Prognostic Factors and Outcome Analysis of Submandibular Gland Cancer: A Clinical Audit

Long‐term outcomes and prognosis in submandibular gland malignant tumors: A multicenter study

“…It is noteworthy, however, that in most publications, 5‐year OS is in the 50% to 56% range; moreover, our data also confirm that the OS decrease between 5 and 10 years is generally about 12% to 14% . Not unexpectedly, OS was affected, on univariate analysis, by pT status, pN status, PNS, facial nerve palsy, and pain at presentation, thus confirming the results of previous studies in which high pT category (pT3–4), nodal involvement, and PNS were the factors associated with dismal prognosis . The same factors also clearly impacted DSS (5‐year DSS, 76.6%; 10‐year DSS, 72.1%) and RFS (5‐year RFS: 69.1%; 10‐year RFS: 62.4%), both in line with previously reported values (5‐year DSS: 61%–76%, 5‐year RFS: 57%) .…”

“…4,8 Not unexpectedly, OS was affected, on univariate analysis, by pT status, pN status, PNS, facial nerve palsy, and pain at presentation, thus confirming the results of previous studies in which high pT category (pT3-4), nodal involvement, and PNS were the factors associated with dismal prognosis. 4,9,14,18,19,22,25 The same factors also clearly impacted DSS (5-year DSS, 76.6%; 10-year DSS, 72.1%) and RFS (5-year RFS: 69.1%; 10-year RFS: 62.4%), both in line with previously reported values (5-year DSS: 61%-76%, 5-year RFS: 57%). 4,8,20 This is further reinforced by our multivariate analysis, underlining the independent impact of PNS and nodal involvement on most survival and recurrence outcomes (Figs.…”

Patterns of lymph node metastasis and their influence on outcomes in patients with submandibular gland carcinoma

“…Unlike tumors of the parotid gland, which have been extensively described, the behavior, treatment, and prognosis of patients with SMG neoplasms are still under investigation. Because of their overall rarity, relatively limited information is available on patient survival and the factors predicting survival, although several retrospective series have shown that patient age, tumor stage and grade, nodal involvement, and treatment are important prognostic factors for locoregional control and survival 1–9…”

“…Larger and more invasive primary tumors require the removal of the gland, along with supraomohyoid ND. Some patients, especially those with metastatic lymphadenopathy, may require a more comprehensive ND, such as modified radical ND or occasional radical ND 3, 10. No other studies, however, have assessed the metastatic topography of SMG carcinoma.…”

Examined and positive lymph nodes counts and lymph nodes ratio are associated with survival in major salivary gland cancer

“…They investigated the prognostic role of many factors including age, sex, tumor size, and facial nerve involvement . As prognostic markers are of a pivotal role for an improved diagnosis and treatment of these tumors, several studies were conducted to explore the significance of clinical and histological biomarkers such as the nodal count on the prediction of survival in patients with cancer . In 2013, Jayaprakash et al found that lymph nodes (LNs) involvement had a significant predictive value .…”