Prognostic Factors for Progression of Visual Field Damage in Patients with Normal-Tension Glaucoma

Nakagami, Takako

doi:10.1007/s10384-006-0416-z

Cited by 3 publications

(6 citation statements)

References 2 publications

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“…The role of IOP reduction of <30% from baseline IOP with topical medications is still controversial in NTG patients. Nakagami et al. (2006) reported that IOP reduction via topical medication was effective for prevention of VF progression in patients with NTG.…”

Section: Discussionmentioning

confidence: 99%

“…However, most previous studies dealing with NTG progression used only VF deterioration as the end‐point (Shigeeda et al. 2002; Nakagami et al. 2006; Seong et al.…”

Section: Discussionmentioning

confidence: 99%

“…Several risk factors have been found to be associated with the prevalence and progression of NTG, such as IOP (CNTGS 1998a,b; Drance et al. 2001; Nakagami et al. 2006; Aoyama et al.…”

Section: Introductionmentioning

confidence: 99%

“…Significant lowering of IOP has been reported to suppress the progression of NTG (CNTGS 1998a,b; Daugeliene et al. 1999; Nakagami et al. 2006; Aoyama et al.…”

Section: Introductionmentioning

confidence: 99%

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Intraocular pressure reduction with topical medications and progression of normal‐tension glaucoma: a 12‐year mean follow‐up study

Kim

Park

et al. 2013

Acta Ophthalmologica

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ABSTRACT.Purpose: To investigate whether the amount of intraocular pressure (IOP) reduction with topical medications is associated with the progression of normal-tension glaucoma (NTG) and to identify risk factors for NTG progression. Methods: The medical records of 121 eyes of 121 NTG patients, who were treated with topical medications for more than 7 years, were reviewed. NTG progression was defined by either structural (optic disc or retinal nerve fibre layer) or functional (visual field) deterioration. Patients were divided into tertile groups according to the percentage IOP reduction from baseline, and the cumulative probability of NTG progression between upper and lower tertile group was compared using Kaplan-Meier survival analysis. Multivariate analysis with Cox's proportional hazard model was performed to identify the hazard ratio (HR) of clinical factors for NTG progression. Results: The average follow-up period was 12.2 years, and 56 of 121 eyes (46.3%) showed the NTG progression. Kaplan-Meier analysis revealed that upper tertile group (percentage IOP reduction >22.1%) showed a greater cumulative probability of non-progression than lower tertile group (percentage IOP reduction < 13.3%; p = 0.012). Multivariate Cox's proportional hazard model indicated that percentage reduction of IOP (HR = 0.964; p = 0.007) and the occurrence of disc haemorrhage (HR = 2.410; p = 0.008) were significantly associated with NTG progression. Conclusions: The amount of IOP reduction using topical medications was related to NTG progression, and lower percentage reduction in IOP was a consistent risk factor for progression.

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Section: Discussionmentioning

confidence: 99%

“…However, most previous studies dealing with NTG progression used only VF deterioration as the end‐point (Shigeeda et al. 2002; Nakagami et al. 2006; Seong et al.…”

Section: Discussionmentioning

confidence: 99%

“…Several risk factors have been found to be associated with the prevalence and progression of NTG, such as IOP (CNTGS 1998a,b; Drance et al. 2001; Nakagami et al. 2006; Aoyama et al.…”

Section: Introductionmentioning

confidence: 99%

“…Significant lowering of IOP has been reported to suppress the progression of NTG (CNTGS 1998a,b; Daugeliene et al. 1999; Nakagami et al. 2006; Aoyama et al.…”

Section: Introductionmentioning

confidence: 99%

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Intraocular pressure reduction with topical medications and progression of normal‐tension glaucoma: a 12‐year mean follow‐up study

Kim

Park

et al. 2013

Acta Ophthalmologica

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“…Previous studies reported that lowering intraocular pressure (IOP) slowed the advancement of visual field damage in glaucoma patients. [1][2][3][4][5][6][7][8][9] However, even if the IOP can be substantially lowered, the reduction of mean and peak IOPs does not always prevent visual field progression. [10][11][12] There are several reports that diurnal IOP variation is a risk factor for glaucoma.…”

Section: Introductionmentioning

confidence: 99%

Long-Term Intraocular Pressure Fluctuation and Visual Field Progression in Glaucoma Patients with Low Intraocular Pressure After Post-Trabeculectomy Phacoemulsification

Hong

Kim

Seong

2007

Journal of Ocular Pharmacology and Therapeutics

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Glaucoma and obstructive sleep apnoea syndrome

Faridi¹,

Park²,

Liebmann³

et al. 2012

Clinical Exper Ophthalmology

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Glaucoma is increasingly recognized as a manifestation of both ocular and systemic risk factors. A number of disorders associated with reduced blood flow and ischaemia, collectively termed vascular risk factors, such as migraine, Raynaud's phenomenon, atrial fibrillation and reduced nocturnal blood pressure, lead to decreased ocular perfusion pressure. During sleep, alterations occur in cardiovascular physiology that are balanced by autoregulation to maintain homeostasis. However, in obstructive sleep apnoea (OSA), the normal physiological balance is upset. A potentially modifiable risk factor, OSA has been increasingly associated with glaucoma independent of intraocular pressure. OSA may alter blood flow to the optic nerve head and, in combination with other predisposing factors, lead to decreased ocular perfusion pressure. This in turn may directly affect the optic nerve or it may indirectly increase its susceptibility to other insults. The purpose of this review is to shed light on the association between OSA and glaucoma.

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Prognostic Factors for Progression of Visual Field Damage in Patients with Normal-Tension Glaucoma

Abstract: Reference1. Spaeth GL, Hwang S, Gomes M. Disc damage as a prognostic and therapeutic consideration in the management of patients with glaucoma. In: Gramer E, Grehn F, editors. Pathogenesis and risk factors of glaucoma.

Cited by 3 publications

References 2 publications

Intraocular pressure reduction with topical medications and progression of normal‐tension glaucoma: a 12‐year mean follow‐up study

Intraocular pressure reduction with topical medications and progression of normal‐tension glaucoma: a 12‐year mean follow‐up study

Long-Term Intraocular Pressure Fluctuation and Visual Field Progression in Glaucoma Patients with Low Intraocular Pressure After Post-Trabeculectomy Phacoemulsification

Glaucoma and obstructive sleep apnoea syndrome

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