Prognostic and predictive value of liver volume in colorectal cancer patients with unresectable liver metastases

Park, Jun Su; Park, Hee Chul; Choi, Doo Ho; Park, Won; Yu, Jeong Il; Park, Young Suk; Kang, Won Ki; Park, Joon Oh

doi:10.3857/roj.2014.32.2.77

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…Similar to the results of other prospective and retrospective low-dose WLI studies [ 12 16 20 ], most patients in our trial tolerated combination treatments of low-dose WLI and hyperthermia. Grade III or higher adverse events developed because of either distant or intrahepatic disease progression.…”

Section: Discussionsupporting

confidence: 86%

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Prospective phase II trial of regional hyperthermia and whole liver irradiation for numerous chemorefractory liver metastases from colorectal cancer

Park

Choi

et al. 2016

Radiat Oncol J

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PurposeA prospective phase II trial was conducted to evaluate the effectiveness and toxicity of regional hyperthermia and whole liver irradiation (WLI) for numerous chemorefractory liver metastases from colorectal cancer.Materials and MethodsEnrolled patients had numerous chemorefractory hepatic metastases from colorectal cancer. Five sessions of hyperthermia and seven fractions of 3-gray WLI were planned. Health-related quality of life (HRQoL) was determined using the Korean version of the European Organization for Research and Treatment of Cancer quality of life questionnaire C-30 and the Functional Assessment of Cancer Therapy-Hepatobiliary version 4.0. Objective and pain response was evaluated.ResultsA total of 12 patients consented to the study and the 10 who received WLI and hyperthermia were analyzed. WLI was completed as planned in nine patients and hyperthermia in eight. Pain response was partial in four patients and stable in four. Partial objective response was achieved in three patients (30.0%) and stable disease was seen in four patients at the 1-month follow-up. One patient died 1 month after treatment because of respiratory failure related to pleural metastasis progression. Other grade III or higher toxicities were detected in three patients; however, all severe toxicities were related to disease progression rather than treatment. No significant difference in HRQoL was noted at the time of assessment for patients who were available for questionnaires.ConclusionCombined WLI and hyperthermia were well tolerated without severe treatment-related toxicity with a promising response from numerous chemorefractory hepatic metastases from colorectal cancer.

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Section: Discussionsupporting

confidence: 86%

“…Our group previously reported the results of a retrospective study of WLI as 21 Gy in 7 fractions in 16 patients with hepatic metastasis of colorectal cancer [ 20 ]. Palliation of abdominal pain was acceptable, but median overall survival was only 9 weeks.…”

Section: Discussionmentioning

confidence: 99%

Prospective phase II trial of regional hyperthermia and whole liver irradiation for numerous chemorefractory liver metastases from colorectal cancer

Park

Choi

et al. 2016

Radiat Oncol J

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“…32 Jiang et al 33 reported that the increase in ALT was associated with liver metastasis and, thus, a worse prognosis in colorectal cancer cases. In a similar study, Park et al 34 also showed that liver volume and liver function tests were negatively associated with survival in patients with colorectal cancer. Similarly, our study found that serum ALT level at the beginning of follow-up in colon cancer cases was negatively correlated with progressionfree and overall survival time.…”

Section: Discussionmentioning

confidence: 79%

The role of initial sodium and globulin values in the prognosis prediction of patients diagnosed with colon cancer

Yavas¹,

Çi̇fci̇²,

Keleş³

2023

JCHOR

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Aims: Early prediction of prognosis in malignancies can help determine life expectancy and take necessary further measures accordingly. There is no consensus on using any biomarker in predicting prognosis in colon cancer cases. A study reported that the sodium/globulin ratio is a valuable biomarker in predicting the prognosis of gastric cancer. This study aimed to investigate the role of baseline sodium, globulin, and sodium/globulin ratio in the prediction of prognosis and survival in colon cancer cases. Methods: The files of patients diagnosed with colon cancer who applied to Kırıkkale University Faculty of Medicine Medical Oncology Clinic between January 1, 2015, and December 31, 2020, were retrospectively analyzed. The relationship between the clinical and laboratory characteristics of the cases and their progression and survival were investigated. Results: 140 patients diagnosed with colon cancer were included in the study (82 men, 58 women). The average age at diagnosis was 64.1±12.6 years, 99.3% of them were adenocarcinoma, and 32.9% of them were stage 4 cancers. It was determined that 42.1% of the patients died (average survival time 54.0±3.2 months), and progression developed in 18.6% during the study period. The average baseline sodium/globulin ratio was 51.10±8.70. No significant correlation was found between initial serum sodium level, globulin level, sodium/globulin ratio, survival time, and progression status (p>0.05). Baseline serum globulin level showed a weak negative correlation with both progression-free and overall survival time (r=-0.23, p<0.05 and r=-0.24, p<0.05, respectively), while the sodium/globulin ratio showed a weak positive correlation with progression-free survival time (r=0.26, p<0.01) and overall survival time (r=0.25, p<0.01). The ROC curve analysis determined that initial serum sodium and globulin levels and sodium/globulin ratio were not predictive of progression and survival at any cut-off point (p>0.05). Conclusion: Although baseline serum sodium level, globulin level, and serum sodium/globulin ratio were weakly correlated with progression-free and overall survival time of patients diagnosed with colon cancer, they were not valuable in predicting progression and survival.

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18F-fluorodeoxyglucose positron emission tomography (18FDG-PET) for patients with biliary tract cancer: Systematic review and meta-analysis

Lamarca

Barriuso

Chander

et al. 2019

Journal of Hepatology

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Prognostic and predictive value of liver volume in colorectal cancer patients with unresectable liver metastases

Cited by 4 publications

References 19 publications

Prospective phase II trial of regional hyperthermia and whole liver irradiation for numerous chemorefractory liver metastases from colorectal cancer

Prospective phase II trial of regional hyperthermia and whole liver irradiation for numerous chemorefractory liver metastases from colorectal cancer

The role of initial sodium and globulin values in the prognosis prediction of patients diagnosed with colon cancer

18F-fluorodeoxyglucose positron emission tomography (18FDG-PET) for patients with biliary tract cancer: Systematic review and meta-analysis

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