Prognostic factors and outcomes in primary urethral cancer: results from the international collaboration on primary urethral carcinoma

Gakis, Georgios; Morgan, Todd M.; Efstathiou, Jason A.; Keegan, Kirk A.; Mischinger, Johannes; Todenhoefer, Tilman; Schubert, Tina; Zaid, Harras B.; Hrbáček, Jan; Ali-El-Dein, Bedeir; Clayman, R.H.; Galland, Sigolene; Olugbade, Kola; Rink, Michael; Fritsche, Hans Martin; Burger, Maximilian; Chang, Sam S.; Babjuk, Marko; Thalmann, George N.; Stenzl, Arnulf; Daneshmand, Siamak

doi:10.1007/s00345-015-1583-7

Cited by 59 publications

(51 citation statements)

References 11 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our present study shows that the incidence of PUC was higher in men (63.4%), which is consistent with findings that 66.6% of men have a threefold higher incidence of PUC compared with women 13. In contrast, studies of 344 patients with PUC included in European cancer registries14 and a multi-institutional study of 154 patients with PUC6 did not detect a difference in OS between women and men. The median OS values of men and women were 21 months and 20 months, respectively, which supports the conclusion that women and men with PUC may experience similar durations of survival.…”

Section: Discussionsupporting

confidence: 92%

Sex-related differences in clinicopathological features and survival of patients with primary urethral carcinoma: a population-based study

Wei¹,

Wu²,

Xu³

et al. 2017

OTT

View full text Add to dashboard Cite

PurposeTo analyze the Surveillance, Epidemiology, and End Results (SEER) database to determine the effects of sex and prognostic factors on the survival of patients with primary urethral carcinoma (PUC).Materials and methodsWe selected 453 patients diagnosed with PUC from 2004 to 2013 from the SEER database. Statistical analysis was used to identify sex-specific differences associated with tumor characteristics and cancer-specific survival (CSS) and overall survival (OS).ResultsCompared with men, there was a higher proportion of black women, more negative lymph-node status, higher American Joint Committee on Cancer (AJCC) stage, more advanced T3 stage, more with adenocarcinoma (Ac), and fewer with squamous cell carcinoma (SCC) or transitional cell carcinoma (TCC). Among women, black race and M1 stage were associated with shorter CSS and OS, respectively. In addition, surgery was associated with longer OS in women. Among men, AJCC III and IV and M1 stages were associated with shorter CSS and OS. In addition, age >75 years associated with shorter OS in men.ConclusionBlack race was associated with shorter OS and CSS of women, and surgery was associated with longer OS of women. Among men, AJCC stage III and IV were associated with shorter OS and CSS. Age >75 years was associated with shorter OS in men only. Women with Ac experienced poor CSS compared with men. Men with TCC experienced worse CSS compared with those with Ac or SCC.

show abstract

Section: Discussionsupporting

confidence: 92%

Sex-related differences in clinicopathological features and survival of patients with primary urethral carcinoma: a population-based study

Wei¹,

Wu²,

Xu³

et al. 2017

OTT

View full text Add to dashboard Cite

show abstract

“…The incidence is higher in males and onset age is commonly in the 60s in both males and females. Regarding the histologic type, urothelial cancer is most frequent, accounting for 47–65% of cases, while squamous cell carcinoma accounts for 16–30%, although squamous cell carcinoma was the most frequent in males and females in one study …”

Section: Discussionmentioning

confidence: 90%

Primary male urethral squamous cell carcinoma presenting with a genital abscess

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Clinical nodal stage, tumor location and presence of synchronous BC were the only parameters found to be independently associated with RFS. Importantly, we recently reported that clinical nodal stage is a strong predictor for outcomes in primary urethral cancer [10] . As the number of events was low (n = 26 death events), we did not perform a multivariable analysis for OS.…”

Section: Discussionmentioning

confidence: 99%

Oncological Outcomes of Patients with Concomitant Bladder and Urethral Carcinoma

et al. 2016

Self Cite

View full text Add to dashboard Cite

chronous BC was diagnosed in 13 (12%) patients, and the median follow-up was 21 months (interquartile range 4-48). Urethral cancers were of higher grade in patients with synchronous BC compared to patients with non-synchronous BC (p = 0.020). Patients with synchronous BC exhibited significantly inferior 3-year recurrence-free survival (RFS) compared to patients with non-synchronous BC (63.2 vs. 34.4%; p = 0.026). In multivariable analysis, inferior RFS was associated with clinically advanced nodal stage (p < 0.001), proximal tumor location (p < 0.001) and synchronous BC (p = 0.020). Conclusion: The synchronous presence of BC in patients diagnosed with urethral carcinoma has a significant adverse impact on RFS and should be an impetus for a multimodal approach. © 2016 S. Karger AG, Basel Key WordsBladder cancer · Lymph node · Prognosis · Radical cystectomy · Risk factor · Survival · Urethra Abstract Introduction: The study aimed to investigate oncological outcomes of patients with concomitant bladder cancer (BC) and urethral carcinoma. Methods: This is a multicenter series of 110 patients (74 men, 36 women) diagnosed with urethral carcinoma at 10 referral centers between 1993 and 2012. Kaplan-Meier analysis was used to investigate the impact of BC on survival, and Cox regression multivariable analysis was performed to identify predictors of recurrence. Results: Syn-

show abstract

Prognostic factors and outcomes in primary urethral cancer: results from the international collaboration on primary urethral carcinoma

Abstract: These data suggest that clinical nodal stage is a critical parameter for outcomes in PUC.

Cited by 59 publications

References 11 publications

Sex-related differences in clinicopathological features and survival of patients with primary urethral carcinoma: a population-based study

Sex-related differences in clinicopathological features and survival of patients with primary urethral carcinoma: a population-based study

Primary male urethral squamous cell carcinoma presenting with a genital abscess

Oncological Outcomes of Patients with Concomitant Bladder and Urethral Carcinoma

Contact Info

Product

Resources

About