Prognostic CT findings of malignant bowel obstruction in patients with advanced ovarian cancer

Abstract

Objective: To evaluate computed tomography (CT) findings able to predict outcome in patients with ovarian cancer (OC) and concomitant bowel occlusion. Methods: This institutional review board–approved retrospective study included 31 patients with OC and clinical evidence of bowel occlusion who underwent CT at presentation between February 2013 and June 2015. Two radiologists recorded various qualitative CT features. Correlations between CT and survival data were made with Mann-Whitney test, Wilcoxon test, and χ2 test, as appropriate. Receiver operating characteristic curves were generated for statistically significant CT findings using logistic regression model. Results: Two of 31 patients (6.5%) were alive at the end of this study; 29 patients (93.5%) died of disease. Median overall survival was 90 days. CT features associated with short life expectancy were bowel mural thinning ( p=0.03), mesenteric tumor deposits ( p=0.009), mesenteric infiltration ( p=0.02), and ascites ( p=0.04). Area under the curve was 0.728 ( p=0.03) for mesenteric tumor deposits in predicting malignant bowel obstruction. Conclusions: Accurate interpretation of CT features may guide decisions in care of women with OC and bowel obstruction.

Abdominal Computed Tomography Enhanced Image Features under an Automatic Segmentation Algorithm in Identification of Gastric Cancer and Gastric Lymphoma

“…The open operation [ 17 ] refers to etching first and then expanding, which can eliminate small areas with higher brightness, separate objects at slender points, etc., which is expressed as the following equation. …”

Prognostic Factors for Surgical Failure in Malignant Bowel Obstruction and Peritoneal Carcinomatosis

“…We reviewed the clinical records of all consecutive patients with MBO due to PM who underwent palliative surgery. The diagnosis of MBO was established on clinical and CT-scan findings (10)(11)(12).…”

Inoperable Bowel Obstruction in Ovarian Cancer: Prevalence, Impact and Management Challenges

“… 16–23 Moreover, a recent retrospective review identified CT findings of ascites, mesenteric disease, and dilated bowel loop wall thinning as poor prognostic indicators. 24 …”

“…[16][17][18][19][20][21][22][23] Moreover, a recent retrospective review identified CT findings of ascites, mesenteric disease, and dilated bowel loop wall thinning as poor prognostic indicators. 24 Retrospective analyses have shown that systemic chemotherapy after the development of MBO is associated with superior survival, irrespective of whether patients were treated medically or surgically for MBO. [25][26][27] In advanced ovarian cancer, disease status is an important prognostic factor of treatment response and thus MBO outcome.…”