Prognostic factors at birth for stunting at 24 months of age in rural Indonesia

Prawirohartono, Endy Paryanto; Nurdiati, Detty Siti; Hakimi, Mohammad

doi:10.14238/pi56.1.2016.09

“…Tingginya tekanan darah disamping menyebabkan eklamsi, juga menyebabkan hasil janin yang lebih buruk, termasuk berat badan lahir rendah, skor Apgar rendah, dan komplikasi pada kehamilan. Hal ini sejalan dengan banyak penelitian lain yang menyatakan bahwa tekanan darah ibu yang tinggi dikaitkan dengan peningkatan risiko pertumbuhan janin terhambat, kelahiran prematur, dan masalah pernapasan pada bayi baru lahir, terkait dengan gangguan aliran darah pada janin dan plasenta (Prawirohartono et al, 2016;.…”

Section: Gambar 1 Penyuluhan Pencegahan Stunting Melalui Pola Asuh Ib...unclassified

Prevention of Stunting through Improving Maternal Parenting and Early Detection of Pregnancy Risk Factors

Pranata

¹

,

Yuniawati

²

,

Robbika

³

et al. 2022

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According to recommendations from the Jember Regency Government and the results of a field survey, stunting is one of the most pressing issues facing the community, particularly in the deployment area of Kemuningsari Kidul Village, Jenggawah, Jember. As part of an activity program, the villagers of Kemuningsari Kidul will receive counseling to prevent stunting by enhancing maternal parenting and detecting pregnancy risk factors early on. This activity aims to increase pregnant women's knowledge of stunting, preventative measures, and the definition of stunting in order to eliminate confusion among mothers. It is hoped that the program will be able to reduce the incidence of stunting in Jember and prevent its recurrence.

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Effect of lactoferrin in oral nutrition supplement (ONS) towards IL-6 and IL-10 in failure to thrive children with infection

Widjaja,

Hamidah,

Purnomo

et al. 2023

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Background: Growth failure due to infection in children is a major health problem throughout the world. It provokes a systemic immune response, with increased interleukin (IL)-6 and reduced IL-10. Lactoferrin (Lf) is a multifunctional iron-binding protein that can be found in whey protein inside formula milk such as oral nutrition supplement (ONS), which can upregulate anti-inflammatory cytokines (IL-10) and modulate pro-inflammatory cytokines. This study investigates the effect of Lf supplementation in ONS on IL-6 and IL-10 levels in children with failure to thrive and infection. Methods: We performed a quasi-experimental pre- and post-study in children aged 12–60 months old with failure to thrive due to infectious illness. The subjects received 400 ml of oral nutritional supplements (ONS, 1 ml equivalent to 1 kcal) each day for 90 days, and their parents received dietary advice and medication based on the underlying illness. Blood was drawn to measure IL-6 and IL-10 before and after the intervention. Results: There were 75 subjects recruited and divided into group-1 and group-2 based on age. The incidence of undernutrition was 37.33%. Lf in ONS intervention improved body weight and body length. Lf also reduced IL-6, although there was not a significant difference before and after the intervention. However, the IL-6 reduction was significantly higher in subjects with undernutrition compared with subjects with weight faltering. Pre-intervention IL-6 levels were higher in children with stunting than in children with normal stature. There was a greater change in IL-6 in children with severe stunting than in children with normal stature or stunting. IL-10 was significantly reduced after the intervention. Conclusions: In addition to improving body weight and length, Lf supplementation in ONS improved immune response homeostasis by balancing IL-6 and IL-10 levels and by improving the IL-6/IL-10 ratio. ClinicalTrials.gov number ID: NCT05289674, dated May 3rd 2022.

show abstract

Effect of lactoferrin in oral nutrition supplement (ONS) towards IL-6 and IL-10 in failure to thrive children with infection

Widjaja,

Hamidah,

Purnomo

et al. 2023

F1000Res

0

View full text Add to dashboard Cite

Background: Growth failure due to infection in children is a major health problem throughout the world. It provokes a systemic immune response, with increased interleukin (IL)-6 and reduced IL-10. Lactoferrin (Lf) is a multifunctional iron-binding protein that can be found in whey protein inside formula milk such as oral nutrition supplement (ONS), which can upregulate anti-inflammatory cytokines (IL-10) and modulate pro-inflammatory cytokines. This study investigates the effect of Lf supplementation in ONS on IL-6 and IL-10 levels in children with failure to thrive and infection. Methods: We performed a quasi-experimental pre- and post-study in children aged 12–60 months old with failure to thrive due to infectious illness. The subjects received 400 ml of oral nutritional supplements (ONS, 1 ml equivalent to 1 kcal) each day for 90 days, and their parents received dietary advice and medication based on the underlying illness. Blood was drawn to measure IL-6 and IL-10 before and after the intervention. Results: There were 75 subjects recruited and divided into group-1 and group-2 based on age. The incidence of undernutrition was 37.33%. Lf in ONS intervention improved body weight and body length. Lf also reduced IL-6, although there was not a significant difference before and after the intervention. However, the IL-6 reduction was significantly higher in subjects with undernutrition compared with subjects with weight faltering. Pre-intervention IL-6 levels were higher in children with stunting than in children with normal stature. There was a greater change in IL-6 in children with severe stunting than in children with normal stature or stunting. IL-10 was significantly reduced after the intervention. Conclusions: In addition to improving body weight and length, Lf supplementation in ONS improved immune response homeostasis by balancing IL-6 and IL-10 levels and by improving the IL-6/IL-10 ratio. ClinicalTrials.gov number ID: NCT05289674, dated May 3rd 2022.

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Prognostic factors at birth for stunting at 24 months of age in rural Indonesia

Abstract: Background The problems of stunting are its high prevalence as

Cited by 4 publications

References 25 publications

Prevention of Stunting through Improving Maternal Parenting and Early Detection of Pregnancy Risk Factors

Prevention of Stunting through Improving Maternal Parenting and Early Detection of Pregnancy Risk Factors

Effect of lactoferrin in oral nutrition supplement (ONS) towards IL-6 and IL-10 in failure to thrive children with infection

Effect of lactoferrin in oral nutrition supplement (ONS) towards IL-6 and IL-10 in failure to thrive children with infection

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