Prognostic criteria in an epidemiological group of patients with multiple sclerosis: an exploratory study

Lauer, Klaus; Firnhaber, W

doi:10.1007/bf00862981

Cited by 12 publications

(4 citation statements)

References 36 publications

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“…According to some previous studies, the initial cerebellar, 9,36 psychiatric and urinary symptoms, 21,29 were found to be the unfavourable features. On the other hand, the presence of sensory symptoms at onset was frequently reported to indicate the better prognosis.…”

Section: Discussionmentioning

confidence: 91%

Prognostic factors for survival in multiple sclerosis

et al. 1999

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In a hospital-based study of 119 patients with definite multiple sclerosis, demographic and clinical factors were analysed with respect to their validity in assessing the long-term prognosis. Over a mean follow-up of 21.7 years, the following factors negatively influenced the prognosis by the univariate analysis: male sex, age at onset over 25, pyramidal involvement or spasticity at onset, > or =3 functional systems affected at onset or after 5 years, incomplete first remission, length of the first remission < or =1 year, >5 attacks in the first 10 years, secondary or primary-progressive disease, time to reach secondary progression over 5 years and time to reach EDSS 6 over 7 years. The multivariate model showed that in patients with relapsing-remitting disease, 5 years after onset, pyramidal involvement at onset and shorter time to reach EDSS 6 predicted poor outcome, while after 10 years, higher age at onset and incomplete first remission indicated poor prognosis. Ten years after onset, the predictors of poor outcome in the secondary-progressive group were shorter time to reach EDSS 6 or secondary progression and higher EDSS, while in the primary-progressive group those variables were spasticity or higher number of functional systems affected at onset, and higher EDSS after 5 and 10 years.

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Section: Discussionmentioning

confidence: 91%

Prognostic factors for survival in multiple sclerosis

et al. 1999

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“…Buffer density ( ρ = 1.0347 g ml −1 ) and viscosity ( η = 0.0138 Poise) at 20°C, measured with a picnometer and a Ubehlode viscometer were used to correct the sedimentation coefficient values to standard conditions (s 20,w , viscosity and density of the water, and 20°C). SEDNTERP software (Lauer and Firnhaber, ) was used to estimate the partial specific volume of PctA‐LBR and PctB‐LBR (0.737 and 0.731 ml g −1 respectively) from the amino acid sequence. Sedimentation equilibrium (SE) data were acquired for 150 μl samples, using 150 μl polybuffer as reference, at three different speeds (13 500, 22 000 and 27 000 r.p.m.)…”

Section: Methodsmentioning

confidence: 99%

Paralogous chemoreceptors mediate chemotaxis towards protein amino acids and the non‐protein amino acid gamma‐aminobutyrate (GABA)

Rico-Jiménez

Muñoz-Martínez

García-Fontana

et al. 2013

Molecular Microbiology

134

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SummaryThe paralogous receptors PctA, PctB and PctC of Pseudomonas aeruginosa were reported to mediate chemotaxis to amino acids, intermediates of amino acid metabolism and chlorinated hydrocarbons. We show that the recombinant ligand binding regions (LBRs) of PctA, PctB and PctC bind 17, 5 and 2 L-amino acids respectively. In addition, PctC-LBR recognized GABA but not any other structurally related compound. L-Gln, one of the three amino acids that is not recognized by PctA-LBR, was the most tightly binding ligand to PctB suggesting that PctB has evolved to mediate chemotaxis primarily towards L-Gln. Bacteria were efficiently attracted to L-Gln and GABA, but mutation of pctB and pctC, respectively, abolished chemoattraction. The physiological relevance of taxis towards GABA is proposed to reside in an interaction with plants. LBRs were predicted to adopt double PDC (PhoQ/DcuS/CitA) like structures and site-directed mutagenesis studies showed that ligands bind to the membrane-distal module. Analytical ultracentrifugation studies have shown that PctA-LBR and PctB-LBR are monomeric in the absence and presence of ligands, which is in contrast to the enterobacterial receptors that require sensor domain dimers for ligand recognition.

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“…Despite these differences, the overall trend of longitudinal studies has been that benign MS is a temporary condition [2,4,5,12,14,34]. Population-based cohorts tend to have more benign cases than hospital-based cohorts, while a longer follow-up time tends to give fewer benign cases compared to a shorter follow-up time because of the increasing conversion from benign to nonbenign disease over time [7,12,26,36].…”

Section: Longitudinal Trend Of Benign Ms From 1995 To 2003mentioning

confidence: 99%