Prognostic effect of preoperative serum albumin to globulin ratio in patients treated with cytoreductive nephrectomy for metastatic renal cell carcinoma

Laukhtina, Ekaterina; Pradère, Benjamin; D’Andrea, David; Rosiello, Giuseppe; Luzzago, Stefano; Pecoraro, Angela; Palumbo, Carlotta; Knipper, Sophie; Karakiewicz, Pierre I.; Margulis, Vitaly; Quhal, Fahad; Motlagh, Reza Sari; Mostafaei, Hadi; Mori, Keiichiro; Schuettfort, Victor M.; Enikeev, Dmitry; Shariat, Shahrokh F.

doi:10.21037/tau-20-1101

Cited by 8 publications

(25 citation statements)

References 28 publications

(37 reference statements)

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“…Four studies with insufficient survival data were eliminated. Finally, data of 10 studies that included 3,180 patients ( 18 – 25 , 29 , 30 ) were analyzed in this meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

“…The total sample size was 3,180 and ranged from 31 to 646. Three studies were performed in Turkey ( 19 , 24 , 30 ), two in Italy ( 21 , 23 ), and one each in India ( 18 ), China ( 22 ), Japan ( 25 ), Austria ( 29 ), and Poland ( 20 ), respectively. The included studies were published between 2016 and 2021 and all were English publications.…”

Section: Resultsmentioning

confidence: 99%

“…The included studies were published between 2016 and 2021 and all were English publications. All 10 studies investigated the association between SII and OS ( 18 – 25 , 29 , 30 ), three investigated the association between SII and PFS ( 18 , 23 , 30 ), one between SII and DFS ( 24 ), and two between SII and CSS ( 22 , 29 ). Eight studies recruited patients with metastatic RCC ( 18 – 21 , 23 , 25 , 29 , 30 ), and two studies enrolled patients with localized disease ( 22 , 24 ).…”

Section: Resultsmentioning

confidence: 99%

“…All 10 studies investigated the association between SII and OS ( 18 – 25 , 29 , 30 ), three investigated the association between SII and PFS ( 18 , 23 , 30 ), one between SII and DFS ( 24 ), and two between SII and CSS ( 22 , 29 ). Eight studies recruited patients with metastatic RCC ( 18 – 21 , 23 , 25 , 29 , 30 ), and two studies enrolled patients with localized disease ( 22 , 24 ). The cut-off values of SII ranged from 529 to 1,375 (median 730).…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, subgroup analysis indicated that a cut-off level ≤730 was of prognostic value for poor PFS/DFS in patients with RCC (Table 2). Data obtained from two studies (22,29) showed that a high SII was not associated with poor CSS (pooled data HR 1.46, 95% CI 0.68-3.12, p=0.332) (Table 2 and Figure 4). Subgroup analysis of CSS was not performed because of the limited sample size.…”

Section: Association Between the Systemic Immune-inflammation Index And Survival Outcomes In Patients With Renal Cell Carcinomamentioning

confidence: 97%

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Prognostic and Clinicopathological Significance of the Systemic Immune-Inflammation Index in Patients With Renal Cell Carcinoma: A Meta-Analysis

Jin¹,

Yuan²,

Yuan

et al. 2021

Front. Oncol.

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BackgroundThe systemic immune-inflammation index (SII) is a hematological parameter based on neutrophil, platelet, and lymphocyte counts. Studies that have investigated the prognostic value of SII in patients with renal cell carcinoma (RCC) have reported controversial results. In this study, we systematically investigated the prognostic value of SII in patients with RCC.MethodsWe systematically searched English articles in the PubMed, Embase, Web of Science, and Cochrane Library databases up to October 2021. Hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were used to obtain pooled results.ResultsThe meta-analysis included 10 studies that enrolled 3,180 patients. A high SII was associated with poor overall survival (HR 1.75, 95% CI 1.33–2.30, p<0.001) in patients with RCC. However, a high SII was not shown to be a significant prognostic factor for progression-free survival/disease-free survival (HR 1.22, 95% CI 0.84–1.76, p=0.293) or poor cancer-specific survival (HR 1.46, 95% CI 0.68–3.12, p=0.332) in patients with RCC. A high SII was correlated with male sex (OR 1.51, 95% CI 1.11–2.04, p=0.008), Fuhrman grade G3–G4 (OR 1.80, 95% CI 1.08–3.00, p=0.024), and poor risk based on the International Metastatic Renal Cell Carcinoma Database Consortium criteria (OR 19.12, 95% CI 9.13–40.06, p<0.001).ConclusionA high SII was independently associated with poor survival outcomes in patients with RCC. Additionally, an elevated SII indicated more aggressive disease. The SII may serve as a useful cost-effective prognostic indicator in patients with RCC.

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“…Four studies with insufficient survival data were eliminated. Finally, data of 10 studies that included 3,180 patients ( 18 – 25 , 29 , 30 ) were analyzed in this meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Association Between the Systemic Immune-inflammation Index And Survival Outcomes In Patients With Renal Cell Carcinomamentioning

confidence: 97%

See 3 more Smart Citations

Prognostic and Clinicopathological Significance of the Systemic Immune-Inflammation Index in Patients With Renal Cell Carcinoma: A Meta-Analysis

Jin¹,

Yuan²,

Yuan

et al. 2021

Front. Oncol.

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Selection and evaluation of preoperative systemic inflammatory response biomarkers model prior to cytoreductive nephrectomy using a machine-learning approach

et al. 2021

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Introduction This study aimed to determine the prognostic value of a panel of SIR-biomarkers, relative to standard clinicopathological variables, to improve mRCC patient selection for cytoreductive nephrectomy (CN). Material and methods A panel of preoperative SIR-biomarkers, including the albumin–globulin ratio (AGR), De Ritis ratio (DRR), and systemic immune-inflammation index (SII), was assessed in 613 patients treated with CN for mRCC. Patients were randomly divided into training and testing cohorts (65/35%). A machine learning-based variable selection approach (LASSO regression) was used for the fitting of the most informative, yet parsimonious multivariable models with respect to prognosis of cancer-specific survival (CSS). The discriminatory ability of the model was quantified using the C-index. After validation and calibration of the model, a nomogram was created, and decision curve analysis (DCA) was used to evaluate the clinical net benefit. Results SIR-biomarkers were selected by the machine-learning process to be of high discriminatory power during the fitting of the model. Low AGR remained significantly associated with CSS in both training (HR 1.40, 95% CI 1.07–1.82, p = 0.01) and testing (HR 1.78, 95% CI 1.26–2.51, p = 0.01) cohorts. High levels of SII (HR 1.51, 95% CI 1.10–2.08, p = 0.01) and DRR (HR 1.41, 95% CI 1.01–1.96, p = 0.04) were associated with CSS only in the testing cohort. The exclusion of the SIR-biomarkers for the prognosis of CSS did not result in a significant decrease in C-index (− 0.9%) for the training cohort, while the exclusion of SIR-biomarkers led to a reduction in C-index in the testing cohort (− 5.8%). However, SIR-biomarkers only marginally increased the discriminatory ability of the respective model in comparison to the standard model. Conclusion Despite the high discriminatory ability during the fitting of the model with machine-learning approach, the panel of readily available blood-based SIR-biomarkers failed to add a clinical benefit beyond the standard model.

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Albumin levels predict prognosis in advanced renal cell carcinoma treated with tyrosine kinase inhibitors: a systematic review and meta-analysis

Zhou

et al. 2022

Urologic Oncology: Seminars and Original Investigations

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Prognostic effect of preoperative serum albumin to globulin ratio in patients treated with cytoreductive nephrectomy for metastatic renal cell carcinoma

Cited by 8 publications

References 28 publications

Prognostic and Clinicopathological Significance of the Systemic Immune-Inflammation Index in Patients With Renal Cell Carcinoma: A Meta-Analysis

Prognostic and Clinicopathological Significance of the Systemic Immune-Inflammation Index in Patients With Renal Cell Carcinoma: A Meta-Analysis

Selection and evaluation of preoperative systemic inflammatory response biomarkers model prior to cytoreductive nephrectomy using a machine-learning approach

Albumin levels predict prognosis in advanced renal cell carcinoma treated with tyrosine kinase inhibitors: a systematic review and meta-analysis

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