Prognostic Factors and Antibiotics in Vibrio vulnificus Septicemia

Abstract

Septic shock is a determinant of fatality in patients with V vulnificus septicemia without HBNCLs; our data suggest that the combination of a third-generation cephalosporin and tetracycline or its analogue may be a better choice in antimicrobial treatment of V vulnificus septicemic patients with HBNCLs.

Evaluation of the Bruker Biotyper Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry System for Identification of Blood Isolates of Vibrio Species

“…Vibrio cholerae and non-cholerae Vibrio species, especially V. vulnificus, V. parahaemolyticus, V. fluvialis, and V. alginolyticus, have been reported to also cause severe gastroenteritis, severe skin soft tissue infection (necrotizing fasciitis), biliary tract infections, septicemia, and other serious infections in immunocompromised and immunocompetent hosts (2)(3)(4)(5)(6)(7)(8)(9). Given the potential of V. cholerae for rapid epidemic spread and its listing as a biothreat level B agent, it is crucial for clinical microbiology laboratories to be able to correctly identify and differentiate V. cholerae from other bacterial species, particularly Aeromonas species (10).…”

Seasonality, clinical types and prognostic factors of Vibrio vulnificus infection

“…Human infections due to V. vulnificus, initially described by Blake et al [7], are uncommon but potentially life-threatening. The reported incidence and case-fatality rates of V. vulnificus infections are approximately 0.001 to 1.237 per million people and 10% to 54% over the past three decades, respectively [2][3][4][5][6][8][9][10][11][12]. V. vulnificus infections can be transmitted by eating contaminated or raw seafood or by exposure to seawater through a skin wound.…”

“…The infection exhibits two main clinical manifestations, including primary septicemia and primary wound infections, which can progress rapidly and become lethal even to an otherwise healthy person; therefore, promptly ascertaining this infection and instantly recognizing the risk factors present in these patients appears to be crucial. Most reports have focused on V. vulnificus infections with primary septicemia in highrisk persons who have underlying immunocompromised conditions and have consumed raw or undercooked seafood or shellfish, especially oysters [2][3][4][5][6][7][8][9][10][11][12]. With the increment in marine activities, the reported number of V. vulnificusinfected cases due to wound infection has been increasing over recent years [11,13].…”

In Vitro Activities of Tigecycline against Clinical Isolates of Aeromonas , Vibrio , and Salmonella Species in Taiwan

“…Wound infection and bacteremia caused by V. vulnificus are associated with mortality rates as high as 55% (4, 9). Strains of Aeromonas species could also cause fatal soft tissue infection in immunocompromised hosts and especially in cirrhotic patients (10,11,14). Traditionally, cefotaxime, ceftriaxone, and fluoroquinolones were active against V. parahaemolyticus and V. vulnificus infection (14).…”

“…Strains of Aeromonas species could also cause fatal soft tissue infection in immunocompromised hosts and especially in cirrhotic patients (10,11,14). Traditionally, cefotaxime, ceftriaxone, and fluoroquinolones were active against V. parahaemolyticus and V. vulnificus infection (14). However, emerging resistance among Aeromonas and Salmonella species has been reported recently (15).…”