Prognostic Factors for Groin Node Metastasis in Squamous Cell Carcinoma of the Vulva (A Gynecologic Oncology Group Study)

Homesley, Howard D.; Bundy, Brian N.; Sedlis, Alexander; Yordan, Edgardo; Berek, Jonathan S.; Jahshan, Antoine E.; Mortel, Rodrigue

doi:10.1006/gyno.1993.1127

Cited by 240 publications

(87 citation statements)

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“…Homesley ve ark.larının çalışmasında LN metastazı negatif, 1-2 pozitif, 3-4 pozitif ve 5-6 pozitif grupta 5 yıllık sağkalım oranları sırasıyla %91, %75, %36 ve %24 olarak bildirilmiştir (7). Benzer olarak Woelber ve ark.larının çalışmasında 1, 2 ve >2 adet metastatik LN saptanan hastalarda hastalıksız sağkalım oranları sırasıyla %60, %43 ve %29 olarak bulunmuştur (13).…”

Section: Discussionunclassified

Vulva Skuamöz Hücreli̇ Karsi̇nomunda Radyoterapi̇ Sonrasi Rekürrens Özelli̇kleri̇ / Recurrence Paterns of Vulvar Squamous Cell Carcinoma Followed by Radiotherapy

Metcalfe

Etiz

Özen

et al. 2016

Osmangazi̇ Journal of Medicine

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Section: Discussionunclassified

Vulva Skuamöz Hücreli̇ Karsi̇nomunda Radyoterapi̇ Sonrasi Rekürrens Özelli̇kleri̇ / Recurrence Paterns of Vulvar Squamous Cell Carcinoma Followed by Radiotherapy

Metcalfe

Etiz

Özen

et al. 2016

Osmangazi̇ Journal of Medicine

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“…13 In addition, FIGO stage does not fully reflect some important prognostic factors. These include the number of positive inguinal-femoral lymph nodes 14 , omission of lymphadenectomy, and margin status. 10 Therefore, a nomogram, which incorporates more clinical and pathologic factors than the staging system, can allow the clinician to achieve a better estimation of the prognosis of an individual patient.…”

Section: Discussionmentioning

confidence: 99%

Validation of a nomogram for predicting outcome of vulvar cancer patients, primarily treated by surgery, in Korean population: multicenter retrospective study through Korean Gynecologic Oncology Group (KGOG-1010)

Kim

Lee

et al. 2008

J Gynecol Oncol

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Objective: Regarding vulvar cancer, a nomogram has been suggested for the prediction of relapse-free survival (RFS). While the nomogram has been developed and validated in a Western study, there was no validation in Korean population. Thus, we have undertaken the study to assess the applicability of nomogram for predicting RFS in Korean patients with vulvar cancer. Methods: A total of 204 cases newly diagnosed as vulvar cancer between 1982 and 2006 were identified. Among them 70 cases were not eligible due to inappropriate cell type (40 cases) and radiation as primary therapy (30 cases). Fortyfour cases were not evaluable due to inadequate data and persistent disease. Finally a total of 90 patients primarily treated by surgery were included for analysis. Variables including age and the characteristics of primary tumor, nodal status, and surgical margin were collected for predicting RFS based on nomogram, which was compared with actual RFS. A calibration plot was drawn showing the actual versus predicted probability for 6 groups of patients segregated according to their predicted probabilities. In addition, discrimination of the nomogram was quantified with the concordance index. Results: Patients' mean age was 58 years and mean follow-up period was 47.9 months. Observed 2y-and 5y-RFS rates were 81% and 68%, respectively, corresponding to 79% and 72% in the original cohort. The trend line in calibration plot showed comparable concordance with an ideal line, having a slope of 1.04 for 2y-RFS (R 2 =.35) and 0.98 for 5y-RFS (R 2 =.80), respectively. The concordance index was 0.79 in the KGOG data set, which was improved to 0.82 with the data set limited to squamous cell carcinoma. Conclusion:The nomogram provides the predictive capacity for relapse-free survival in Korean patients with vulvar cancer.

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“…The overall survival probability at 5 years was 22% for patients with bilateral lymph node involvement (8). In a prospective GOG study the involvement of inguinal lymph nodes was rated as clinically negative in 81% of the cases.…”

Section: P-value -------------------------------------------------mentioning

confidence: 99%

“…Of the clinically negative lymph nodes, 24% were affected histopathological by tumor. A false-positive lymph node diagnosis was obtained in 20% of the cases (8).…”

Section: Introductionmentioning

confidence: 99%

Prophylactic inguinal-femoral irradiation as an alternative to primary lymphadenectomy in treatment of vulvar carcinoma

Hallak

Ladi²,

Sorbe

2007

Int J Oncol

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Abstract. In a complete geographic series of 294 cases of primary vulvar carcinomas prophylactic inguinal-femoral irradiation was used as a standard postoperative therapy. Inguinal lymph node dissection was performed in only 27 cases (9%) and was not part of the standard surgery. The histology was squamous cell carcinoma in 269 cases (92%). The primary surgery was total vulvectomy, partial vulvectomy, or local resection of the tumor. The main type of radiotherapy was adjuvant inguinal irradiation. Two separate, symmetrical and rectangular inguinal fields were irradiated with combined photon and electron beams. In the complete series 127 recurrences (43%) were recorded. Local (24%) and regional recurrences (19%) were most frequent. Type of surgery was not associated with the risk of tumor recurrence. The 5-year overall survival rate was 53% and the relapse-free survival (RFS) rate was 55%. Tumor grade was significantly (P=0.007) associated with the RFS. The inguinal RFS rate was 75% both for patients treated with adjuvant inguinal irradiation without lymphadenectomy and patients treated with primary lymphadenectomy ± inguinal irradiation. Postoperative complications were recorded in 22%. Postoperative complications occurred most frequently in the subgroup undergoing inguinal lymphadenectomy. Chronic lymph edemas were the most serious late tissue reactions.

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Prognostic Factors for Groin Node Metastasis in Squamous Cell Carcinoma of the Vulva (A Gynecologic Oncology Group Study)

Cited by 240 publications

References 0 publications

Vulva Skuamöz Hücreli̇ Karsi̇nomunda Radyoterapi̇ Sonrasi Rekürrens Özelli̇kleri̇ / Recurrence Paterns of Vulvar Squamous Cell Carcinoma Followed by Radiotherapy

Vulva Skuamöz Hücreli̇ Karsi̇nomunda Radyoterapi̇ Sonrasi Rekürrens Özelli̇kleri̇ / Recurrence Paterns of Vulvar Squamous Cell Carcinoma Followed by Radiotherapy

Validation of a nomogram for predicting outcome of vulvar cancer patients, primarily treated by surgery, in Korean population: multicenter retrospective study through Korean Gynecologic Oncology Group (KGOG-1010)

Prophylactic inguinal-femoral irradiation as an alternative to primary lymphadenectomy in treatment of vulvar carcinoma

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