Prognostic factors for cats with squamous cell carcinoma of the nasal planum following high-dose rate brachytherapy

Lino, Mafalda; Lanoré, D.; Lajoinie, Mathilde; Jimenez, Ana; Crouzet, Franck; Queiroga, Felisbina L.

doi:10.1177/1098612x18822409

Cited by 6 publications

(5 citation statements)

References 58 publications

(244 reference statements)

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“…The most common age of presentation for squamous cell carcinoma in this study was 7-10 years (mature cats), deviating slightly from previous reports describing an older age of occurrence (11-14 years). 7,17,18,23 The frequency of squamous cell carcinoma in older cats was half of that observed for mature cats in this study. Since this type of neoplasm is strongly related to sunlight exposure, 17,18 we can speculate than the lifestyle and the outdoor habits in the studied cat population could be a reason for the high occurrence and early presentation of this type of tumor, contrary to the largely indoor cat populations found in other countries.…”

Section: Discussionmentioning

confidence: 54%

“…7,17,18,23 The frequency of squamous cell carcinoma in older cats was half of that observed for mature cats in this study. Since this type of neoplasm is strongly related to sunlight exposure, 17,18 we can speculate than the lifestyle and the outdoor habits in the studied cat population could be a reason for the high occurrence and early presentation of this type of tumor, contrary to the largely indoor cat populations found in other countries. Indeed, the low prevalence of squamous cell carcinoma reported in the Graf et al study 23 could be associated with differences in temperature and sunlight exposure between Mexico and Switzerland.…”

Section: Discussionmentioning

confidence: 54%

“…Squamous cell carcinoma was the most common neoplasm in cats from this work, making up 17% of cases (n=117), a result that is comparable to that found in other studies. 14,[17][18][19] Manuali et al found this histotype as the most common malignancy among skin (28.8%), oral cavity and tongue tumors (46%). 15 Other studies in cats focusing on cutaneous neoplasms in the head, neck and oral mucosa also found a predominant presentation of this histotype.…”

Section: Discussionmentioning

confidence: 99%

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Tumor prevalence in cats: experience from a reference diagnostic center in Mexico City (2006-2018)

et al. 2020

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Records of referred cat cases received for diagnosis in the Department of Pathology of the National Autonomous University of Mexico, School of Veterinary Medicine and Animal Husbandry between 2006 and 2018, were reviewed to examine frequency of occurrence of neoplasms and associated demographic factors. To this end, the records of biopsies, necropsies and clinical information were analyzed to obtain data on animal sex and age, as well as neoplasm histotype, tissue of origin, and malignant/benign biological behavior. A total of 685 neoplasm cases were diagnosed during the study period, which represented 37.7% of all referred histopathological domestic cat cases. Epithelial neoplasms were the most prevalent (56% of cases), followed by mesenchymal tumors (27%), and hematopoietic and lymphoreticular neoplasms (17%). The most common tumor type was carcinoma (31%), followed by sarcoma (14%), adenocarcinoma (13%), lymphoma (13%), and adenoma (6%). Squamous cell carcinoma was the most frequent form of carcinoma (117 cases), followed by lymphoma (88 cases), and spindle cell sarcoma (56 cases). Approximately 85% of all cases corresponded to malignant neoplasms. A relationship between sex and histogenesis was observed, but there was no gender association with malignant behavior. Also, hematopoietic/lymphoreticular tumors occurred more frequently at an early age, than other types of neoplasms. To the extent of our knowledge, this is the first epidemiological report indicating the most common neoplasms in a Mexican domestic cat population.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

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Tumor prevalence in cats: experience from a reference diagnostic center in Mexico City (2006-2018)

et al. 2020

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“…Larger studies could also assist in identifying potential prognostic indicators (e.g., tumor clinical stage, sex, previous treatment, etc. ), 24,25,31 fine-tune PDT protocol, investigate longer follow-up times, and optimize peri-operative care to improve patient comfort and clinical outcomes. Another study limitation is the lack of complete clinical staging, although metastatic disease was considered unlikely due to the relatively early stage of disease, physical examination findings (both cats) and cytological findings of the regional lymph node (one cat).…”

Section: Discussionmentioning

confidence: 99%

Marginal resection and infracyanine green‐mediated photodynamic therapy in the management of feline eyelid squamous cell carcinoma: Two cases

Sebbag,

Pe'er

2024

Veterinary Ophthalmology

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ObjectiveDescribe the presenting features, surgical procedure, and clinical outcomes of two cats managed with marginal resection and photodynamic therapy (PDT) for eyelid squamous cell carcinoma (SCC).Animals StudiedA 12‐year‐old female spayed domestic shorthair cat (case 1) and a 10‐year‐old female spayed domestic shorthair cat (case 2).ProceduresFollowing marginal resection of the eyelid neoplasm, hemostasis was achieved using a handheld cautery unit then 1 mL of infracyanine green was injected into the surgical wound bed. Photodynamic therapy was performed using an 810 nm diode laser in two consecutive steps: (i) six cycles at 500 mW for 30 s per cycle, using a rapid movement; then (ii) one (case 1) or two cycles (case 2) of 30 s at 2000 mW, using a slow deliberate movement to effect (charred surface).ResultsHistopathology was consistent with SCC resected with incomplete margins in both cats. Follow‐up duration was 416 and 161 days in case 1 and case 2, respectively. Consecutive exams and photo‐documentation (in clinic or by owners) showed appropriate healing of the lower eyelid, with a smooth lid margin, and no evidence of tumor regrowth or ocular irritation. Subtle trichiasis was noted in case 1 on day 185, but not at the last follow‐up.Conclusions and Clinical RelevanceMarginal resection followed by PDT may be a valid alternative to complete surgical resection of periocular SCC in cats. The procedure was easy to perform, post‐operative recovery was uncomplicated, and neither cat developed recurrent disease during the follow‐up period.

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“…14 High-dose brachytherapy with a total dose of 30 Gy delivered over 4–5 fractions for nasal plane SCCs has also been assessed, yielding a median progression-free survival and MST of 316 and 835 days, respectively. 15 Flash RT, which is a novel irradiation modality where large doses of radiation are delivered in single fractions, was assessed as part of a dose-escalation study in six cats with nasal planum SCCs. 16 Patients in this study had stage T2–T3 disease, and received 25–41 Gy in a single fraction of treatment.…”

Section: Introductionmentioning

confidence: 99%

Pilot study evaluating stereotactic body radiation therapy for feline facial squamous cell carcinomas

Swan¹,

Morrow²,

Lurie³

2021

Journal of Feline Medicine and Surgery

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Objectives The use of stereotactic body radiation therapy (SBRT) has not been assessed in advanced-stage feline solar-induced facial squamous cell carcinomas (SCCs). The objective of this study was to provide preliminary data on the use and safety profile of coarse fractions administered with an SBRT regime to manage advanced-stage feline solar-induced facial SCCs. Methods This retrospective study assessed five cats diagnosed with advanced-stage solar-induced facial SCCs that received SBRT as their primary treatment or, in one cat, following failed surgical intervention. Tumour sites received three fractions totalling 26.25–27 Gy over a 3–5-day period. Results All patients developed acute effects following SBRT including alopecia, epilation and erythema. Late effects were mild and included alopecia, variable pigmentation and leukotrichia within radiation fields. All patients are currently alive at the time of submission, with overall survival times ranging from 118 to 991 days. Conclusions and relevance The results suggest that coarse fractions administered with an SBRT technique is a safe and effective treatment tool for the management of advanced-stage feline solar-induced facial SCCs. These data provide preliminary evidence to support larger, prospective studies evaluating the management of feline facial SCCs with SBRT.

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Prognostic factors for cats with squamous cell carcinoma of the nasal planum following high-dose rate brachytherapy

Cited by 6 publications

References 58 publications

Tumor prevalence in cats: experience from a reference diagnostic center in Mexico City (2006-2018)

Tumor prevalence in cats: experience from a reference diagnostic center in Mexico City (2006-2018)

Marginal resection and infracyanine green‐mediated photodynamic therapy in the management of feline eyelid squamous cell carcinoma: Two cases

Pilot study evaluating stereotactic body radiation therapy for feline facial squamous cell carcinomas

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