Prognostic Differences in Patients with Solitary and Multiple Spinal Metastases

Lun, Dengxing; Xu, Lina; Wang, Rui; Yang, Xiong‐gang; Yu, Xiuchun; Zhang, Guochuan; Hu, Yongcheng

doi:10.1111/os.12470

Cited by 9 publications

(6 citation statements)

References 41 publications

(72 reference statements)

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“…In our study, KPS scores at BM diagnosis less than 80 were associated with a worse prognosis compared to scores ranging from 80 to 100. This is in line with previous researches that have identified performance status as one of the most valuable prognostic factors for survival of BM patients (16)(17)(18).…”

Section: Discussionsupporting

confidence: 92%

“…J Gastrointest Oncol 2021 | http://dx.doi.org/10.21037/jgo-20-586 The multiple bone involvement was found to be an independent prognostic factor for CSS, similar to some previous studies (15,16). However, Lun et al reported there was no association between the number of bone metastases and survival (17). Such differences might due to the sample size and selection bias in different studies.…”

Section: Discussionsupporting

confidence: 76%

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A novel risk stratification for predicting prognosis of colorectal cancer patients with bone metastasis

Guan

et al. 2021

J Gastrointest Oncol

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Background: Our understanding in prognosis of bone metastasis (BM) from colorectal cancer (CRC) is limited. We aimed to establish a clinical risk stratification for individually predicting the survival of CRC patients with BM.Methods: A total of 200 CRC patients with BM were included in this study. Survival time from BM diagnosis was estimated using the Kaplan-Meier method. The multivariable COX regression model identified the risk factors on cancer specific survival (CSS). Based on weighted scoring system, the stratification model was constructed to classify patients with BM according to prognostic risk. Discrimination power and calibration ability of risk stratification were measured. Results:The median CSS time was 11 months after BM diagnosis. Lymph node metastasis, Carbohydrate antigen 199 (CA199) levels, bone involvement, Karnofsky Performance Status (KPS) scores, primary tumor resection, bisphosphonates therapy and radiotherapy were identified as predictors of CSS. Four risk groups were stratified according to weighted scoring system, including low risk, medium risk, medium-high risk and high risk group, with 35, 16, 9 and 5 months of median CSS, respectively (P=0.000). The risk stratification displayed good accuracy in predicting CSS, with acceptable discrimination and calibration.Conclusions: This novel risk stratification predicts CSS in CRC patient with BM using easily accessible clinicopathologic factors, which is recommended for use in individualized clinical decision making in patient with BM.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 76%

A novel risk stratification for predicting prognosis of colorectal cancer patients with bone metastasis

Guan

et al. 2021

J Gastrointest Oncol

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“…The multiple bone involvement was found to be an independent prognostic factor for CSS, similar to some previous studies [15,16]. However, Lun et al reported there was no association between the number of bone metastases and survival [17]. Such differences might due to the sample size and selection bias in different studies.…”

Section: Treatments For Bmsupporting

confidence: 82%

A novel risk stratification for predicting prognosis of colorectal cancer patients with bone metastasis

Guan

Quan

et al. 2020

Preprint

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Backgroud: Our understanding in prognosis of bone metastasis (BM) from colorectal cancer (CRC) is limited. We aimed to establish a clinical risk stratification for individually predicting the survival of CRC patients with BM.Methods: A total of 200 CRC patients with BM were included in this study. Survival time from BM diagnosis was estimated using the Kaplan-Meier method. The multivariable COX regression model identified the risk factors on cancer specific survival (CSS). Based on weighted scoring system, the stratification model was constructed to classify patients with BM according to prognostic risk. Discrimination power and calibration ability of risk stratification were measured.Results: The median CSS time was 11 months after BM diagnosis. Lymph node metastasis, CA199 levels, bone involvement, KPS scores, primary tumor resection, bisphosphonates therapy and radiotherapy were identified as predictors of CSS. Four risk groups were stratified according to weighted scoring system, including low risk, medium risk, medium-high risk and high risk group, with 35, 16, 9 and 5 months of median CSS, respectively (P = 0.000). The risk stratification displayed good accuracy in predicting CSS, with acceptable discrimination and calibration.Conclusion: This novel risk stratification predicts CSS in CRC patient with BM using easily accessible clinicopathologic factors, which is recommended for use in individualized clinical decision making in patient with BM.

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“…Токухаси и соавт. рекомендовал эксцизионную операцию для пациентов с хорошим прогнозом (оценка Токухаси 12-15), паллиативную операцию для большинства пациентов со средним прогнозом (оценка 9-11) и консервативное лечение для пациентов с оценкой 8 или менее баллов [8,45,46,47]. Они проспективно применили свою систему подсчета баллов к 118 пациентам, чтобы помочь определить хирургическую стратегию, и обнаружили хорошую корреляцию между прогностическим показателем и фактической выживаемостью (r = 0,57, значительный P <0,0001), с коэффициентом согласованности между прогнозируемой и фактической выживаемостью 86,4.…”

Section: рис 3 классификация Weinsteinunclassified

Review of Classifications and Scoring Systems for Metastatic Spine Tumors Used in Surgical Treatment

Korzh¹,

Kutsenko²,

Perfiliev³

et al. 2020

Ukr. ž. med. bìol. sportu

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It is known that metastases in the spine are detected in more than 70% of cancer patients, and in 10% of such patients, compression of nerve structures and severe neurological disorders develop. The role of surgery for metastatic tumors of the spine is in the focus of attention, since the operation can improve mechanical stability, decompress nerve structures and reduce the intensity of pain. However, what role the operation plays in increasing life expectancy and how to correctly assess the results of treatment remains controversial and the opinions of specialists are controversial, since the assessment is often made by oncologists, but it is the surgeon who more fully evaluates the potential risks and benefits of surgical interventions. Therefore, it is important for surgeons to understand what prognostic factors affect the quality and duration of life. This article presents the most cited classifications and assessments before 2009, as well as all classifications and assessments obtained after 2010 regarding metastatic lesions of the spine, as well as classifications used to develop treatment tactics obtained from the electronic databases PubMed, MEDLINE, articles, monographs, abstracts, dissertations and other sources of scientific and medical information. 57 main publications with II and III levels of evidence were selected, 6 classifications and 24 rating scales were considered. In order to construct the necessary tactics of the surgical strategy, the classification / assessment methods were divided into anatomical classification / assessment methods, neurological symptom / instability assessment methods, and assessment systems for predicting life expectancy. The study showed that in the surgical treatment of metastatic tumors of the spine, it is important to use the same rating scales and classifications to select indications and assess the results of surgical treatment, as well as to achieve meaningful comparisons between published series. Conclusion. The classifications and rating scales used for metastatic lesions of the spine do not fully reflect the type of surgical treatment: there is no algorithm for restoring the support ability of the spine, which is very important for this category of patients

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Prognostic Differences in Patients with Solitary and Multiple Spinal Metastases

Cited by 9 publications

References 41 publications

A novel risk stratification for predicting prognosis of colorectal cancer patients with bone metastasis

A novel risk stratification for predicting prognosis of colorectal cancer patients with bone metastasis

A novel risk stratification for predicting prognosis of colorectal cancer patients with bone metastasis

Review of Classifications and Scoring Systems for Metastatic Spine Tumors Used in Surgical Treatment

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