Prognostic Factors and Treatment Outcomes for Anaplastic Thyroid Carcinoma: ATC Research Consortium of Japan Cohort Study of 677 Patients

Sugitani, Iwao; Miyauchi, Akira; Sugino, Kiminori; Okamoto, Takahiro; Yoshida, Akira; Suzuki, Shinichi

doi:10.1007/s00268-012-1437-z

Cited by 228 publications

(256 citation statements)

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“…To date, fewer than 20 cases of anaplastic transformation at the metastatic sites have been reported in the English literature [1,[4][5][6][7][8][9][10][11]. Here, we report an additional case of anaplastic transformation which developed in the pleural metastasis, combined with a literature review.…”

Section: Introductionmentioning

confidence: 99%

“…Although anaplastic transformation rarely occurs, anaplastic carcinoma is one of the most aggressive cancers, and is responsible for more than half of the deaths attributed to thyroid cancers, with a mean survival time of 6 months after diagnosis [3]. Anaplastic transformation commonly occurs in the thyroid and metastatic regional lymph nodes, whereas occurrence at distant metastatic sites is extremely rare [4]. Among 677 cases of anaplastic thyroid carcinoma (ATC), collected from 38 registered institutions by the ATC Research Consortium of Japan (ATCCJ), only 6 cases showed anaplastic transformation at the metastatic sites (0.9 %), and these had the worst outcomes among all ATC cases [4].…”

Section: Introductionmentioning

confidence: 99%

“…Anaplastic transformation commonly occurs in the thyroid and metastatic regional lymph nodes, whereas occurrence at distant metastatic sites is extremely rare [4]. Among 677 cases of anaplastic thyroid carcinoma (ATC), collected from 38 registered institutions by the ATC Research Consortium of Japan (ATCCJ), only 6 cases showed anaplastic transformation at the metastatic sites (0.9 %), and these had the worst outcomes among all ATC cases [4].…”

Section: Introductionmentioning

confidence: 99%

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Anaplastic Transformation of Papillary Thyroid Carcinoma Only Seen in Pleural Metastasis: A Case Report with Review of the Literature

Kim

Park

et al. 2016

Head and Neck Pathol

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Anaplastic transformation of papillary thyroid carcinoma (PTC) at distant metastatic sites is extremely rare, and there have been fewer than 20 reported cases in the literature. A 61-year-old woman presented with 1-week history of dyspnea. Her past medical history was remarkable because, 19 years ago, she underwent nearly total thyroidectomy and radical neck dissection due to PTC. Computed tomography of the chest revealed a 1.7 cm nodule in the lung and diffuse pleural thickening. Gun biopsy of the lung nodule revealed metastatic PTC with typical histology. However, the pleural biopsy predominantly showed anaplastic pleomorphic and spindle sarcomatoid carcinoma with microscopic focus of PTC. Immunohistochemical results showed both anaplastic sarcomatoid and PTC components positive for TTF-1, galectin-3 and PAX-8, thus supporting anaplastic transformation of PTC at the metastatic site. Subsequently the patient received 1 cycle of cisplatin-based chemotherapy but died from the disease 4 months after diagnosis. Although it is rare, anaplastic transformation of PTC should be considered during differential diagnosis of patients who present with exclusive sarcomatoid morphology at metastatic sites and have a history of PTC. We report another case of anaplastic transformation of PTC, found at pleural metastasis, together with the immunohistochemical profile and a literature review.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anaplastic Transformation of Papillary Thyroid Carcinoma Only Seen in Pleural Metastasis: A Case Report with Review of the Literature

Kim

Park

et al. 2016

Head and Neck Pathol

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“…In previous studies, long-term survival is possible when patient is younger age and tumor has smaller size, localizes in thyroid parenchyma and can be completely resected by surgery. [2][3][4] Currently, it is generally accepted that ATC does not arise de novo but rather transforms or evolves from differentiated thyroid carcinoma (DTC). 5,6) ATC is commonly related with previous or concurrent thyroid disorders, including DTC.…”

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics and Prognosis of Differentiated Thyroid Carcinoma with Small Foci of Anaplastic Transformation

et al. 2017

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Background and Objectives: Anaplastic thyroid carcinoma (ATC) is commonly related with concurrent differentiated thyroid carcinoma (DTC). We aimed to examine the clinicopathologic characteristics, prognosis and gene expression of DTC with anaplastic foci. Materials and Methods: Eighteen patients with DTC with anaplastic foci were enrolled in this study. To compare the clinicopathologic characteristics and prognosis of anaplastic foci subjects with conventional ATC or DTC, we additionally included 12 ATC and 1030 DTC patients who diagnosed during same period. Immunohistochemistry was performed to check the gene expression in anaplastic foci and DTC component. Results: In anaplastic foci group, tumor size was larger (2.5±1.3 vs. 1.2±0.9 cm, p=0.001), distant metastasis was more frequent (11.1 vs. 0%, p=0.000) and 1-year survival rate was low (88.9 vs. 100%, p=0.000) than DTC group. In contrast, compared with ATC group, anaplastic foci group showed younger age at diagnosis (50±16 vs. 63±18 years, p=0.039), smaller tumor size (2.5±1.3 vs. 3.8±1.4 cm, p=0.027), less distant metastasis (11.1 vs. 41.7%, p=0.084) and longer 1-year survival rate (88.9 vs. 25.0%, p=0.001). Expression of p53 protein was observed in 100% of anaplastic foci, ATC and 12.5% of papillary thyroid carcinoma component. Conclusion: DTC with foci of anaplastic transformation has a worse prognosis than DTC, but a better prognosis than ATC. Our results support that DTC with anaplastic foci was intermediate state from DTC to ATC.

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“…Sugitani et al identified age and limited tumor size which is associated with higher tumor resectability as prognostic variables 24 . Liu et al reported that tumor size < 4 cm, distant spread, surgical resection, RT and residual tumor were independent factors of prognosis of ATC patients who underwent treatment 16 .…”

mentioning

confidence: 99%

Treatment Outcome and Prognostic Factors of Anaplastic Thyroid Carcinoma: A Single Institution Experience in Egypt

Ibrahim

Askoura

2018

Kasr-Al-Aini J.of Clin. Onc. and Nuc. Med.

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Introduction: Anaplastic thyroid carcinoma (ATC) is a rare lethal malignancy. It is one of the most aggressive human malignancies with limited progress in finding effective therapies. Aim: We aimed to study the treatment outcome and prognostic factors of ATC patients treated at our institution. Methods: We retrospectively analyzed charts of 30 ATC patients, treated at the Clinical Oncology Department, AinShams University from 2006 to 2017. The clinical characteristics and factors affecting survival were studied. Kaplan-Meier survival curve was used to analyze the overall survival (OS) of the patients. Results: The median age of patients was 60 years and males represented 63% of them. Almost half of patients (47%) had stage IVA disease. Equal number of patients received combined modality treatment versus single modality treatment (37% each). The median OS was 3 months (95% Confidence interval: 1.429-4.571). Variables associated with significantly better OS in univariate analysis included male sex (p=0.04), stage IVA disease (p=0.012), surgical treatment (p=0.034), radiotherapy (p=0.003), and combined modality treatment (p=0.005). However, only female sex was identified as significant poor prognostic variable of OS (p=0.043) by multivariate analysis. Conclusion: Our results of treatment outcome and prognosis of ATC agree with most of the literature. Multimodality treatment is currently the standard of care. While still there is no successful treatment of this rapidly fatal disease, exploration of novel therapies and approaches are warranted to help improve the outcome.

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Prognostic Factors and Treatment Outcomes for Anaplastic Thyroid Carcinoma: ATC Research Consortium of Japan Cohort Study of 677 Patients

Abstract: Long-term survival is possible for selected patients with ATC. To determine the treatment strategy, UICC stage (disease extent) and other prognostic factors (e.g., biologic malignancy grade) should be considered.

Cited by 228 publications

References 34 publications

Anaplastic Transformation of Papillary Thyroid Carcinoma Only Seen in Pleural Metastasis: A Case Report with Review of the Literature

Anaplastic Transformation of Papillary Thyroid Carcinoma Only Seen in Pleural Metastasis: A Case Report with Review of the Literature

Clinical Characteristics and Prognosis of Differentiated Thyroid Carcinoma with Small Foci of Anaplastic Transformation

Treatment Outcome and Prognostic Factors of Anaplastic Thyroid Carcinoma: A Single Institution Experience in Egypt

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