Prognostic factors and the therapeutic strategy for patients with bone metastasis from differentiated thyroid carcinoma

Orita, Yorihisa; Sugitani, Iwao; Matsuura, M.; Ushijima, Masaru; Tsukahara, Kiyoaki; Fujimoto, Yoshihide; Kawabata, Kazuyoshi

doi:10.1016/j.surg.2009.10.009

Cited by 83 publications

(85 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Distant metastasis of DTC was known to occur in 5-25% of patients and is the main cause of cancer-related death (3,4). After the lungs, bone is the second most common site of distant neurological deficits, and deteriorated quality of life (5,10). A recent study reported that 78% of thyroid cancer patients with bone metastases developed at least one skeletal-related event (SRE) during median 4.9 years of follow-up period, and mortality was significantly higher in patients with bone metastases who developed SREs (10).…”

Section: Introductionmentioning

confidence: 99%

“…Most previous studies categorize metastatic lesions as synchronous or metachronous (5,9,11,12). Synchronous metastasis is defined as the presence of a distance metastasis at the time of, or within a few months of, the initial diagnosis and includes patients whose metastatic lesions were found on the initial post-therapeutic wholebody scan (WBS) (RxWBS) after radioactive iodine (RAI) therapy (RAIT).…”

Section: Introductionmentioning

confidence: 99%

“…Metachronous metastasis is defined as distant metastasis found during the follow-up. However, patients who have no symptoms or SRE and just detected bone metastasis by initial RAIT demonstrate excellent responses to RAIT and much better survival than patients who demonstrate bone metastasis before the initial RAIT (5,13). Furthermore, patients who demonstrate bone metastasis through an initial RAIT often include bone metastasis with no structural correlation, which is known to have no prognostic significance (14).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Early prognostic factors at the time of diagnosis of bone metastasis in patients with bone metastases of differentiated thyroid carcinoma

Choi

Kim²,

Kwon³

et al. 2016

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: Bone is the second most common site of distant metastases from differentiated thyroid cancer (DTC). Patients with bone metastases were associated with poor clinical outcomes; however, their clinical courses are heterogeneous. The aim of this study is to evaluate early prognostic factors of patients with bone metastases from DTC at the time of diagnosis of bone metastasis. Methods: This retrospective study included 93 patients with bone metastases from DTC. We defined 'Pre-RAIT group' as patients whose bone metastases were detected before initial RAIT. The 'post-RAIT group' was defined as patients whose bone metastases were detected after initial RAIT or during the follow-up period. Results: Median age was 55.4 years, and 55 patients (59%) had papillary thyroid cancer. Patients in the pre-RAIT group (n = 32) demonstrated significantly poorer overall survival (OS) (HR = 1.86, P = 0.04) than those in the post-RAIT group. There was no significant difference in the OS according to the initial RAI avidity among all patients (P = 0.18). RAI-avid bone metastases had better OS only in the pre-RAIT group (HR = 0.23, P = 0.01) but not in the post-RAIT group. In the post-RAIT group, older age (>45 years), elevated serum thyroglobulin (Tg) level (>250 ng/mL), and the presence of skeletal-related events (SREs) were significantly associated with poor OS. RAI avidity was not a significant prognostic factor in the post-RAIT group (P = 0.33). Conclusions: Patients whose bone metastases were diagnosed before initial RAIT demonstrate a poorer prognosis. RAI avidity is an early prognostic indicator in the pre-RAIT group. Old age, higher serum Tg levels, and SRE are associated with poor survival outcomes in the post-RAIT group.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Early prognostic factors at the time of diagnosis of bone metastasis in patients with bone metastases of differentiated thyroid carcinoma

Choi

Kim²,

Kwon³

et al. 2016

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Bone metastases are usually seen in about 1-3 % of the well-differentiated thyroid carcinomas, occurring more often in follicular carcinomas and in patients more than 40 years of age [10]. Although a majority of the skeletal metastasis from thyroid cancers can be effectively managed by radioactive iodine ablations or external beam radiation, some authors do recommend surgery in the event of a solitary, accessible metastatic lesion [10]. The lack of large numbers of patients with jaw metastasis prevents accurate determination of the prognosis of follicular thyroid carcinomas after metastatectomy [10].…”

Section: Discussionmentioning

confidence: 99%

“…Although a majority of the skeletal metastasis from thyroid cancers can be effectively managed by radioactive iodine ablations or external beam radiation, some authors do recommend surgery in the event of a solitary, accessible metastatic lesion [10]. The lack of large numbers of patients with jaw metastasis prevents accurate determination of the prognosis of follicular thyroid carcinomas after metastatectomy [10]. A few reports have none the less suggested that metastatectomy of a jaw tumor from a thyroid primary carries a much better prognosis when compared to the other primaries sites [9].…”

Section: Discussionmentioning

confidence: 99%

Metastatic Follicular Carcinoma Thyroid Masquerading as a Primary Jaw Tumor

Deen

Ramshankar

Majhi

2015

J. Maxillofac. Oral Surg.

View full text Add to dashboard Cite

Metastatic tumours of the oral cavity are rare constituting approximately one percent of all oral malignancies. These tumors are clinically significant as their appearance may be the first indication of an undiscovered malignancy at a distant primary site or the first evidence of dissemination from a known primary tumor. Thyroid cancer metastasizing to the jaw bones is a rare occurrence and very few cases have been described in literature. We present an additional case which in fact masqueraded as a primary jaw tumor. Metastasis to jaw bones is generally associated with poor prognosis with a majority of the patients dying within 6 months of diagnosis. Thyroid cancers however seem to be an exception to this, resectable solitary jaw bone metastasis from differentiated thyroid cancers is associated with a much better prognosis and therefore should be considered for metastatectomy.

show abstract

Machine learning for the prediction of bone metastasis in patients with newly diagnosed thyroid cancer

Liu

Luo

et al. 2021

Cancer Medicine

View full text Add to dashboard Cite

Objectives This study aimed to establish a machine learning prediction model that can be used to predict bone metastasis (BM) in patients with newly diagnosed thyroid cancer (TC). Methods Demographic and clinicopathologic variables of TC patients in the Surveillance, Epidemiology, and End Results database from 2010 to 2016 were retrospectively analyzed. On this basis, we developed a random forest (RF) algorithm model based on machine‐learning. The area under receiver operating characteristic curve (AUC), accuracy score, recall rate, and specificity are used to evaluate and compare the prediction performance of the RF model and the other model. Results A total of 17,138 patients were included in the study, with 166 (0.97%) developed bone metastases. Grade, T stage, histology, race, sex, age, and N stage were the important prediction features of BM. The RF model has better predictive performance than the other model (AUC: 0.917, accuracy: 0.904, recall rate: 0.833, and specificity: 0.905). Conclusions The RF model constructed in this study could accurately predict bone metastases in TC patients, which may provide clinicians with more personalized clinical decision‐making recommendations. Machine learning technology has the potential to improve the development of BM prediction models in TC patients.

show abstract

Prognostic factors and the therapeutic strategy for patients with bone metastasis from differentiated thyroid carcinoma

Cited by 83 publications

References 25 publications

Early prognostic factors at the time of diagnosis of bone metastasis in patients with bone metastases of differentiated thyroid carcinoma

Early prognostic factors at the time of diagnosis of bone metastasis in patients with bone metastases of differentiated thyroid carcinoma

Metastatic Follicular Carcinoma Thyroid Masquerading as a Primary Jaw Tumor

Machine learning for the prediction of bone metastasis in patients with newly diagnosed thyroid cancer

Contact Info

Product

Resources

About