Prognostic factors and outcome of pelvic, sacral, and spinal chondrosarcomas

Bergh, Peter; Gunterberg, Björn; Meis‐Kindblom, Jeanne M.; Kindblom, Lars‐Gunnar

doi:10.1002/1097-0142(20010401)91:7<1201::aid-cncr1120>3.0.co;2-w

Cited by 213 publications

(172 citation statements)

References 37 publications

(30 reference statements)

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“…Only four patients in this series had chondrosarcoma, three of which arose in the pelvis and two had high-grade chondrosarcoma. Our results confirm the poor chemosensitivity and radiosensitivity of these tumours (Lee et al, 1999;Bergh et al, 2001): one of the two patients with high-grade chondrosarcoma had a measurable response after chemotherapy and the only patient in whom radiotherapy was delivered with a curative intent, relapsed 13 months later and died of disease. The most powerful prognostic factor concerning flat bone chondrosarcomas appeared to be the quality of the surgical resection.…”

Section: Discussionsupporting

confidence: 88%

“…In our study, 20% of the osteosarcomas were predominantly chondroblastic. Chondroblastic variants of osteosarcoma, such as chondrosarcoma, respond poorly to chemotherapy, with 3 -6.1% of total necrosis after initial chemotherapy (Ozaki et al, 1997;Bacci et al, 1998;Lee et al, 1999;Bacci et al, 2001;Bergh et al, 2001), whereas 39-52% of extremity osteosarcoma had 495% of tumour necrosis following preoperative chemotherapy (Sandoval et al, 1996;Bacci et al, 1998Bacci et al, , 2001. The excess incidence of the chondroblastic variant could then explain the poor chemosensitivity of flat bone osteosarcomas.…”

Section: Discussionmentioning

confidence: 99%

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Outcome of flat bone sarcomas (other than Ewing's) in children and adolescents: a study of 25 cases

Minard‐Colin

Kalifa

et al. 2004

Br J Cancer

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We analysed the clinical features and outcome of young patients with non-Ewing's flat bone sarcoma treated during the era of contemporary chemotherapy. The characteristics and outcome of 25 patients (15 males and 10 females) with primary or radiationrelated flat bone sarcoma treated in the Pediatrics Department at the Institut Gustave Roussy from 1981 to 1999 were reviewed. In all, 20 patients had osteosarcoma, four chondrosarcoma and one malignant fibrous histiocytoma. The age at diagnosis ranged from 2 to 23 years (median, 15 years). Nine tumours were located in the craniofacial bones, 11 in the pelvis and five in flat bones at other sites. Four patients had metastatic disease at diagnosis. Radiation-associated flat bone osteosarcoma was diagnosed in 10 out of 25 cases. The projected overall survival and event-free survival (EFS) rates at 5 years were 45.1 and 34.3% for all the 25 patients. The EFS rate of patients with second bone sarcoma was similar to that of patients with de novo flat bone sarcoma (P ¼ 0.1). The aim of treatment was curative for 24 patients, 23 of whom were treated with intensive chemotherapy regimens and 19 with surgery. Significant adverse prognostic factors on survival included incomplete surgical resection (P ¼ 0.001) and use of regimens without preand postoperative chemotherapy (P ¼ 0.007). Nine of the 25 patients were treated with pre-and postoperative chemotherapy and complete surgical resection. Among them, eight are alive with no disease. Radical surgical resection is the overriding prognostic factor for flat bone sarcomas in young patients. Nevertheless, our results suggest a more favourable outcome since the advent of intensive chemotherapy.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Outcome of flat bone sarcomas (other than Ewing's) in children and adolescents: a study of 25 cases

Minard‐Colin

Kalifa

et al. 2004

Br J Cancer

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“…Specific surgical strategies are delineated in the present report emphasizing the necessity of total removal, particularly considering tumor resistance to adjuvant therapy 19,20 .…”

Section: Manejo Dos Condrosarcomas Espinhais Primários: Relato De Doimentioning

confidence: 99%

“…However, limitations to total resection may involve risk of causing spinal instability and/or inflicting new deficits. Isolated cases of spinal chondrosarcomas have been reported [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] as well as a few series with limited number of patients [19][20][21][22] .…”

Section: Manejo Dos Condrosarcomas Espinhais Primários: Relato De Doimentioning

confidence: 99%

“…However, limitations to total resection may involve risk of causing spinal instability and/or inflicting new deficits. Isolated cases of spinal chondrosarcomas have been reported 2-18 as well as a few series with limited number of patients [19][20][21][22] .Specific surgical strategies are delineated in the present report emphasizing the necessity of total removal, particularly considering tumor resistance to adjuvant therapy 19,20 . …”

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confidence: 99%

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Management of primary spinal chondrosarcoma: report of two cases causing cord compression

Prevedello

Cordeiro

Koerbel

et al. 2004

Arq. Neuro-Psiquiatr.

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-Chondrosarcomas are malignant tumors that rarely grow inside the spinal canal. Prognosis depends on histological features, patient's age and surgical margins free from tumor. Response to radio and chemotherapy is poor. Ideal treatment consists of total "en-block" resection, not always achievable due to limitation of location, compromise of stability and risk of inducing neurological deficits. Two cases of spinal chondrosarcoma causing cord compression are reported, located in the cervical and thoracic spine. Microsurgical technique consisted of initial debulking followed by removal of margins until limits free from tumor were obtained. Total resection was accomplished and neurological function improved in both cases. Follow-up has been seven and one year respectively, with no evidence of recurrence and preserved neurological functions. Association between chondrosarcoma and estrogen-dependent tumor has been confirmed in this report. Although "en-block" resection of a chondrosarcoma should be tried whenever possible, tumor fragmentation should be considered in difficult cases, as in the present report, in which a long period free from recurrence with good quality of life can be obtained.KEY WORDS: chondrosarcoma, spinal neoplasms, spinal cord compression, microsurgery. Manejo dos condrosarcomas espinhais primários: relato de dois casos causando compressão medularRESUMO -Os condrosarcomas são tumores malignos, raramente localizados no interior do canal espinhal, com prognóstico dependente do grau histológico do tumor, idade do paciente e margens cirúrgicas livres. Esses tumores apresentam pouca resposta à radio e quimioterapia. O tratamento ideal consiste em ressecção tumoral em bloco, condição particularmente difícil em se tratando de tumores causando compressão medular, devido à localização da lesão, comprometimento da estabilidade axial e necessidade da manutenção ou recuperação da integridade da função neurológica do paciente. Relatamos dois casos de condrossarcomas causando compressão medular, um na coluna cervical e outro na torácica, submetidos a cirurgia com esvaziamento tumoral seguido de remoção das margens, atingindo-se ressecção total e melhora das funções neurológicas em ambos os casos. Um paciente se encontra há 7 anos e outro há 1 ano livre de recorrências, ambos com funções neurológicas preservadas. Associação entre condrosarcoma e tumor dependente de estrógeno é confirmada clinicamente pelo presente estudo. Embora uma ressecção em bloco dos condrossarcomas deva ser tentada quando possível, deve-se considerar uma ressecção com fragmentação tumoral em casos específicos, podendo-se atingir, como demonstrado nos presentes casos, períodos livres de recorrência e longo tempo de sobrevida. PALAVRAS-CHAVE: condrossarcoma, neoplasias medulares, compressão da medula espinhal, microcirurgia.Chondrosarcomas are malignant lesions, which represent the second most common tumor of the skeleton. However, presentation as primary tumor of the spine is extremely rare. These tumors can originate from healthy...

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Malignant sarcoma of the pelvic bones

Jawad

Haleem

Scully

2010

Cancer

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Incidence of pelvic sarcoma in 2006 was 89 per 100,000 persons; it has significantly increased since 1973 (P < .05). The overall 5-year survival for all the patients with pelvic sarcoma was 47%, with osteosarcoma having the worst 5-year survival at 19% and patients with chordoma having the best 5-year survival at 60%. Independent prognostic factors included age, stage, grade, size of primary lesion, histopathology, and treatment-related factors. Comparing the patients only with high-grade lesions, patients with Ewing sarcoma have the best prognosis. CONCLUSIONS: This is an analysis of patients with pelvic sarcomas derived from a population-based registry. Survival and prognostics vary with histopathological diagnoses. Although surgical resection was associated with superior outcomes for osteosarcoma and chondrosarcoma, there was no significant difference in outcomes of patients with Ewing sarcoma treated with surgery and/or radiotherapy. Cancer 2011;117:1529-41.

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Prognostic factors and outcome of pelvic, sacral, and spinal chondrosarcomas

Cited by 213 publications

References 37 publications

Outcome of flat bone sarcomas (other than Ewing's) in children and adolescents: a study of 25 cases

Outcome of flat bone sarcomas (other than Ewing's) in children and adolescents: a study of 25 cases

Management of primary spinal chondrosarcoma: report of two cases causing cord compression

Malignant sarcoma of the pelvic bones

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