Prognostic evaluation of the elastic properties of the ascending aorta in dilated cardiomyopathy

Sciatti, Edoardo; Vizzardi, Enrico; Bonadei, Ivano; Fabbricatore, Davide; Prati, Francesco; Pagnoni, Mattia; Metra, Marco

doi:10.1111/eci.12950

Cited by 5 publications

(6 citation statements)

References 28 publications

(54 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have evaluated the impairment in ascending aortic elastic properties in different diseases using different techniques to analyze the above elastic parameters. 13 –18 Although many studies 19,20 analyzed the prevalence of aortic stiffness in either hypertensive and diabetic patients, only few were conducted to investigate whether essential hypertension (EH) or type 2 diabetes mellitus (T2DM) had a greater effect on aortic stiffness in patients with T2DM + EH.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Effect of Essential Hypertension on Elasticity of Ascending Aorta in Type 2 Diabetic Mellitus Patients by Echocardiography

et al. 2020

View full text Add to dashboard Cite

Both essential hypertension (EH) and type 2 diabetes mellitus (T2DM) can impair the elasticity of the ascending aorta. We prospectively enrolled 42 patients with T2DM, 44 patients with EH, 45 patients with T2DM and EH (T2DM + EH), and 41 healthy subjects (HS). They all underwent transthoracic echocardiography to measure ascending aorta inner diameters and a brachial blood pressure measurement to calculate aortic elastic parameters (ie, compliance, distensibility, strain, stiffness index, and Peterson elastic modulus). We found that there were no significant differences as regard with age, sex, body mass index, blood lipids and glucose, carotid atherosclerosis, and ascending aorta inner diameters among the 4 groups. The aortic elastic properties were significantly impaired in T2DM, EH, and T2DM + EH patients compared with the HS, and more impaired in EH and T2DM + EH patients than T2DM patients; there were no significant differences between EH and T2DM + EH patients. Our findings suggest that both T2DM and EH can impair aortic elastic properties. Essential hypertension may play a more important role in the process of ascending aorta sclerosis in patients with T2DM + EH.

show abstract

Section: Introductionmentioning

confidence: 99%

Evaluation of the Effect of Essential Hypertension on Elasticity of Ascending Aorta in Type 2 Diabetic Mellitus Patients by Echocardiography

et al. 2020

View full text Add to dashboard Cite

show abstract

“…19 However, the echocardiographic assessment of early atherosclerosis via ascending aorta elasticity in JDM remains unexplored. [20][21][22] Our study aimed to assess aortic elasticity variables in JDM patients using echocardiography. Notably, we observed lower elasticity and aortic strain in JDM patients compared to controls, suggesting incipient aortic atherosclerosis even in the absence of aortic diameter enlargement.…”

Section: Discussionmentioning

confidence: 99%

Exploring cardiovascular implications of juvenile dermatomyositis: Insights from aortic stiffness analysis and 3D echocardiography

Dedeoglu,

Uluğ Murt,

Gunalp

et al. 2024

Echocardiography

View full text Add to dashboard Cite

ObjectiveOur goal was to use three dimensional (3D) strain analysis to evaluate myocardial function and ascending aorta elasticity changes in juvenile dermatomyositis (JDM).MethodsBetween 2019 and 2021, 23 JDM patients and 20 healthy volunteers participated. Both groups underwent 2D and 3D strain analysis, assessing aortic stiffness using aortic distensibility, stiffness index, strain, and elastic modulus.ResultsJDM patients had a median age of 13.3 ± 5.2 years, while controls had a median age of 13.8 ± 4.76 years. 3D strain analysis revealed significantly lower global longitudinal (GLS) and circumferential strain (GCS) in JDM patients compared to controls. Specifically, 3D GLS was notably reduced in patients (−28.1% vs. −31%, p = .047) compared to controls, and 3D GCS was also lower in patients (−27.5% vs. −30.5%, p = .019) compared to controls. Aortic strain and elastic modulus were significantly lower in JDM patients, while aortic stiffness index and distensibility showed no significant differences. Correlation analyses within the JDM group revealed a negative correlation between 3D GLS and age at diagnosis (r = −.561, p = .04), as well as a positive correlation between 3D GLS and both aortic strain (r = .514, p = .0001) and elastic modulus (r = .320, p = .03) in JDM patients.ConclusionOur study demonstrated a trend towards lower ejection fraction and strain in patients with JDM, along with increased aortic stiffness using 3D echocardiography. These findings suggest potential cardiovascular involvement in juvenile dermatomyositis, emphasizing the importance of comprehensive cardiac assessments in these patients.

show abstract

“…In the heart, venous and ventricular compliance are both key parameters in the determination of cardiac function [ 22 , 23 ]. Stiffer aortas are associated with heart failure-associated rehospitalization in patients with dilated cardiomyopathy [ 24 ]. In vivo introduction of bioengineered tissues with inappropriate bulk mechanical properties will unfortunately be accompanied by introduction of clinical symptoms.…”

Section: Ecm Mechanics At Different Scalesmentioning

confidence: 99%

Accounting for Material Changes in Decellularized Tissue with Underutilized Methodologies

Hansen

Wang

Kaw

et al. 2021

BioMed Research International

View full text Add to dashboard Cite

Tissue decellularization has rapidly developed to be a practical approach in tissue engineering research; biological tissue is cleared of cells resulting in a protein-rich husk as a natural scaffold for growing transplanted cells as a donor organ therapy. Minimally processed, acellular extracellular matrix reproduces natural interactions with cells in vitro and for tissue engineering applications in animal models. There are many decellularization techniques that achieve preservation of molecular profile (proteins and sugars), microstructure features such as organization of ECM layers (interstitial matrix and basement membrane) and organ level macrofeatures (vasculature and tissue compartments). While structural and molecular cues receive attention, mechanical and material properties of decellularized tissues are not often discussed. The effects of decellularization on an organ depend on the tissue properties, clearing mechanism, chemical interactions, solubility, temperature, and treatment duration. Physical characterization by a few labs including work from the authors provides evidence that decellularization protocols should be tailored to specific research questions. Physical characterization beyond histology and immunohistochemistry of the decellularized matrix (dECM) extends evaluation of retained functional features of the original tissue. We direct our attention to current technologies that can be employed for structure function analysis of dECM using underutilized tools such as atomic force microscopy (AFM), cryogenic electron microscopy (cryo-EM), dynamic mechanical analysis (DMA), Fourier-transform infrared spectroscopy (FTIR), mass spectrometry, and rheometry. Structural imaging and mechanical functional testing combined with high-throughput molecular analyses opens a new approach for a deeper appreciation of how cellular behavior is influenced by the isolated microenvironment (specifically dECM). Additionally, the impact of these features with different decellularization techniques and generation of synthetic material scaffolds with desired attributes are informed. Ultimately, this mechanical profiling provides a new dimension to our understanding of decellularized matrix and its role in new applications.

show abstract

Prognostic evaluation of the elastic properties of the ascending aorta in dilated cardiomyopathy

Abstract: Elastic properties of the ascending aorta measured by echocardiography in patients with nonischaemic DCM predict long-term HF rehospitalization and combined death or HF rehospitalization, also after correcting for the confounding factors.

Cited by 5 publications

References 28 publications

Evaluation of the Effect of Essential Hypertension on Elasticity of Ascending Aorta in Type 2 Diabetic Mellitus Patients by Echocardiography

Evaluation of the Effect of Essential Hypertension on Elasticity of Ascending Aorta in Type 2 Diabetic Mellitus Patients by Echocardiography

Exploring cardiovascular implications of juvenile dermatomyositis: Insights from aortic stiffness analysis and 3D echocardiography

Accounting for Material Changes in Decellularized Tissue with Underutilized Methodologies

Contact Info

Product

Resources

About