Prognostic factors and outcome of Liposarcoma patients: a retrospective evaluation over 15 years

Knebel, Carolin; Lenze, Ulrich; Pohlig, Florian; Lenze, Florian; Harrasser, Norbert; Suren, Christian; Breitenbach, Jonathan E.; Rechl, H.; Eisenhart-Rothe, Rüdiger von; Mühlhofer, Heinrich

doi:10.1186/s12885-017-3398-y

Cited by 46 publications

(66 citation statements)

References 20 publications

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“…However, a clinical research of MLPS with 8 years of follow‐up reported that patients who accepted tumor resection with R1 margins had a similar recurrence rate to patients who accepted R0 margins. Another retrospective evaluation of clinical outcomes of liposarcoma patients over 15 years showed no statistically significant relationship between resection margins and patient survival. Wide resection is recommended for soft tissue sarcoma treatment, however, this is not feasible for some tumors with large diameters.…”

Section: Discussionmentioning

confidence: 99%

Surgical Outcomes and Prognostic Factors of Myxoid Liposarcoma in Extremities: A Retrospective Study

Zheng¹,

Yu²,

Xu³

et al. 2019

Orthopaedic Surgery

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ObjectivesTo evaluate treatments and prognostic factors for the myxoid liposarcoma in extremities.MethodsWe retrospectively reviewed 34 patients histologically diagnosed with myxoid liposarcoma arising in the extremities, treated in our hospital from 2010 to 2017. We recorded tumor locations, max diameter, operations, complications, radiation, chemotherapy, survival, recrudescence, and metastases. Overall survival, treatments, and prognostic factors were subsequently analyzed.ResultsThe mean age of 34 patients with myxoid liposarcoma in extremities was 49.1 years, and the mean follow‐up period was 65.1 months. The median survival time was 190 months. Five of 14 patients accepted recrudescence resection and two patients of 20 patients who underwent primary tumor resection or unplanned operation died of tumor progression. Although no statistical difference was found (X 2 = 3.331, P = 0.068), the lower mortality was confirmed in the patients who accepted primary tumor resection or unplanned operation. Eleven patients with a tumor diameter of 8.6 ± 4.7 cm accepted wide resection, while 23 patients with 17.2 ± 8.8 cm tumors accepted marginal resection. Statistical difference was found between the size of tumors with relatively wide resection and those with relatively marginal resection (F = 9.130, P = 0.005). No recurrence or metastasis occurred in patients who accepted wide resection, while 14 patients presented with local recurrence and 8 patients developed distant metastases among the 23 patients with marginal resection. Seven patients died of metastases, while one patient lived with metastases. No significant difference in survival was found between different surgical methods (X 2 = 0.9460, P = 0.3307). The average diameter of eight patients with distant metastases was 21.7 cm, which was considerable larger than the 12.1 cm of patients without metastasis. This difference was proven significant upon the statistical analysis (F = 9.412, P = 0.004).ConclusionsWide resection achieved good local control but was not unambiguously superior in long‐term survival. Myxoid liposarcoma tumors with larger diameters were more difficult to be submitted to wide resection and were more likely to present with distant metastasis.

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Section: Discussionmentioning

confidence: 99%

Surgical Outcomes and Prognostic Factors of Myxoid Liposarcoma in Extremities: A Retrospective Study

Zheng¹,

Yu²,

Xu³

et al. 2019

Orthopaedic Surgery

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“…A review of survival data from the literature indicates that several clinico-morphological factors such as tumour size, histologic subtype [2], and grading [2,3] or even selected molecular changes [4,5,6,7] may significantly affect disease-free or/and overall survival of LPS patients.…”

Section: Introductionmentioning

confidence: 99%

The role of histology, grading, location of tumour and ploidy in evaluation of outcome in patients with liposarcoma

Harazin-Lechowska¹,

Ambroziak-Lackowska²,

Ryś³

et al. 2017

pjp

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The review of literature indicates that several clinico-morphological factors such as location of the primary tumour as well as its size, histologic subtype, and grade or even selected molecular changes may significantly affect survival of liposarcoma (LPS) patients. Data concerning prognostic importance of DNA ploidy status in LPS cells are extremely limited and results of flow cytometry (FCM) studies have never been compiled with the current classification of malignant adipocytic tumours. Based on evaluation of material from 54 liposarcomas which was available for both histological and FCM analysis, we distinguished four prognostic groups of patients. The best prognosis was noticed for diploid and grade G1 well-differentiated or myxoid liposarcomas localised on extremities. None of the patients with lipoma-like WDLPS and myxoid liposarcoma grade 1 metastasised, while metastases were observed among patients with dedifferentiated LPS (70% of 5-year MFS) and cellular myxoid or round cell liposarcoma (20% of 5-year MFS, only). The metastasis-free survival curves for the above mentioned groups of patients differed significantly (p = 0.00001)

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“…Even though its etiology is unknown, it is related to some genetic alterations in the MDM2, HMGA2, and CDK4 genes [33], which our patient did not have. Disease-specific 5-year overall survival (5yOS) is 44%; however, this is dependent on location, and some data show that patients with DDLS with limb lesions have a 5yOS > 90% [34].…”

Section: Discussionmentioning

confidence: 99%

Clear cell renal carcinoma synchronous with dedifferentiated liposarcoma: a case report and review of the literature

et al. 2020

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Background: Multiple primary malignant neoplasms are not frequent but are increasing in incidence. Some of them are associated with genetic syndromes such as von Hippel-Lindau syndrome and Li-Fraumeni syndrome. Dedifferentiated liposarcoma is one of the rarest soft tissue tumors, and clear cell renal carcinoma is the most frequent kidney cancer. The concomitant presence of these tumors is extremely rare; however, some cases have been reported, none of them presenting with liposarcoma of the limbs. We report an interesting case of a patient with synchronous multiple primary tumors presenting with a very rare liposarcoma associated with renal cell carcinoma (a very rare association). A review of the literature and a collection of similar cases published previously are also provided. Case presentation: We report a case of a 62-year-old Hispanic man who presented to our institution with a left thigh mass compatible with dedifferentiated liposarcoma synchronous with metastatic clear cell renal carcinoma. Multiple treatment lines were provided with no response, with a further metastatic transformation. Genetic analysis by liquid biopsy showed some mutations that were not susceptible to targeted therapy. At the time of this report, the patient is undergoing palliative care because his nonresponsive metastatic disease persists. Conclusions: We present the first reported case of clear cell renal carcinoma synchronous with dedifferentiated liposarcoma of a limb. The association between renal cell carcinoma and dedifferentiated liposarcoma is unusual, and there are few reports of this presentation in the literature. More research about these tumors along with genetic tests needs to be performed to seek a better understanding of the fundamental basis of this rare association.

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Prognostic factors and outcome of Liposarcoma patients: a retrospective evaluation over 15 years

Cited by 46 publications

References 20 publications

Surgical Outcomes and Prognostic Factors of Myxoid Liposarcoma in Extremities: A Retrospective Study

Surgical Outcomes and Prognostic Factors of Myxoid Liposarcoma in Extremities: A Retrospective Study

The role of histology, grading, location of tumour and ploidy in evaluation of outcome in patients with liposarcoma

Clear cell renal carcinoma synchronous with dedifferentiated liposarcoma: a case report and review of the literature

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