Prognostic and therapeutic roles of SETD2 in cutaneous melanoma
Jiani Xiong,
Liping Zhu,
Yunrong Fu
et al.
Abstract:Background: Cutaneous melanoma (CM) is an aggressive form of skin cancer with limited treatment options for advanced stages. Prognostic markers that accurately predict patients’ outcomes and guide therapeutic strategies are crucial for improving melanoma management. SETD2 (SET Domain-Containing Protein 2), a histone methyltransferase involved in chromatin remodeling and gene regulation, has recently emerged as a tumor suppressor. Its dysfunction is involved in oncogenesis in some cancers, but little is known a… Show more
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