Prognostic factors and predictive tools for upper tract urothelial carcinoma: a systematic review

Mbeutcha, Aurélie; Rouprêt, Morgan; Kamat, Ashish M.; Karakiewicz, Pierre I.; Lawrentschuk, Nathan; Novara, Giacomo; Raman, Jay D.; Seitz, Christian; Xylinas, Évanguelos; Shariat, Shahrokh F.

doi:10.1007/s00345-016-1826-2

Cited by 81 publications

(54 citation statements)

References 116 publications

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“…Increased laboratory values (neutrophils, C reactive protein) as a result of inflammatory processes may be predictive factors for tumor invasiveness or aggressiveness (11). The most studied biomarker of inflammation is the neutrophil-lymphocyte ratio (NLR), which was shown to be a prognostic factor in pancreas, breast, colon neoplasm (12) and tumors of urological origin, such as renal cell carcinoma (13) and urothelial carcinomas (14)(15)(16)(17). Thus, there has been no focus on low-risk NMIBC.…”

Section: Introductionmentioning

confidence: 99%

The role of neutrophil to lymphocyte ratio in patients with pTa non-muscle invasive bladder cancer

Martha

Bălan

Porav-Hodade

et al. 2020

Revista Romana De Medicina De Laborator

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Introduction:The peritumoral inflammatory reaction has a substantial importance in the oncologic outcome of bladder cancer (BC). One biomarker proven to be practical and accessible is the NLR (neutrophil-to-lymphocyte ratio) for high risk non-muscle invasive bladder cancer (NMIBC). The aim of the study was to investigate the role of NLR as a prognostic biomarker for disease recurrence, progression and survival of p Ta (pathological assesment of the primary tumor) NMIBC. Material and Methods: In our retrospective study we included 54 patients with pTa NMIBC from a total of 235 patients who underwent transurethral resection of bladder tumor (TURBT) during two consecutive years: January 2007 -December 2008]. Criteria for inclusion were: primary tumor, low-grade, with NLR available at 2 weeks prior to TURBT. NLR was considered altered if higher than 3. Results: The median age of the patients included was 63 years ). Most of the patients had NLR<3 (37 patients). Median EORTC (European Organization of Research and Treatment of Cancer) Recurrence Score was 4 (IQR 1-6), while EORTC Progression Score was 3 (IQR 0-6), respectively. Recurrence occurred in 8 out of 54 (14.81 %) patients and progression was identified in 2 out of 54 (3.70 %) patients with muscle-invasive BC during follow-up. NLR>3 was not associated with clinical and pathological factors. In multivariable Cox regression analyses NLR as a continuous variable was an independent predictive factor for recurrence. Recurrence-free survival (RFS) Kaplan-Meier analysis did not show a statistical significance between NLR groups: 82.67% vs. 64.12%, p=0.26. Kaplan-Meier analysis showed a lower Progression-free survival (PFS) in the NLR>3 group: 94.12% vs. 100%, p=0.04. During follow-up (106 months) 18 patients deceased with

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Section: Introductionmentioning

confidence: 99%

The role of neutrophil to lymphocyte ratio in patients with pTa non-muscle invasive bladder cancer

Martha

Bălan

Porav-Hodade

et al. 2020

Revista Romana De Medicina De Laborator

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“…Neutrophil-to-lymphocytes ratio has been described as a prognostic factor in many other malignancies such as pancreatic, breast and colon (8). In urological carcinomas the importance of NLR has been described in bladder cancer (9), renal cell carcinoma (10) and upper tract urothelial carcinoma (11,12).…”

Section: Introductionmentioning

confidence: 99%

Easily Available Blood Test Neutrophil-To-Lymphocyte Ratio Predicts Progression in High-Risk Non-Muscle Invasive Bladder Cancer

Martha

Porav-Hodade

Bălan

et al. 2017

Revista Romana De Medicina De Laborator

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“…UC can be found in the renal collecting system or ureter but is most common in the bladder epithelium. The most important patient factors that are predictive of outcomes in a recent systematic review were male sex, advanced age, tobacco exposure, diabetes mellitus with poor glycemic control, and CKD …”

Section: Urothelial Carcinoma and Bladder Cancermentioning

confidence: 99%

Urologic malignancies in kidney transplantation

Hickman

Sawinski

Guzzo

et al. 2018

American Journal of Transplantation

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With advances in immunosuppression, graft and patient outcomes after kidney transplantation have improved considerably. As a result, long-term complications of transplantation, such as urologic malignancies, have become increasingly important. Kidney transplant recipients, for example, have a 7-fold risk of renal cell carcinoma (RCC) and 3-fold risk of urothelial carcinoma (UC) compared with the general population. While extrapolation of data from the general population suggest that routine cancer screening in transplant recipients would allow for earlier diagnosis and management of these potentially lethal malignancies, currently there is no consensus for posttransplantation RCC or UC screening as supporting data are limited. Further understanding of risk factors, presentation, optimal management of, and screening for urologic malignancies in kidney transplant patients is warranted, and as such, this review will focus on the incidence, surveillance, and treatment of urologic malignancies in kidney transplant recipients.

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Prognostic factors and predictive tools for upper tract urothelial carcinoma: a systematic review

Cited by 81 publications

References 116 publications

The role of neutrophil to lymphocyte ratio in patients with pTa non-muscle invasive bladder cancer

The role of neutrophil to lymphocyte ratio in patients with pTa non-muscle invasive bladder cancer

Easily Available Blood Test Neutrophil-To-Lymphocyte Ratio Predicts Progression in High-Risk Non-Muscle Invasive Bladder Cancer

Urologic malignancies in kidney transplantation

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