Prognostic Factors and Long-Term Survival in Endometrial Adenocarcinoma with Cervical Involvement

Boente, Matthew P.; Yordan, Edgardo; McIntosh, David G.; Grendys, Edward C.; Orandi, Yasmin A.; Davies, S. J.; Beck, David B.; Graham, James E.; Miller, Alexander W.; Marshall, Roland; Dolan, Thomas F.; Kirschner, Caroline; Reddy, Salitha; Wilbanks, George D.

doi:10.1006/gyno.1993.1297

Cited by 84 publications

(62 citation statements)

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“…The ages of the patients ranged from 38 to 74 years, with a mean of 57. 4 Diagnosing Endometrial Carcinoma cervical involvement than in those without. Figure 3 showed smears of cases with and without cervical involvement.…”

Section: Resultsmentioning

confidence: 97%

“…The presence of cervical involvement correlates more with a high risk of extrauterine diseases 4,16 and poor survival than does the absence of cervical involvement. 11 In FIGO staging, the prognosis of patients with stage II cancer involving the cervix is worse than that of patients with stage I cancer, limited to the uterine corpus.…”

Section: Objective: To Assess the Relationship Of A Cervical Cytologimentioning

confidence: 99%

“…8,10,14,18 Several authors recommend radical hysterectomy, which carries a better survival rate for patients with cervical involvement than does that for patients who undergo simple hysterectomy. 4,6,8,14 Radical hysterectomy is performed on patients with cervical involvement at many institutions. However, radical hysterectomy carries appreciable morbidity, definitely greater than that of less radical hysterectomy.…”

Section: Objective: To Assess the Relationship Of A Cervical Cytologimentioning

confidence: 99%

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Diagnosing Endometrial Carcinoma with Cervical Involvement by Cervical Cytology

et al. 2002

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Section: Resultsmentioning

confidence: 97%

Section: Objective: To Assess the Relationship Of A Cervical Cytologimentioning

confidence: 99%

Section: Objective: To Assess the Relationship Of A Cervical Cytologimentioning

confidence: 99%

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Diagnosing Endometrial Carcinoma with Cervical Involvement by Cervical Cytology

et al. 2002

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“…Metastasis to lymph nodes is among the proven prognostic factors in EC which occurs in around 10% of patients with stage I disease and around 20% of patients with stages II and IIIA-B 5,22 . This is the rationale behind recommending pelvic and para-aortic lymphadenectomy during surgical staging in addition to total abdominal hysterectomy plus bilateral salpingooophorectomy 5,22,23 . Because of the significant morbidity that may complicate lymphadenctomies, we conducted this study to assess the capability of a perioperative SLN algorithm for reduction of pelvic lymphadenectomy.…”

Section: Discussionmentioning

confidence: 99%

Perioperative Algorithm as a Novel Method for Lymph Node Assessment in Stage I Endometrial Cancer

Atta

Hegab

El-Ashkar

et al. 2018

Kasr-Al-Aini J.of Clin. Onc. and Nuc. Med.

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Background:The uterus has a complex lymphatic drainage consisting of many groups that are in danger of endometrial cancer (EC) spread. Lymph node metastasis is a genuine pointer of poor prognosis requiring adjuvant therapy. Lymphatic mapping surgically can be done by blue dye labeling and perioperative algorithm. Aim: To assess the role of perioperative sentinel lymph nodes (SLN) mapping algorithm in reducing the necessity of pelvic lymphadenectomy. Methods: Fifty patients with early stage I EC underwent surgical staging. Transcervical injection of methylene blue was used, laparotomy was done and retroperitoneal spaces were opened. All lymph nodes were histopathologically examined and the negative SLN were ultrastaged. Results: Methylene blue dye injection resulted in blue lymph nodes in 20 (40%) cases, suspicious in 2 (4%) and negative in 28 (56%). Histopathological examination of sampled lymph node showed metastases in 18/20 (90%) of blue nodes, 1/2 (50%) of suspicious nodes and 0/28 (0%) of negative nodes. There were no false negative cases in this study and the detection rate was 89%. Conclusion: Perioperative algorithm accuracy and simplicity make it a reliable approach for lymph node assessment in early stage EC.

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“…12 Additionally, Boente et al showed an increased difference in survival with RH in case there is gross cervical involvement. 13 Nevertheless, others suggested that SH instead of RH may be a sufficient treatment for the patients with clinical cervical involvement, while others recommended the same for only the patients with microscopic cervical involvement.…”

Section: Recurrencementioning

confidence: 99%

Analysis of Patients with 1988 FIGO Stage-II Endometrial Cancer

Üreyen¹

2014

UHOD

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Management of stage II endometrial cancer still has many controversies. We evaluated patients with stage II (FIGO 1988) endometrial cancer operated in our clinic in terms of treatment modalities, surgico-pathological factors, recurrence rates and patterns. Fifty-three patients with 1988 FIGO stage II endometrial cancer who underwent staging surgery between January 1993 and December 2012 were included in this study. The mean age of the patients was 57 years. Cervical invasion couldn't be detected in the preoperative pelvic examination in 47 patients (88.7%). Thirty-eight patients received simple hysterectomy (SH) and 15 patients had radical hysterectomy (RH). All patients received pelvic and paraaortic lymphadenectomy. Forty-two patients took adjuvant radiotherapy. The median follow-up time of the patient population was 39 months (range 1-139 months). Recurrence was observed in four patients. There was no statistically significant difference between the RH and SH groups in terms of recurrence (p= 0.53). Advanced age, deep myometrial invasion and the lower number of harvested lymph nodes were associated with recurrence. Systemic adjuvant therapy may be involved in the first-line treatment plan in order to prevent distant failures, since they continue to be responsible for the most of the recurrences and mortality despite radical surgeries and different protocols of adjuvant radiotherapy. Keywords: Endometrial cancer, Cervical invasion, Survival, Lymphadenectomy ÖZET FIGO Evrelemeseni Göre Evre II Endometrium Kanseri Olan Hastaların AnaliziEvre II endometriyum kanserinin yönetimi hala tartışmalıdır. Kliniğimizde opere olan evre II endometriyum kanseri olan hastaları tedavi çeşitleri, cerrahi-patolojik faktörler, rekürrens şekli ve sıklığı açısından değerlendirdik. Çalışmaya Ocak 1993 ve Ekim 2012 tarihleri arasında evreleme cerrahisi geçiren evre II endometriyum kanseri olan 53 hasta dahil edildi. Hastaların ortalama yaşı 57 idi. Servikal invazyon 47 hastanın (%88.7) preoperatif incelemesinde saptanamadı. Otuz-sekiz hastaya basit histerektomi (BH) ve 15 hastaya radikal histerektomi (RH) yapıldı. Tüm hastalara pelvik ve paraaortik lenfadenektomi yapıldı. Kırk-iki hasta adjuvan radyoterapi aldı. Hastaların ortalama takip süresi 39 aydı (aralık, 1-139). Rekürrens 4 hastada gelişti. RH ve BH grupları arasında rekürrens açısından farklılık yoktu (p= 0.53). İleri yaş, derin myometrial invazyon ve az sayıda lenf nodu çıkartılması rekürrens ile ilişkiliydi. Evre II endometriyum kanserinde radikal cerrahilere ve farklı adjuvan radyoterapi protokollerine rağmen rekürrenslerin ve mortalitenin esas sorumlusu uzak metastazlardır. Bundan dolayı, uzak metastazları engelleyebilmek için sistemik adjuvan tedavi bu hastalığın birinci basamak tedavisinde düşünülebilir.Anahtar Kelimeler: Endometriyum kanseri, Servikal invazyon, Sağkalım, Lenfadenektomi 240UHOD

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Prognostic Factors and Long-Term Survival in Endometrial Adenocarcinoma with Cervical Involvement

Cited by 84 publications

References 0 publications

Diagnosing Endometrial Carcinoma with Cervical Involvement by Cervical Cytology

Diagnosing Endometrial Carcinoma with Cervical Involvement by Cervical Cytology

Perioperative Algorithm as a Novel Method for Lymph Node Assessment in Stage I Endometrial Cancer

Analysis of Patients with 1988 FIGO Stage-II Endometrial Cancer

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Prognostic Factors and Long-Term Survival in Endometrial Adenocarcinoma with Cervical Involvement

Cited by 84 publications

References 0 publications

Diagnosing Endometrial Carcinoma with Cervical Involvement by Cervical Cytology

Diagnosing Endometrial Carcinoma with Cervical Involvement by Cervical Cytology

Perioperative Algorithm as a Novel Method for Lymph Node Assessment in Stage I Endometrial Cancer

Analysis of Patients with 1988 FIGO Stage-II Endometrial Cancer

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Analysis of Patients with 1988 FIGO Stage-II Endometrial Cancer