Prognostic factors for post-recurrence survival among patients with locally advanced cervical cancer who underwent definitive concurrent chemoradiation

Thongkhao, Pitchaya; Janmunee, Narumon; Tangkananan, Aimwarin

doi:10.5603/rpor.a2022.0078

Cited by 2 publications

(2 citation statements)

References 24 publications

(55 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to the Pitchaya Thongkhao’s 2022 report, which analyzed 1658 patients with locally advanced cervical cancer undergoing concurrent chemoradiation therapy with brachytherapy based on point A, it was found that roughly 75% of recurrence cases occurred within two years after completing treatment, and an approximate locoregional recurrence rate of 18% [ 21 ]. With a median follow-up time of 19 months, we observed 3 cases of locoregional recurrence (accounting for 4.2%) and the locoregional control rate in our study was 95.8%.…”

Section: Discussionmentioning

confidence: 99%

Outcome and toxicity of chemoradiation using volumetric modulated arc therapy followed by 3D image-guided brachytherapy for cervical cancer: Vietnam National Cancer Hospital experience

Van Anh,

Thang,

Dung

et al. 2024

Rep Pract Oncol Radiother.

View full text Add to dashboard Cite

Background Volumetric modulated arc therapy (VMAT) and 3D image-guided brachytherapy (3D-IGBT) have recently been introduced in Vietnam for the treatment of locally advanced cervical cancer. This study aims to assess the outcomes and toxicities of chemoradiation using VMAT followed by 3D-IGBT in Vietnamese cervical cancer patients. Materials and methods A prospective interventional study on 72 patients with 2018 International Federation of Gynecology and Obstetrics (FIGO) stage IB3–IIIC2 disease who underwent concurrent chemoradiation using VMAT, followed by 3D-IGBT according to EMBRACE-II protocol. Primary endpoints were locoregional control; secondary endpoints were systemic control and toxicity. Results Median body volume received 43 Gy was 1589.1 cm 3 (range 1214.8–2574.8). Median high-risk clinical target volume (CTV-HR) was 18.8 cm 3 (range 8.6–61.2) with a median dose to 90% (D90) of CTV-HR of 90.6 Gy (range 86.8–99.6). Mean doses to 2cc (D2cc) of bladder, rectum, and sigmoid were 75.8, 55.2, and 62.1 Gy, respectively. At median 19-month follow-up (range 12–25), locoregional control and systemic control were 95.8% and 81.9%, respectively. Systemic control was the lowest in N2 disease (54.5%). Grade ≥ 3 acute toxicities were less than 10%, except neutropenia (31.9%). Extended-field radiation increased significantly nausea, fatigue, and thrombocytopenia. No grade ≥ 3 proctitis or cystitis; 8.3% had grade 3 vaginal stenosis. Conclusions VMAT-based chemoradiation therapy followed by 3D-IGBT achieved high locoregional control with manageable toxicities in locally advanced cervical cancer. Systemic control correlated with disease stage.

show abstract

Section: Discussionmentioning

confidence: 99%

Outcome and toxicity of chemoradiation using volumetric modulated arc therapy followed by 3D image-guided brachytherapy for cervical cancer: Vietnam National Cancer Hospital experience

Van Anh,

Thang,

Dung

et al. 2024

Rep Pract Oncol Radiother.

View full text Add to dashboard Cite

show abstract

“…There are studies reporting that pretreatment hemoglobin level, leukocyte, and platelet counts are associated with the prognosis of locally advanced cervical cancer patients undergoing CCRT. 48 , 49 After using the CCRT-nomogram to predict the probability that individual patient is suitable to receive CCRT, the prognostic nomogram could effectively predict the prognosis of newly diagnosed mCC patients. However, the administration of CCRT in this study was affected by human subjective factors, and the model should be validated with larger samples and in prospective study.…”

Section: Discussionmentioning

confidence: 99%

Dynamic Nomogram Based on the Metastatic Number and Sites and Therapy Strategies Predicting the Prognosis of Patients with Metastatic Cervical Cancer

Tan

et al. 2022

IJWH

View full text Add to dashboard Cite

Background Individual survival prediction is of vital importance to optimize the individualized treatment of metastatic cervical cancer (mCC) patients. The goal of this study was to identify the potential risk factors for the survival of mCC patients and construct a nomogram for their prognosis. Methods Medical records of patients with newly diagnosed mCC at the First Affiliated Hospital of Xi’an Jiaotong University were reviewed retrospectively. Risk factors were identified using Cox proportional hazards analysis and Kaplan–Meier curves. Random forest was used to identify factors associated with therapy strategy. Nomogram and dynamic nomogram were established using ‘rms’ and “DynNom” R package. Results A total of 98 patients with mCC were finally identified. In Cox analyses, multiple metastases and concurrent chemoradiotherapy (CCRT) were identified as independent predictors for overall survival (OS). We further explored the prognostic value of metastatic number and sites and therapy strategies for mCC patients by Kaplan–Meier curves. A dynamic nomogram including metastases number and sites (multiple metastases, liver and lymph node (LN) above diaphragm metastases) and chemoradiotherapy strategies (CCRT, postradiotherapy chemotherapy, and radiotherapy to metastatic sites) was constructed for predicting the prognosis of mCC patients. For newly diagnosed patients, we strongly recommended the combination of chemotherapy and definitive pelvic radiotherapy and, if possible, radiation to metastatic site, but CCRT should be implemented with caution. We constructed a dynamic nomogram indicating that patients with younger age, shorter symptom duration, and better laboratory test results are suitable for CCRT. Conclusion Survival analyses showed that the metastatic number and sites and therapy strategies are associated with the prognosis of mCC patients. The CCRT and prognostic nomograms may help clinicians to make better clinical decisions and effectively predict the prognosis for newly diagnosed mCC patients.

show abstract

Prognostic factors for post-recurrence survival among patients with locally advanced cervical cancer who underwent definitive concurrent chemoradiation

Abstract: This article has been peer reviewed and published immediately upon acceptance.It is an open access article, which means that it can be downloaded, printed, and distributed freely, provided the work is properly cited.

Cited by 2 publications

References 24 publications

Outcome and toxicity of chemoradiation using volumetric modulated arc therapy followed by 3D image-guided brachytherapy for cervical cancer: Vietnam National Cancer Hospital experience

Outcome and toxicity of chemoradiation using volumetric modulated arc therapy followed by 3D image-guided brachytherapy for cervical cancer: Vietnam National Cancer Hospital experience

Dynamic Nomogram Based on the Metastatic Number and Sites and Therapy Strategies Predicting the Prognosis of Patients with Metastatic Cervical Cancer

Contact Info

Product

Resources

About