Prognostic Factors for Node-Negative Advanced Gastric Cancer after Curative Gastrectomy

Lee, Eun Woo; Lee, Woo Yong; Koo, Hyeon‐Kyoung

doi:10.5230/jgc.2016.16.3.161

Cited by 11 publications

(9 citation statements)

References 19 publications

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“…The present study also revealed that LBVI+ status was related to poor prognosis in this setting, although it was not an independent prognostic factor. Previous studies revealed that LBVI+ status is associated with poor prognosis after radical surgery for gastric cancer, and is an independent predictor of poor prognosis in patients with negative lymph nodes[18-20].…”

Section: Discussionmentioning

confidence: 99%

Retrospective evaluation of lymphatic and blood vessel invasion and Borrmann types in advanced proximal gastric cancer

Gao¹,

Cao²,

Ding³

et al. 2019

WJGO

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BACKGROUND The Borrmann classification system is used to describe the macroscopic appearance of advanced gastric cancer, and Borrmann type IV disease is independently associated with a poor prognosis. AIM To evaluate the prognostic significance of lymphatic and/or blood vessel invasion (LBVI) combined with the Borrmann type in advanced proximal gastric cancer (APGC). METHODS The clinicopathological and survival data of 440 patients with APGC who underwent curative surgery between 2005 and 2012 were retrospectively analyzed. RESULTS In these 440 patients, LBVI+ status was associated with Borrmann type IV, low histological grade, large tumor size, and advanced pT and pN status. The 5-year survival rate of LBVI+ patients was significantly lower than that of LBVI– patients, although LBVI was not an independent prognostic factor in the multivariate analysis. No significant difference in the prognosis of patients with Borrmann type III/LBVI+ disease and patients with Borrmann type IV disease was observed. Therefore, we proposed a revised Borrmann type IV (r-Bor IV) as Borrmann type III plus LBVI+, and found that r-Bor IV was associated with poor prognosis in patients with APGC, which outweighed the prognostic significance of pT status. CONCLUSION LBVI is related to the prognosis of APGC, but is not an independent prognostic factor. LBVI status can be used to differentiate Borrmann types III and IV, and the same approach can be used to treat r-Bor IV and Borrmann type IV.

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Section: Discussionmentioning

confidence: 99%

Retrospective evaluation of lymphatic and blood vessel invasion and Borrmann types in advanced proximal gastric cancer

Gao¹,

Cao²,

Ding³

et al. 2019

WJGO

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“…When the LNR was defined as the number of metastatic lymph nodes divided by the retrieved lymph nodes, it was a stronger predictive risk factor for recurrence than the 7 th and 8 th AJCC staging system. Several previous studies of the predictive value of LNR have reported that its use was inconclusive (9,(21)(22)(23). In contrast, other studies showed that LNR was as an independent prognostic factor in gastric cancer (16,17,24,25).…”

Section: Discussionmentioning

confidence: 98%

“…More than half of advanced gastric cancer cases have lymph node metastasis, and lymph node involvement is the most important indicator for survival following a curative resection (R0). Improved survival was observed in node-negative compared to node-positive gastric cancer cases (8,9).…”

Section: Introductionmentioning

confidence: 90%

The predictive factors of gastric cancer recurrence after the completion of adjuvant chemotherapy in advanced gastric cancer

et al. 2019

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Objective: the administration of adjuvant chemotherapy after a curative resection is accepted as the standard treatment to improve the prognosis of advanced gastric cancer. Nevertheless, the prognosis of recurrence-related gastric cancer is still not clinically satisfactory. We aimed to assess the therapeutic yield of a radical gastrectomy with D2 lymphadenectomy (R0 resection) and the completion of adjuvant chemotherapy. The predictive risk factors for recurrence were also assessed. Methods: a retrospective cohort study was designed with patients diagnosed with advanced gastric cancer. Patients with an R0 resection who had completed adjuvant chemotherapy were included in the study. Results: data from 130 patients who had undergone an R0 resection and had completed six cycles of adjuvant chemotherapy were analyzed. The chemotherapy compliance rate was 63.11% and the overall recurrence rate was 36.9%. The lymph node ratio (LNR), which was defined as the number of metastatic lymph nodes divided by the retrieved lymph nodes, was a significant risk factor in the lymph node-positive group (p < 0.01). This parameter had a relatively high sensitivity to predict recurrence compared with the 7 th and 8 th edition of the AJCC staging system, with an area under the curve of 0.735 (95% confidence interval: 0.639-0.832). Baseline CA19-9 level was a risk factor in the lymph node-negative group (p = 0.01). Conclusions: LNR and baseline CA19-9 levels, as simple markers, had strong predictive values for the recurrence of advanced gastric cancer. With regard to recurrence, more potent adjuvant therapy should be considered in high-risk patients.

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“…Gastric cancer is the fourth most prevalent cancer in the world 1 , and is the thirdleading cause of cancer-related death worldwide. 2 Although there is a downgrade in incidence and mortality of gastric cancer in Europe, Portugal still remain as one of the most affected European countries, probably due to high prevalence of Helicobacter pylori infection.…”

Section: Introductionmentioning

confidence: 99%

Prognostic factors in node-negative advanced gastric cancer

Martins

Santos‐Sousa

Nogueiro

et al. 2019

European Journal of Surgical Oncology

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abaixo assinado, nº mecanográfico 201303096, estudante do 6º ano do Ciclo de Estudos Integrado em Medicina, na Faculdade de Medicina da Universidade do Porto, declaro ter atuado com absoluta integridade na elaboração deste projeto de opção.Neste sentido, confirmo que NÃO incorri em plágio (ato pelo qual um indivíduo, mesmo por omissão, assume a autoria de um determinado trabalho intelectual, ou partes dele). Mais declaro que todas as frases que retirei de trabalhos anteriores pertencentes a outros autores, foram referenciadas, ou redigidas com novas palavras, tendo colocado, neste caso, a citação da fonte bibliográfica.

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Prognostic Factors for Node-Negative Advanced Gastric Cancer after Curative Gastrectomy

Cited by 11 publications

References 19 publications

Retrospective evaluation of lymphatic and blood vessel invasion and Borrmann types in advanced proximal gastric cancer

Retrospective evaluation of lymphatic and blood vessel invasion and Borrmann types in advanced proximal gastric cancer

The predictive factors of gastric cancer recurrence after the completion of adjuvant chemotherapy in advanced gastric cancer

Prognostic factors in node-negative advanced gastric cancer

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