Prognostic evaluation of resectable colorectal cancer using platelet‑associated indicators

Qian, Weihua; Ge, Xin-Xin; Wu, Jing; Gong, Fei‐Ran; Wu, Mengyao; Xu, Mengdan; Lian, Lian; Wang, Wenjie; Li, Wei; Tao, Min

doi:10.3892/ol.2019.10388

Cited by 22 publications

(29 citation statements)

References 39 publications

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“…CRC studies with PLT, PDW, MPV and other platelet-related indicators as the study objects had emerged one after another in recent years [10,55] . Platelets not only produce the blood clotting cascade, but also regulate inflammatory response and cancer pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

“…Blood routine test (BRT), as one of the most basic peripheral blood biochemical tests, can quickly and accurately detect the values of blood components such as white blood cells (WBC), lymphocytes (LY), red blood cells (RBC), hemoglobin (HGB) and platelets (PLT), as well as other related indicators, in order to effectively indicate abnormalities of infection, anemia and cruor [7][8][9] . In recent years, a wide variety of blood indicators with different changes were concerned and discussed in the study of malignant tumor diseases including CRC: Qian W, et al reported that the post-/pre-treatment MPV (Mean Platelet Volume) ratio were prognostic factors for OS in resectable CRCs [10] ; Preoperative neutrophil-lymphocyte ratio (NLR) and red blood cell distribution width (RDW), especially the independent prediction of NLR, were confirmed as effective biomarkers for clinical diagnosis and prognosis evaluation of esophageal cancers [11] ; In patients with pathologic stage I non-small cell lung cancer undergoing surgical resection, high LY and PLT count from peripheral blood could provide poor prognostic value independently [12] ; Even the ratios between indicators were developed into new indexes, which had fairly good prognostic significance, including NLR, Platelet-to-Lymphocyte Ratio (PLR), Lymphocyte-to-Monocyte ratio (LMR). [13][14][15][16] .…”

Section: Ivyspringmentioning

confidence: 99%

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Prognostic evaluation of colorectal cancer using three new comprehensive indexes related to infection, anemia and coagulation derived from peripheral blood

Li¹,

Wu²,

Xing³

et al. 2020

J. Cancer

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Background: Many indicators of peripheral blood in routine blood test (BRT) results of colorectal cancer (CRC) patients are related to prognosis. Currently, indexes such as NLR (Neutrophil-to-Lymphocyte Ratio), PLR (Platelet-to-Lymphocyte Ratio) and LMR (Lymphocyte-to-Monocyte ratio) evaluate the survival risk of patients by assessing the inflammatory-immune status of CRCs. These indexes are more comprehensive and accurate than independent estimates. We hope to design more effective indexes through fully considering the correlation and significance between BRT indicators and prognosis, so as to play a guiding role in clinical malignant estimation of CRCs. Methods: 701 CRCs in training set and 256 CRCs in test set were included in the study samples, and their clinical data, tumor pathology results and peripheral blood routine results were collected. The prognosis, progression, and survival status of all patients were determined after follow-up. Above data were used for statistical analysis and designing new indexes. Results: It was found that high NE, MONO, RDW-CV/SD and PLT in peripheral blood indicated poor prognosis of DFS and OS. Conversely, CRCs with postoperative tumor progression or death had lower LY, EO, RBC, HGB, HCT, MCV, MCH, MCHC, PDW, and P-LCR. IRR, ARR and CRR related to infection, anemia and coagulation were designed respectively using the largest AUC indicators (P<0.05) selected by ROC curve. The formula: IRR= (NE*MONO)/(LY*EO); ARR= (HGB*MCHC)/RDW-CV; CRR=PLT/PDW. Results of Kaplan-Meier survival analysis and multivariate COX proportional hazard analysis adjusted for age, gender, TNM stage, infiltration, adhesion showed IRR, ARR, CRR were all able to be used as the evaluation standard of survival of CRC. The result was also authenticated in the test set. Conclusion: We designed three different prognostic indexes of colorectal cancer, IRR, ARR and CRR, which could be used as risk indicators of CRC prognosis, tumor progression and survival.

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Section: Discussionmentioning

confidence: 99%

Section: Ivyspringmentioning

confidence: 99%

Prognostic evaluation of colorectal cancer using three new comprehensive indexes related to infection, anemia and coagulation derived from peripheral blood

Li¹,

Wu²,

Xing³

et al. 2020

J. Cancer

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“…Thrombocytosis was reported to have a prognostic role both prior to and after primary tumor removal [16][17][18][19]. Furthermore, studies on CRC and other platelet-related indicators and ratios like mean platelet volume (MPV), the mean platelet volume-platelet count ratio (MPV/PC) and the platelet -lymphocyte ratio (PLR) were conducted recently [19,46,47]. Compared to the healthy controls, CRC patients had significantly lower MPV/PC and significantly higher PLR values [46].…”

Section: Discussionmentioning

confidence: 99%

Personalized Indicator Thrombocytosis Shows Connection to Staging and Indicates Shorter Survival in Colorectal Cancer Patients with or without Type 2 Diabetes

Herold

Lohinszky

et al. 2020

Cancers

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Background: Pre- and postoperative thrombocytosis was reported to have significant effect on patient survival. However, the definition of thrombocytosis throughout the literature is not unified. Methods: A retrospective longitudinal observational study has been conducted with the inclusion of 150 colorectal cancer (CRC) patients and 100 control subjects. A new measure of platelet changes at an individual level, named personalized indicator thrombocytosis (PIT) was defined, including 4 anemia adjusted variants. Results: In concordance with the literature, PIT values of control subjects showed a slow decrease in platelet counts, while PIT values of CRC patients were significantly higher (p < 0.0001). More advanced staging (p < 0.0001) and both local (p ≤ 0.0094) and distant (p ≤ 0.0440) metastasis are associated with higher PIT values. Higher PIT values suggested shorter survival times (p < 0.0001). Compared to conventional, a PIT-based definition resulted in approximately 3-times more patients with thrombocytosis. 28% and 77% of the deceased patients had conventional- and PIT-based thrombocytosis, respectively. Conclusions: Compared to conventional thrombocytosis, as an individual metric, PIT values may indicate the condition of patients more precisely. Possible future applications of PIT may include its usage in therapy decision and early cancer detection; therefore, further investigations are recommended.

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“…Platelets-associated indicators and platelet counts have been shown associated with the prognosis of resectable lung and colorectal cancers [37][38][39]. In addition to the predictive role of platelets-associated indicators in cancer, platelet counts, or protein markers, Best et.…”

Section: Discussionmentioning

confidence: 99%

Identification of Potential Tumor-educated Platelets RNA Biomarkers for Pan Cancer Detection and Staging

Ge¹,

Yuan²,

Hu³

et al. 2020

Preprint

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Cancer is a disturbing disease with high morbidity and mortality. Although medical technology has been developed rapidly, diagnosis of cancer is still complicated, difficult, as well as expensive. Furthermore, cancers are mostly diagnosed at an advanced stage. Platelets mRNA profiles are altered after educated by tumors. Thereby, tumor-educated platelets (TEPs) mRNA profiles have the potentially diagnostic value for cancers currently. We downloaded and analyzed the next-generation sequencing datasets, GSE68086 and GSE89843, by integrated bioinformatics. A total of 43 biomarker genes were selected for further pathway enrichment analysis and correlation analysis, as well as diagnostic analysis. Gene ontology (GO) analysis showed these 43 TEPs mRNAs were mostly involved in protein binding, extracellular matrix and cellular protein metabolic process. Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis revealed that genes were mainly enriched in metabolic process. Eventually, after taking these 43 genes into spearman correlation analysis and receiving operating characteristic (ROC) curve analysis, we identified: 1) TEPs RSL24D1 mRNA was negatively related to early pan cancer as compared to healthy controls, and potential for early pan cancer diagnosis with a sensitivity of 71.8%, and a specificity of 64.3%; 2) HPSE, IFI27, LGALS3BP, CRYM, HBD, COL6A3, LAMB2, and IFITM3 showed an upward trend in the expression from early to more advanced pan cancer stages. The sensitivity of the diagnostic value for pan cancer of these genes was 60.9%, 59.1%, 56.5%, 57.8%, 54.3%, 55.2%, 55.2%, 60.9%, and a specificity of 94.5%, 90.9%, 87.3%, 89.1%, 72.7%, 85.5%, 89.1%, 94.5% respectively; 3) ARL2, FCGR2A, and KLHDC8B were positively associated with advanced, metastatic pan cancer as compared to healthy controls and could be diagnostic indicators for advanced pan cancer with a sensitivity of 59.2%, 61.8%, 59.7%, and a specificity of 80%, 89.1%, 83.6%, respectively. In summary, our findings identified that the 12-gene TEP liquid-biopsy biomarkers will not only facilitate early diagnosis of pan cancer, but also be beneficial to pan cancer staging.

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Prognostic evaluation of resectable colorectal cancer using platelet‑associated indicators

Cited by 22 publications

References 39 publications

Prognostic evaluation of colorectal cancer using three new comprehensive indexes related to infection, anemia and coagulation derived from peripheral blood

Prognostic evaluation of colorectal cancer using three new comprehensive indexes related to infection, anemia and coagulation derived from peripheral blood

Personalized Indicator Thrombocytosis Shows Connection to Staging and Indicates Shorter Survival in Colorectal Cancer Patients with or without Type 2 Diabetes

Identification of Potential Tumor-educated Platelets RNA Biomarkers for Pan Cancer Detection and Staging

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