Prognostic factors and survival according to tumour subtype in women presenting with breast cancer bone metastases at initial diagnosis: a SEER-based study

Li, Xiao; Zhang, Xiaoli; Liu, Jie; Shen, Yinzhong

doi:10.1186/s12885-020-07593-8

Cited by 17 publications

(24 citation statements)

References 31 publications

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“…Previous studies focused on BCBM patients of all ages confirmed that lung metastases was an independent risk factors. 32 , 33 Combined with the results of this study, we found that lung metastasis appears to be an age-specific prognostic factor for BCBM patients. However, the mechanism of this results needs to be further studied and whether this phenomenon also exists in other tumors deserves further study.…”

Section: Discussionsupporting

confidence: 76%

Development and Validation of Prognostic Nomogram for Elderly Breast Cancer: A Large-Cohort Retrospective Study

Li¹,

Zhang²

2022

IJGM

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Purpose: Our research aims to study the bone metastatic patterns and prognostic outcomes in elderly breast cancer (BC) and to develop elder-specific nomograms. Methods: We downloaded the data of BC patients between 2010 and 2016 from the Surveillance, Epidemiology, and End Results database. The differences in clinical features and prognosis between young (age < 65) and elderly (age ≥ 65) BC patients were compared. The univariate and multivariate Cox analyses were used to determine the overall survival (OS)-and cancer-specific survival (CSS)-related variables and establish two nomograms of BC patients with bone metastasis (BCBM). The receiver operating characteristic (ROC) curve with area under the curve (AUC), calibration curve, decision curve analysis (DCA), and Kaplan-Meier survival curve were selected to evaluate nomograms. Results: A total of 230,177 BC patients were enrolled in our research, including 142,025 young and 88,152 elderly patients. The prognosis of elderly BCBM patients was significantly worse than young patients. Age, race, breast subtype, tumor size, tumor grade, brain metastasis, liver metastasis, surgery, and chemotherapy were independent prognostic variables for elderly BCBM patients, including OS and CSS. The AUC values at 12, 18, and 24 months were 0.750, 0.751, and 0.739 for OS nomogram and 0.759, 0.762, and 0.752 for CSS nomogram in the training cohort, which were higher than the AUC values of all single independent prognostic variables. The survival curve showed a distinct prognosis between low-, median-and high-risk groups (p < 0.001). Finally, calibration curves and DCA indicated that both nomograms have favorable performance. Conclusion:Elderly and young patients presented with different bone metastatic frequencies, clinical features, and prognostic outcomes. Two elder-specific nomograms incorporating nine clinical variables were established and validated to be a valuable predictor for elderly BCBM patients.

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Section: Discussionsupporting

confidence: 76%

Development and Validation of Prognostic Nomogram for Elderly Breast Cancer: A Large-Cohort Retrospective Study

Li¹,

Zhang²

2022

IJGM

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“…A significant difference in survival was not revealed among various races, which was congruent with some previous studies ( 13 , 17 ). However, other studies found race was an independent prognostic factor among BC with bone metastasis ( 15 , 16 ). Tumor grade is usually recognized as an independent risk factor for the prognosis of BC ( 16 , 18 ).…”

Section: Discussionmentioning

confidence: 87%

“…On the whole, the prognosis of male BC with bone metastasis (3-year OS and CSS rates: 36.7% and 39.5%) was worse than that of female patients (3-year OS and CSS rates: 51.7% and 53.6%) ( 13 ), suggesting that the prognosis and treatments of such patients need more attention. Previous studies indicated that older BC patients were prone to bone metastasis ( 14 ) and age was an important independent predictor of survival ( 15 , 16 ). Our multivariable results also highlighted this finding in male BC patients with bone metastasis.…”

Section: Discussionmentioning

confidence: 99%

Survival Analysis in Male Breast Cancer With Bone Metastasis Based on the SEER Database

et al. 2022

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PurposeBreast cancer (BC) has been extensively and deeply studied as the number one malignant tumor in women, but its status in male patients, especially in male metastatic patients, is rarely reported. Thus, this study aimed to explore the prognosis and risk factors of male BC with bone metastasis.Patients and MethodsWe searched the Surveillance, Epidemiology, and End Results (SEER) database to identify all patients diagnosed with male BC with bone metastasis from 2010 to 2016. Risk factors of overall survival (OS) and cancer-specific survival (CSS) were analyzed by univariable and multivariable Cox analyses. We also drew Kaplan–Meier plots to show the correlation between independent risk factors and survival.ResultsA total of 207 male BC patients with bone metastasis were included for analysis. Approximately one-third of patients also had lung metastasis. Luminal A subtype comprised 58.5% of the overall patient population. These patients had a poor prognosis, with 3-year OS and CSS rates, 36.7% and 39.5%, respectively. Further analysis revealed that age ≤60 years old, luminal A or B, and surgery were independent predictors of prolonged OS and CSS. On Cox multivariable analysis, brain metastasis was associated with OS and not CSS.ConclusionWe identified four independent factors associated with prognosis in male BC patients with bone metastasis, namely age, tumor subtype, surgery, and brain metastasis. Knowing these risk factors will help clinicians make more appropriate treatment plans.

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“…Previous studies have shown that race is an independent risk factor that affects the occurrence and prognosis of breast cancer bone metastases. 9 , 10 Therefore, the establishment of risk and prognostic models for Asian females with BCBM is conducive to more precise and individualized prevention and treatment of this disease.…”

Section: Introductionmentioning

confidence: 99%

Construction and Validation of New Nomograms to Predict Risk and Prognostic Factors of Breast Cancer Bone Metastasis in Asian Females: A Population-Based Retrospective Study

Deng¹,

Zhang²,

Zhang³

et al. 2021

IJGM

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Purpose To construct a breast cancer bone-only metastasis (BCBM) risk and prognostic model for Asian females and provide a reference for treatment selection in breast cancer (BC) patients with bone-only metastasis (BM). Patients and Methods The data for newly diagnosed female patients of Asian Pacific Islander (API) ethnicity between 2010 and 2018 were obtained from the Surveillance, Epidemiology, and End Results database. A total of 16,972 patients were identified. Logistic regression analyses were used to establish a risk model for BCBM. Cox proportional hazards regression analyses were used to construct nomograms for the prognosis of BC and BCBM. Subsequently, the degree of discrimination of the nomogram was evaluated using the consistency index (C-index) and receiver operating curve. Results The main independent risk factors of BM in Asian females with BC were primary site surgery (p<0.0001), ER (p=0.0015), and T-stage (p=0.0046). The C-index values in the training and validation cohorts were 0.933 and 0.941, respectively. The main independent risk factors of the prognosis of BC were age (p<0.001), summary stage (p<0.001), and grade (p=0.002). The C-index values of 5-year overall survival (OS) in the training and validation cohorts were 0.823 and 0.804, respectively. The risk factors of the prognosis of Asian females with BCBM were subtype (p<0.001), histology (p<0.001), and grade (p=0.033). The C-index values of 5-year OS in the training and validation cohorts were 0.793 and 0.723, respectively. Conclusion Using population-based analysis, this study constructed a prediction model for the risk and prognosis of BM in Asian females with BC. Another newly constructed model was effective in predicting OS in BCBM patients. These models can help prevent skeletal-related events and weigh the risks and benefits of surgery for metastatic lesions in BCBM patients.

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Prognostic factors and survival according to tumour subtype in women presenting with breast cancer bone metastases at initial diagnosis: a SEER-based study

Cited by 17 publications

References 31 publications

Development and Validation of Prognostic Nomogram for Elderly Breast Cancer: A Large-Cohort Retrospective Study

Development and Validation of Prognostic Nomogram for Elderly Breast Cancer: A Large-Cohort Retrospective Study

Survival Analysis in Male Breast Cancer With Bone Metastasis Based on the SEER Database

Construction and Validation of New Nomograms to Predict Risk and Prognostic Factors of Breast Cancer Bone Metastasis in Asian Females: A Population-Based Retrospective Study

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