distribution included stage I (30%), II (36%), III (14%), IV (17%), and V (3%). The histology‐risk groups were low (8%), intermediate (84%), and high risk (9%). At diagnosis, 68 out of 190 (36%) patients were underweight. The median tumor volume at diagnosis was 481 ml (interquartile ratio [IQR]: 306.9, 686.8, n = 146). Following neoadjuvant chemotherapy, it reduced to 110 ml (IQR: 151.2, 222, n = 77). Treatment was abandoned in 20.5% of the patients. Treatment‐related mortality occurred in 13 of 179 (7.2%) patients. Relapse occurred in 26 of 158 (16.5%) patients. The 3‐year overall survival (OS) and event‐free survival (EFS) of patients who completed therapy were 78.3 and 72%, respectively. The stage (p = .013) and histology (p = .023) influenced OS. A lower OS in stage II (75.4%) versus stage III disease (83.7%) suggested understaging. Patients with a higher tumor volume at diagnosis (p = .005; odds ratio [OR]: 0.99; 95% confidence interval [CI]: 0.99–1.00) or a lower weight‐for‐age z‐score (p = .002; OR: 1.68; 95% CI: 1.21–2.33) had an increased risk of death or relapse. Conclusions The 3‐year OS and EFS of children who completed therapy were 78.3 and 72%, respectively. A higher tumor volume and lower weight‐for‐age z‐score at diagnosis were identified as distinct adverse prognostic factors. A likely suboptimal lymph node assessment (intraoperative and histopathology) contributed to the understaging of stage III to II disease and reduced survival.

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“…The curability rate for patients with localized disease is 85%. In stage IV, HR usually reaches 50-60% [16,19]. For 5 years after the end of treatment, regular clinical check-ups are performed at increasing intervals, the most intensive ones shortly after the end of treatment.…”

Section: Prognosismentioning

confidence: 99%

Wilms tumor (nephroblastoma) – clinical and genetic aspects

Janeczko-Czarnecka

Ślężak

Pietras

et al. 2022

Nowotwory. Journal of Oncology

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Nephroblastoma (Wilms tumor -WT) is the most common kidney tumor among the pediatric population, fifth among malignant neoplasms and third among solid tumors. The most common type of WT is sporadic and unilateral. WT occurs either as an isolated, nonsyndromic WT or as syndromic one belonging to the spectrum of a variety of genetic syndromes. Molecular genetic testing should be considered in nonsyndromic WT and include a multigene panel or whole exome sequencing (WES); in syndromic cases single-gene testing, DNA methylation panel and chromosomal microarray. Outcomes of treatment in WT patients remain very good, but there are still subgroups with poor prognosis and increased relapse rates, especially in the blastemic and disseminated anaplasia types. WT survivors have increased risk of chronic kidney disease (CKD). They need further follow-up, not only by oncologists but also by nephrologists, to preserve kidney function or slow down CKD progression.

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Prognostic Factors for Wilms Tumor Recurrence: A Review of the Literature

Cited by 35 publications

References 141 publications

RETRACTED: Identification of hub genes and construction of prognostic nomogram for patients with Wilms tumors

RETRACTED: Identification of hub genes and construction of prognostic nomogram for patients with Wilms tumors

A higher tumor volume and undernutrition at diagnosis adversely affect the survival of children with Wilms tumor: A study of 200 patients

Wilms tumor (nephroblastoma) – clinical and genetic aspects

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