Prognostic factors for myasthenia gravis treated by thymectomy: review of 61 cases

Nieto, I.; Robledo, Juan Pedro Pérez; Pajuelo, M. Casillas; Montes, J. A. Rodríguez; Girón, Joaquin; Alonso, J; Sancho, Luís

doi:10.1016/s0003-4975(99)00310-0

Cited by 81 publications

(53 citation statements)

References 9 publications

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“…The atypical gender preponderance may have affected the clinical outcomes in this study, as a previous study found that female patients responded better than males (5). In contrast, another study found that gender did not affect clinical outcomes (8).…”

Section: Resultsmentioning

confidence: 69%

“…Ozdemir et al (18) found a 7-fold increased risk of clinical worsening in patients with stage IIb and III disease. Nieto et al (8) found that patients with stage I and III disease had a better outcome than those with other stages. Similar to those findings, Venuta et al (19) found that patients with a lower Osserman stage had favourable outcomes.…”

Section: Resultsmentioning

confidence: 99%

“…Nieto et al (8) reported that 46% of MG patients who underwent a thymectomy achieved complete remission in a 5-year follow-up study. Maggi et al (9) reported a higher remission rate in a 5-10-year follow-up study of MG patients following a thymectomy.…”

Section: Resultsmentioning

confidence: 99%

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Thymectomy for Myasthenia Gravis: A 10-year Review of Cases at the Hospital Universiti Sains Malaysia

Muhammed

Chen

Hitam

et al. 2016

MJMS

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Background: A thymectomy is considered effective for patients with myasthenia gravis (MG).Although a few studies have described the role of a thymectomy in the treatment of MG in Asians countries, there are no published data on the application of this surgical approach for MG in Malaysia. We aimed to describe the clinical outcomes of MG patients who underwent a thymectomy and the factors affecting these outcomes.Methods: This was a retrospective study involving 16 patients with MG who underwent a thymectomy at the Hospital Universiti Sains Malaysia (HUSM) from January 2002 until December 2012, with a follow-up period ranging from 3-120 months.Results: The study consisted of 16 patients aged 22-78 years, 10 of whom were males. The overall remission/improvement rate was 87.5%, and the rate of clinical outcomes classified as unchanged/ worsened was 12.5%. Thymomamatous or non-thymomamatous MG, histology features, Osserman stage and the duration of follow-up were not significant prognostic factors. Post-operative mortality was 6.2% (1 of 16 patients died of septic shock).Conclusion: A thymectomy seems to be an effective treatment for MG, with low surgical morbidity. Patients with a lower Osserman stage and those with/without thymomas had favourable outcomes.

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Section: Resultsmentioning

confidence: 69%

Section: Resultsmentioning

confidence: 99%

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Thymectomy for Myasthenia Gravis: A 10-year Review of Cases at the Hospital Universiti Sains Malaysia

Muhammed

Chen

Hitam

et al. 2016

MJMS

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“…IGF-1 is involved in vascular tone regulation, probably via its effect on NO bioavailability, reduction in intracellular calcium levels and myosin light chain sensitivity in vascular smooth mucle cells and ability to regulate, both directly and indirectly, endothelin-1 gene expression and signalling 25 . In addition, the adult brain requires IGF-1 for reactive vessel remodeling, a process important for supporting tissue with an adequate amount of oxygen and nutrients 10 .…”

Section: ) the Protective Role Of Igf-1 In The Cardiovascular Systemmentioning

confidence: 99%

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2015

Gyrus

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“…The rate of remission in the presence of thymic hyperplasia was 42% compared to 18% in patients with thymoma. Thymectomy is not recommended in patients with anti-MuSK antibodies, because of the typical thymus pathology, which is very different than in the more common type of MG. 15,24,25 During the past decades, significant progress has been made in our understanding of myasthenia gravis. Nowadays, it is one of the best understood autoimmune disorders.…”

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confidence: 99%

Myasthenia gravis - a review

Ivičić¹

2015

Gyrus

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Summary: Myasthenia gravis is the best studied example of a neuromuscular junction disease. The most important form is the autoimmune form of the disease, which is caused by the binding of autoantibodies to proteins involved in neuromuscular transmission -the nicotinic ACh receptor or (less commonly) the muscle-specific tyrosine kinase. These interactions reduce the number of functional receptors and alter the neuromuscular junction morphology. Prevalence rates have increased to 200-400 cases per million in the last decades. Acquired myasthenia gravis is characterized by skeletal muscle weakness that worsens with exertion, and improves with rest. The involvement of extrinsic ocular muscle presents as the initial symptom in about two-thirds of patients, usually progressing and affecting other bulbar muscles and limb muscles, which is called generalized myasthenia gravis. During the past decades, remarkable progress has been made in understanding of myasthenia gravis, and as nowadays this disease is highly treatable. Early recognition and diagnosis is crucial.

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Prognostic factors for myasthenia gravis treated by thymectomy: review of 61 cases

Cited by 81 publications

References 9 publications

Thymectomy for Myasthenia Gravis: A 10-year Review of Cases at the Hospital Universiti Sains Malaysia

Thymectomy for Myasthenia Gravis: A 10-year Review of Cases at the Hospital Universiti Sains Malaysia

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Myasthenia gravis - a review

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