Prognostic factors affecting survival in metastatic soft tissue sarcoma: an analysis of 110 patients

Abstract

Serum albumin, tumor size, hemoglobin and treatment modality affect survival in metastatic STS.

Serum creatinine and albumin predict sarcoma‐specific survival in patients with myofibroblastic and fibroblastic sarcomas

“…Iqubal et al evaluated putative prognostic factors in metastatic STS and showed that low serum albumin (<4 g/dl) is significantly associated with a poor event‐free survival (EFS) in uni‐ and multivariate analysis. Their patient collective included 110 patients with different types of STS . In line with these findings, the present study showed a significantly lower recurrence‐free survival in sarcoma patients with low serum albumin values.…”

“…Their patient collective included 110 patients with different types of STS. 49 In line with these findings, the present study showed a significantly lower recurrence-free survival in sarcoma patients with low serum albumin values. Panotopoulos and co-workers analyzed 84 patients affected by liposarcoma and proved poorer overall and disease-specific survival in patients with presurgical values of albumin under 35 g/L.…”

“…Serum albumin has been described as an independent prognosticator of survival in various cancers entities like lung, pancreatic, gastric, colorectal, hepatocellular, gastric, ovarian, breast cancer, and multiple myeloma . For the tumor entity of sarcomas hypoalbuminemia proved as independent prognostic marker for survival in Ewing sarcomas and soft tissue sarcomas . Iqubal et al evaluated putative prognostic factors in metastatic STS and showed that low serum albumin (<4 g/dl) is significantly associated with a poor event‐free survival (EFS) in uni‐ and multivariate analysis.…”

“…23,31,48 For the tumor entity of sarcomas hypoalbuminemia proved as independent prognostic marker for survival in Ewing sarcomas 25 and soft tissue sarcomas. 24,32,49 Iqubal et al evaluated putative prognostic factors in metastatic STS and showed that low serum albumin (<4 g/dl) is significantly associated with a poor event-free survival (EFS) in uni-and multivariate analysis. Their patient collective included 110 patients with different types of STS.…”

Prognostic relevance of distant metastases versus locally advanced disease in soft tissue sarcomas: An EORTC-STBSG database study

“…This was also found recently in an Indian study which showed that patients with extremity tumours and patients with multimodality treatment had a favourable prognosis, suggesting that the possibility of aggressive treatment of the primary tumour localization may result in a better survival. (26) Tumour site is also a known prognostic factor in surgically treated non-metastatic sarcoma patients. (27) Time since initial diagnosis behaves differently as prognostic factor between patients with LAD (both a very short time and a very long time from initial diagnosis were associated with a favourable prognosis) and both the other groups (only a long time interval from initial diagnosis having a favourable diagnosis).…”