Prognostic factors for nosocomial bacteraemia outcome: a prospective study in a Greek teaching hospital

Arvanitidou, Malamatenia; Katikaridou, E.; Douboyas, J.; Tsakris, Athanassios

doi:10.1016/j.jhin.2005.03.006

Cited by 15 publications

(15 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nosocomial infection, nosocomial pneumonia, older age, high APACHE II score, mechanical ventilation, enteral nutrition, tracheostomy and use of steroids or chemotherapy were found to be the most important risk factors for mortality in ICU [24][25][26] similar to our study and those of others [27][28][29][30] .…”

Section: Discussionsupporting

confidence: 90%

Risk Factors for Mortality of Nosocomial Bacteraemia in Intensive Care Units

Çağatay

Özcan²,

Gulec

et al. 2007

Med Princ Pract

View full text Add to dashboard Cite

Objective: The aim of this study was to follow critically ill patients prospectively in intensive care units (ICUs) to determine risk factors for mortality and outcome associated with nosocomial bacteraemia (NB). Subjects and Methods: A case-control study of 176 patients was conducted to identify the risk factors for mortality of NB in ICU patients. The study was performed in emergency, surgical and general surgical ICUs with 23 beds during a 15-month period. A total of 1,450 patients were admitted to the ICUs during the study period. The USA Center for Disease Control and Prevention definitions were used to diagnose nosocomial infections. Nosocomial bacteraemia was defined as the isolation of one or more organisms from blood cultures taken at least 48 h after admission, which were not related to a problem present on admission. An assessment of whether the isolated organisms represented true bacteraemia rather than contamination was made by clinical or laboratory evidence of infection. Results: A total of 214 bacteraemia episodes were found in the 176 patients (64 female, 112 male; 51.3 ± 21.3 years old), 90 of whom died and 86 survived. The bacteraemia rate was 12.1%. The most common etiological agents of bacteraemia were Klebsiella pneumoniae: 46 (21.5%), methicillin-resistant Staphylococcus aureus: 46 (21.5%), Pseudomonas aeruginosa: 32 (14.9%), and Escherichia coli: 20 (9.3%). Multivariate analysis showed that the requirement of mechanical ventilation for more than 7 days (p < 0.001), total parenteral nutrition (p = 0.034), inotropic drug (p < 0.001), and increased creatinine level (p = 0.034) were independent risk factors for mortality of NB in ICUs. Conclusions: Nosocomial infections caused by Gram-negative bacteria continue to be one of the major sources of morbidity and mortality.

show abstract

Section: Discussionsupporting

confidence: 90%

Risk Factors for Mortality of Nosocomial Bacteraemia in Intensive Care Units

Çağatay

Özcan²,

Gulec

et al. 2007

Med Princ Pract

View full text Add to dashboard Cite

show abstract

“…Although the importance of smoking cessation has been emphasized in the therapeutic plan of patients with serious infections [32], there are only a few other studies of the effect of smoking on case fatality in bacteraemia. Arvanitidou and colleagues studied epidemiological and clinical features as potential prognostic factors for outcomes of hospital-acquired bacteraemia in a tertiary care teaching hospital in Greece [14]. They found no differences between non-survivors and survivors in sex, age or smoking habit [14].…”

Section: Discussionmentioning

confidence: 99%

“…Arvanitidou and colleagues studied epidemiological and clinical features as potential prognostic factors for outcomes of hospital-acquired bacteraemia in a tertiary care teaching hospital in Greece [14]. They found no differences between non-survivors and survivors in sex, age or smoking habit [14]. Pittet and associates concluded that smoking or alcohol abuse did not reach statistical significance as independent risk factors for case fatality in septicaemia.…”

Section: Discussionmentioning

confidence: 99%

“…However, some studies have found no statistically significant association between alcoholism and case fatality [2,3,13]. A recent study of epidemiological and clinical features as potential prognostic factors for outcomes of hospital-acquired bacteraemia found no differences between non-survivors and survivors in sex, age or smoking habit [14]. In bacteraemias other than pneumococcal, the effect of smoking and alcoholism on case fatality has not been widely studied.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Obesity and smoking are factors associated with poor prognosis in patients with bacteraemia

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Studies on the impact of smoking on bacteraemia outcome are limited, and those conducted so far have yielded inconsistent results [12,13,[41][42][43][44]. Current smoking was a risk factor for case fatality in a population-based cohort study in invasive pneumococcal disease [13].…”

Section: Bacteraemia and Sepsismentioning

confidence: 99%