Prognostic Factors for Metastasis in Squamous Cell Carcinoma of the Skin

Abstract

Patients with tumors that exhibit certain clinical and histologic features are more likely to metastasize and need close follow-up to detect recurrence and metastasis early, allowing for appropriate life-saving intervention. Sentinel lymph node biopsy should be considered in patients with high-risk SCC.

Sentinel node biopsy for high-risk cutaneous squamous cell carcinoma

“…Overall, 6 patients were SN-metastasis positive (23.1%), of which the primary lesion was on the external genitalia in 3 cases (No. 3,8,14), on an upper extremity in 2 cases (No. 5, 25), and on a lower extremity in 1 case (No.…”

Utility of sentinel node biopsy in patients with high-risk cutaneous squamous cell carcinoma

“…This may be due to lack of information about the differentiation in many of the studies. According to Cherpelis et al 28 ulceration may not be an independent risk-factor for metastasis but we chose to include it as it is still the common view.…”

Skin Cancer Knowledge and Preventive Behaviors among Patients with a Recent History of Cutaneous Squamous Cell Carcinoma

“…Considering that cutaneous SCC patients have an increased risk of new primary skin cancers, including melanoma, and that 70–80% of SCC recurrences take place within 2 years after treatment (and 95% within 5 years), a follow-up is generally recommended during this period of time [1,9,10,11,12]. Recommendations for higher-risk patients include total skin examinations performed by health professionals, patient education about skin self-examination (SSE) and sun protection [1, 12, 13].…”