Prognostic and predictive value of long non-coding RNA GAS5 and mircoRNA-221 in colorectal cancer and their effects on colorectal cancer cell proliferation, migration and invasion

Liu, Lin; Meng, Tao; Yang, Xinggang; Sayim, Parhat; Liu, Cheng; Jin, Bo; Liu, Ge; Wang, Haijiang

doi:10.3233/cbm-171011

Cited by 97 publications

(85 citation statements)

References 32 publications

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“…43 Reduced GAS5 facilitated colon cancer cell migration, proliferation and invasion. 44 Downregulated GAS5 also promoted the cell cycle in the G0/ G1 stage and prevented apoptosis. Increased GAS5 was an independent marker of a longer overall survival and better prognosis.…”

Section: Snhgs In Colorectal Cancermentioning

confidence: 97%

“…Yuan et al found that co‐overexpressed GAS5 and SNORD44 could significantly repress tumor growth and they could induce cancer cells apoptosis in both vivo and vitro . The overexpression of GAS5 could suppress colon cancer cells proliferation and promote apoptosis by inhibiting the expression of MIR‐182‐5p and MIR‐221 , but upregulating FOXO3a …”

Section: Biological Functions and Mechanisms Of Snhgs In Digestive Camentioning

confidence: 99%

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Long non‐coding small nucleolar RNA host genes in digestive cancers

et al. 2019

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Although long noncoding RNAs (lncRNAs) do not have protein coding capacities, they are involved in the pathogenesis of many types of cancers, including hepatocellular carcinoma, cervical cancer, and gastric cancer. Notably, the roles of lncRNAs are vital in nearly every aspect of tumor biology. Long non‐coding small nucleolar RNA host genes (lnc‐SNHGs) are abnormally expressed in multiple cancers, including urologic neoplasms, respiratory tumors, and digestive cancers, and play vital roles in these cancers. These host genes could participate in tumorigenesis by regulating proliferation, migration, invasion and apoptosis of tumor cells. This review focuses on the overview of the roles that lnc‐SNHGs play in the formation and progression of digestive cancers.

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Section: Snhgs In Colorectal Cancermentioning

confidence: 97%

Section: Biological Functions and Mechanisms Of Snhgs In Digestive Camentioning

confidence: 99%

Long non‐coding small nucleolar RNA host genes in digestive cancers

et al. 2019

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“…Nevertheless, in a recent observation, it was demonstrated that lncRNA GAS5 conduces to lymphatic metastasis of CRC (19). Additionally, using qRT-PCR, Liu et al detected upregulation of lncRNA GAS5 and downregulation of miR-221 in CRC (20). Surprisingly, the level of lncRNA GAS5 is also related to clinical and pathological features (20).…”

Section: Lncrnas and Dna Transcriptionmentioning

confidence: 99%

“…Additionally, using qRT-PCR, Liu et al detected upregulation of lncRNA GAS5 and downregulation of miR-221 in CRC (20). Surprisingly, the level of lncRNA GAS5 is also related to clinical and pathological features (20). Therefore, the mechanism of lncRNA GAS5 in CRC warrants further study and confirmation.…”

Section: Lncrnas and Dna Transcriptionmentioning

confidence: 99%

Emerging Roles of lncRNAs in the Formation and Progression of Colorectal Cancer

Long

Yin

et al. 2020

Front. Oncol.

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Colorectal cancer (CRC) is the primary cause of cancer-related death worldwide; however, specific and sensitive tools for the early diagnosis and targeted therapy of CRC are currently lacking. High-throughput sequencing technology revealed that gene expression of long-chain non-coding RNAs (lncRNAs) in a number of cancers directly or indirectly interferes with various biological processes. Emerging evidence suggests that lncRNAs regulate target genes and play an important role in the biological processes of malignancies, including CRC. Many carcinostatic/oncogenic lncRNAs have been identified as biomarkers for metastasis and prognosis in CRC; hence, they serve as therapeutic tools. In this article, we systematically review the literature on the disordered lncRNAs in CRC from four aspects: DNA transcription, RNA level regulation, post-translational level, and the translation of lncRNAs into polypeptides. Subsequently, we analyze the mechanism through which lncRNAs participate in the biological process of CRC. Finally, we discuss the application and prospects of these lncRNAs in CRC.

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“…In addition, microarray results indicated that the expression of the lncRNA GAS5 was decreased in SKBR-3/Tr cells and breast cancer tissues from trastuzumab-treated patients, suggesting that GAS5 may serve as a novel prognostic marker and candidate drug target for HER2-positive breast cancer (57). Collectively, the prognostic values of these lncRNAs for patients with cancer were assessed by meta-analysis, which may facilitate improvements in the diagnosis and prognosis of cancer treatment (58)(59)(60). Although the majority of pioneering studies remain in the early stage, they still encourage further examination of the diagnostics and therapeutic opportunities of lncRNAs in cancer.…”

Section: Cancer Diagnostics and Therapies Based On Genome-wide Analysmentioning

confidence: 99%

Genome‑wide analysis reveals the emerging roles of long non‑coding RNAs in cancer (Review)

Ren

2019

Oncol Lett

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Cancer is the most intractable human disease that is primarily caused by genetic alterations. Recently, the general application of microarrays and high-throughput sequencing technology has revealed various important roles of long noncoding RNAs (lncRNAs) in cancer. This review summarizes the function, mechanism, diagnostic and treatment potential of lncRNAs identified through genome-wide analysis in cancer. Cell-, tissue-and development stage-specific expression patterns are major characteristics of cancer-associated lncRNAs, and various genetic alterations are also implicated. Microarray and sequencing analyses serve important roles in mechanistic studies of either nuclear or cytoplasmic lncRNAs. Collectively, genome-wide analysis is the inexorable trend of future studies or clinical applications of lncRNAs and offers a novel perspective regarding the prognosis and treatment of cancer. Contents 1. Introduction 2. Identification of lncRNAs in cancer using genome analysis 3. Mechanisms of lncRNAs identified by genome-wide analyses in cancer 4. Cancer diagnostics and therapies based on genome-wide analysis of lncRNAs 5. Conclusion and future perspective

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Prognostic and predictive value of long non-coding RNA GAS5 and mircoRNA-221 in colorectal cancer and their effects on colorectal cancer cell proliferation, migration and invasion

Cited by 97 publications

References 32 publications

Long non‐coding small nucleolar RNA host genes in digestive cancers

Long non‐coding small nucleolar RNA host genes in digestive cancers

Emerging Roles of lncRNAs in the Formation and Progression of Colorectal Cancer

Genome‑wide analysis reveals the emerging roles of long non‑coding RNAs in cancer (Review)

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