Prognostic and Therapeutic Implications of Urinary Gonadotropin Levels in the Management of Testicular Neoplasia

Wilson, James M.; Woodhead, David M.

doi:10.1016/s0022-5347(17)60860-7

Cited by 24 publications

(6 citation statements)

References 7 publications

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“…Increased levels of serum and urinary gonadotrophin have been pointed out as valuable biochemical tumour markers in patients with testicular germ cell tumours (Cochran et al 1975;Javadpour et al 1978;Scardino et al 1977;Wilson & Woodhead 1972). This is in our study confirmed by the fact that increased LH levels'were found in 15 out of 29 patients at the initial detection of metastases.…”

Section: Discussionsupporting

confidence: 85%

“…The significance of serum hCG determinations in patients with testicular germ cells tumours has clearly been demonstrated in the literature (Cochran et al 1975;Einhorn & Donohue 1977;Javadpour et al 1978;Scardino et al 1977;Wilson & Woodhead 1972). Cochran et al (1975) have also found decreased mean serum FSH levels and increased serum oestradiol levels in patients with metastatic testicular cancer.…”

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confidence: 92%

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Endocrinological Studies in Patients with Metastatic Malignant Testicular Germ Cell Tumours

et al. 1980

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In this study, various serum hormone levels were determined in patients with metastatic testicular germ cell tumours. Raised LH levels, due to a cross reaction with hCG in the radioimmunoassay, were observed in 20 out of 29 patients with active disease and were mainly caused by gonadotrophin production in the tumour tissue. Increased LH levels were frequently observed in the patients with non-seminomatous tumours, but were also found in 4 (out of 6) patients with metastatic seminoma. One should, however, preferably use a specific hCG radioimmunoassay in order to measure tumour hCG as a tumour marker with a high diagnostic accuracy. In patients with active disease despite ongoing combination chemotherapy which included LH suppressing medication, serum testosterone remained above 6 nmol/l in 11 out of 16 patients. These patients remained sexually potent, while testosterone values below 6 nmol/l usually were combined with sexual impotence in patients during combination chemotherapy. These data strongly suggest that the tumour hCG has a biological activity, stimulating the remaining testis to increased testosterone secretion in these patients. The serum E2-17 beta levels were slightly to moderately increased in half of the patients with metastatic disease. Markedly increased serum E2-17 beta levels (> 0.30 nmol/l) and very high prolactin values (> 32 micrograms/l) were observed only in patients with high LH levels (> 9.5 micrograms/l) and a large tumour burden. These observations indicate that E2-17 beta and prolactin determinations are of minor value for early detection of tumour manifestations. Serum FSH cannot serve as a tumour marker in patients with testicular germ cell tumours.

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Section: Discussionsupporting

confidence: 85%

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confidence: 92%

Endocrinological Studies in Patients with Metastatic Malignant Testicular Germ Cell Tumours

et al. 1980

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“…lncreased LH levels, as determined by the RIA used in the present study, may also reflect increased HCG levels produced by tumour cells (Wilson and Woodhead. 1972;Cochran ef al., 1975;Scardino ef al., 1977).…”

Section: Discussionmentioning

confidence: 67%

“…It is known that urinary and/or serum choriogonadotrophin (Wilson and Woodhead, 1972; Cochran el al., 1975; Scardino et a / . , 1977) as well as oestrogen (Cochran et al, 1975) may be elevated in patients with testicular cancer.…”

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confidence: 99%

Serum Hormone Levels in Patients with Malignant Testicular Germ Cell Tumours without Clinical and/or Radiological Sings of Tumour

Fosså¹,

Klepp²,

Aakvaag³

1980

British Journal of Urology

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In patients treated for malignant testicular tumours without clinical and/or radiological signs of tumour, the following serum hormone levels were found: In 15% of the patients there was a slight to moderate rise in luteinising hormone (LH) levels (up to 6 micrograms/l) due to increased pituitary gonadotrophin production; this was particularly evident soon after radiotherapy/chemotherapy. In 50% of the patients there was a slight to marked increase in follicle stimulating hormone (FSH) levels (up to 11 micrograms/l), especially after radiotherapy/chemotherapy. Serum testosterone levels were in the low range (up to 20 nmol/l) in the majority of the hemicastrated patients regardless of previous treatment. A slight to moderate rise in serum oestradiol-17 beta and serum prolactin levels was noted. During combination chemotherapy with vincristine, Adriamycin D, cyclophosphamide, actinomycin D and medroxyprogesterone acetate the serum testosterone levels were extremely low (below 6 nmol/l) with LH and FSH levels within the normal range. The decrease in testosterone levels was reversible after completion of the combination chemotherapy.

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“…This figure is within the range of published data based on morphological appearances or HCG production. Since, as shown in Table II (Javadpour et al, 1978;Hedinger et al, 1979;Mostofi, 1980;Bosman et al, 1980 (Dixon & Moore, 1952;Wilson & Woodhead, 1972;Maier & Sulak, 1973 (Cochran et al, 1975;Bartsch et al, 1979;Javadpour, 1980Javadpour, , 1983 but there is still no concensus as to its prognostic significance. Lange et al (1980) suggest that this finding in association with metastatic seminoma is a poor prognostic sign and indicates the use of chemotherapy.…”

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The biological and clinical significance of HCG-containing cells in seminoma

Butcher¹,

Gregory²,

Gunter³

et al. 1985

Br J Cancer

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Prognostic and Therapeutic Implications of Urinary Gonadotropin Levels in the Management of Testicular Neoplasia

Cited by 24 publications

References 7 publications

Endocrinological Studies in Patients with Metastatic Malignant Testicular Germ Cell Tumours

Endocrinological Studies in Patients with Metastatic Malignant Testicular Germ Cell Tumours

Serum Hormone Levels in Patients with Malignant Testicular Germ Cell Tumours without Clinical and/or Radiological Sings of Tumour

The biological and clinical significance of HCG-containing cells in seminoma

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