Prognostic efficacy of C-reactive protein/albumin ratio in ST elevation myocardial infarction

Çınar, Tufan; Çağdaş, Metin; Rencüzoğulları, İbrahim; Karakoyun, Süleyman; Karabağ, Yavuz; Yesi̇n, Mahmut; Çağdaş, Öznur Sadioğlu; Tanboğa, Halil İbrahim

doi:10.1080/14017431.2019.1590628

Cited by 81 publications

(59 citation statements)

References 28 publications

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“…25,26 CRP/albumin ratio was also found to be a potentially useful prognostic marker for predicting a poor prognosis in ST elevation myocardial infarction patients. 27 Based on the ROC curve results, cutoff values of ! 25.83 for the CRP/albumin ratio were found to be significantly predictive of mortality with 85.4% accuracy.…”

Section: Discussionmentioning

confidence: 99%

C-Reactive Protein/Albumin Ratio as an Independent Predictor of Mortality in Critically Ill Pediatric Patients

Mohamed

Hawary

2020

Journal of Child Science

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It is necessary to stratify the risk of pediatric patients at the time of intensive care unit (ICU) admission and to predict their outcomes. This helps to allocate the scarce ICU resources to start the appropriate treatment. The objective of this study was to evaluate the prognostic value of C-reactive protein/albumin ratio on admission to pediatric intensive care unit (PICU) in predicting mortality, PICU length of stay, the need for mechanical ventilation, and the use of inotropic drugs. This cohort study was conducted at Pediatric Cairo University Hospital. The study included 178 critically ill children. Pediatric Risk of Mortality–III (PRISM-III) score was calculated; CRP and serum albumin levels were assessed within 24 hours from admission. The median CRP/albumin ratio was significantly higher in nonsurvivors than survivors (18.60 and 4.65, respectively). The CRP/albumin ratio at a cutoff of ≥25.83 had significant discriminatory power in predicting mortality (area under the curve [AUC] = 0.795 and p < 0.001) with 85.4% accuracy. Furthermore, CRP/albumin ratio alone showed a comparable discriminatory power to that of PRISM-III score (AUCs = 0.795 and 0.793, respectively). A multivariable logistic regression analysis revealed that each unit of increase in the CRP/albumin ratio increased the risk of mortality by 1.075 (odds ratio [OR] = 1.075). CRP/albumin ratio showed a significantly higher median in ventilated (6.86) compared with non-ventilated (5.22) patients. Patients supported with inotropes showed significantly higher median CRP/albumin ratio (11.70 and 3.68, respectively). CRP/albumin ratio at admission to PICU was a good independent predictor of mortality.

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Section: Discussionmentioning

confidence: 99%

C-Reactive Protein/Albumin Ratio as an Independent Predictor of Mortality in Critically Ill Pediatric Patients

Mohamed

Hawary

2020

Journal of Child Science

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“…Although preprocedural NLR is higher in patients with delirium, contrary to Egberts and Mattace-Raso (24), we have not observed any relationship between NLR and delirium. Furthermore, some previous studies have suggested that CAR was superior to NLR in predicting systemic inflammation and prognosis in several cardiac and noncardiac conditions (36,37).…”

Section: Discussionmentioning

confidence: 99%

C-reactive Protein to Albumin Ratio as A Novel Inflammatory Biomarker for Postoperative Delirium in Patients Undergoing Transcatheter Aortic Valve Replacement

Kalyoncuoğlu¹,

Biter²,

Durmuş³

et al. 2020

Haseki

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We aimed to investigate whether C-reactive protein-toalbumin ratio (CAR) predicts postoperative delirium (POD) development in patients undergoing transcatheter aortic valve replacement (TAVR) procedure. Methods: Data of 78 patients with the mean age of 76.3±8.4 years, who underwent TAVR, were retrospectively analyzed. The CAR, neurophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio values were calculated in all patients. Presence of delirium was determined by using the Richmond Agitation-sedation scale and the Confusion Assessment Method for the Intensive Care Unit. Results: As compared with the nondelirious group, delirious patients had significantly higher EuroSCORE II (p=0.03) and TAVR score (p=0.009) and more frequent major bleeding (p=0.005), major vascular complications (p=0.018) and acute kidney injury (AKI) (p=0.002). The main independent predictors of POD were CAR value (p=0.02), AKI (p=0.02), major bleeding (p=0.005), and TAVR score (p=0.04). The area under the curve of CAR for POD development was 0.718 (95% confidence interval: 0.605-0.814; p=0.002) with 82% sensitivity and 56% specificity. Conclusion: CAR is a promising inflammatory parameter in predicting POD and may help identify subgroups of individuals at risk for POD.

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“…In recent years, CAR has attracted much attention as a novel predictor of coronary artery disease severity and prognosis [10][11][12]18]. We hypothesized that CAR might have prognostic value for predicting the prognosis of patients with SCAD.…”

Section: Subgroup Analysesmentioning

confidence: 99%

“…Therefore, both in ammatory cytokines and Alb can be used to predict the prognosis of cardiovascular disease, but is there a better index to replace both CRP and Alb? A new in ammatory indicator: the CRP to Alb ratio (CAR), was found to aid in the assessment of acute coronary syndrome severity, coronary ow status, and could predict the prognostic outcome in ST-elevation myocardial infarction patients, which can better re ect the body's in ammatory status [10][11][12]. However, the prognostic value of CAR in patients with SCAD is unclear.…”

Section: Introductionmentioning

confidence: 99%

The C-reactive protein to albumin ratio is a novel prognostic factor in patients with stable coronary artery disease following percutaneous coronary intervention

Zou¹,

Zhong²,

Zeng³

et al. 2020

Preprint

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Background Previous studies have shown that both C-reactive protein (CRP) and albumin (Alb) are the prognostic factors of cardiovascular. However, the prognostic value of C-reactive protein to albumin ratio (CAR) in patients with stable coronary artery disease (SCAD) is unclear. Methods This was a retrospective cohort study that continuously enrolled 204 patients with newly diagnosed SCAD between October 2014 and October 2017; the mean follow-up time was 793.75 ± 430.26 days. The Cox proportional hazard model was used to evaluate the prognostic value of CAR in patients with SCAD. Results In the Kaplan–Meier analysis, the long-term MACE (major adverse cardiac events) free survival rate of patients with high CAR levels decreased significantly (P = 0.015). Of the note, after adjusting for other covariates in multivariate analysis, CAR was still independently positively correlated with poor prognosis in SCAD patients (HR = 1.03, 95% CI:1.01–1.06, P = 0.02, P for trend = 0.024). Additionally, we identified a nonlinear association between CAR and poor prognosis of SCAD by the generalized additive model (GAM). Then, through the two-piecewise linear regression model, we calculated that the inflection point of CAR was 3.933 (log-likelihood ratio test P = 0.02). When CAR ≤ 3.933, there was a positive correlation between CAR and MACE in patients with SCAD (HR:1.48, 95% CI:1.10–1.99, P = 0.009). While on the right hand of the inflection point (CAR > 3.933), the positive correlation between the two tends to be saturated (HR:1.01, 95% CI:0.97–1.05, P = 0.64). Conclusions This study indicated an association between higher CAR levels and increased risk of MACE in patients with SCAD for the first time, and measurement of CAR at admission may be a valuable predictor of the prognostic outcome in patients with SCAD treated by the percutaneous coronary intervention.

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Prognostic efficacy of C-reactive protein/albumin ratio in ST elevation myocardial infarction

Cited by 81 publications

References 28 publications

C-Reactive Protein/Albumin Ratio as an Independent Predictor of Mortality in Critically Ill Pediatric Patients

C-Reactive Protein/Albumin Ratio as an Independent Predictor of Mortality in Critically Ill Pediatric Patients

C-reactive Protein to Albumin Ratio as A Novel Inflammatory Biomarker for Postoperative Delirium in Patients Undergoing Transcatheter Aortic Valve Replacement

The C-reactive protein to albumin ratio is a novel prognostic factor in patients with stable coronary artery disease following percutaneous coronary intervention

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