Prognostic and predictive impact of NOTCH1 in early breast cancer
Julia Engel,
Vanessa Wieder,
Marcus Bauer
et al.
Abstract:Purpose
Systemic therapy plays a major part in the cure of patients with early breast cancer (eBC). However, personalized treatment concepts are required to avoid potentially harmful overtreatment. Biomarkers are pivotal for individualized therapy. The Notch signalling pathway is widely considered as a suitable prognostic or predictive marker in eBC. This study aimed primarily at assessing the relationship between NOTCH1 mRNA expression levels and histopathological features of breast cancer tumor… Show more
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