Prognostic and Predictive Biomarkers in Gliomas

Śledzińska, Paulina; Bebyn, Marek; Furtak, Jacek; Kowalewski, Janusz; Lewandowska, Marzena Anna

doi:10.3390/ijms221910373

Cited by 134 publications

(114 citation statements)

References 273 publications

Supporting

Mentioning

112

Contrasting

Unclassified

Order By: Relevance

“…While several neuroimaging methods are now used in clinical practice, glioma classification and grading by magnetic resonance imaging (MRI) is <35% accurate [ 2 ]. Moreover, the fifth edition of the WHO Classification of Tumors of the Central Nervous System (WHO CNS5) 2021 places significant emphasis on molecular diagnostics for accurate classification [ 5 ], so tissue samples are required for state-of-the-art glioma stratification [ 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Infratentorial Stereotactic Biopsy of Brainstem and Cerebellar Lesions

Furtak¹,

Śledzińska

Bebyn

et al. 2021

Brain Sciences

Self Cite

View full text Add to dashboard Cite

Stereotactic biopsy of posterior fossa lesions is often regarded as hazardous due to the critical structures in that area. Therefore, the aim of the study was to evaluate the diagnostic accuracy and safety of infratentorial stereotactic biopsy of brainstem or cerebellar lesions and its associations with other clinical, laboratory, and radiological parameters. From January 2000 to May 2021, 190 infratentorial stereotactic biopsies of posterior fossa tumors, including 108 biopsies of brainstem lesions, were performed. Moreover, 63 supratentorial biopsies of cerebral peduncle lesions were analyzed to compare the safety and efficacy of both approaches. Additionally, the presence of antibodies against Toxoplasma gondii and Epstein–Barr Virus (EBV) were documented in 67 and 66 patients, respectively, and magnetic resonance imaging (MRI) scans were evaluated in 114 patients. Only 4% of patients had minor complications and 1.5% had major complications, including one patient who died from intracranial bleeding. Nine (4.7%) biopsies were non-diagnostic. Isocitrate dehydrogenase 1 (IDH1) mutation, 1p/19q codeletion, and O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status were assessed in 29 patients, and were non-diagnostic in only 3 (10.3%) cases. Patients with high-grade gliomas (HGG) were more frequently seropositive for T. gondii than individuals with low-grade gliomas (LGG; p < 0.001). A total of 27% of HGG and 41% of LGG were non-enhancing on MRI. The infratentorial approach is generally safe and reliable for biopsy of brainstem and cerebellar lesions. In our study, the safety and efficacy of supratentorial biopsy of the cerebral peduncle and infratentorial biopsy of lesions below the cerebral peduncle were comparably high. Moreover, patients with HGG were more frequently seropositive for T. gondii than patients with LGG, and the relationship between toxoplasmosis and gliomagenesis requires further investigation.

show abstract

Section: Introductionmentioning

confidence: 99%

Infratentorial Stereotactic Biopsy of Brainstem and Cerebellar Lesions

Furtak¹,

Śledzińska

Bebyn

et al. 2021

Brain Sciences

Self Cite

View full text Add to dashboard Cite

show abstract

“…Nevertheless, a recent study developed a glioma epigenetic liquid biopsy score called GeLB [ 40 ]; this score is capable of distinguishing glioma patients (GeLB > 50%) with high specificity and sensibility. Because of this capability, GeLB could be useful in early diagnosis and [ 39 ] personalized tumor evaluation [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Liquid Biopsy in Diagnosis and Prognosis of High-Grade Gliomas; State-of-the-Art and Literature Review

Bonosi

Ferini²,

Giammalva

et al. 2022

Life

View full text Add to dashboard Cite

Gliomas, particularly high-grade gliomas, represent the most common and aggressive tumors of the CNS and are still burdened by high mortality and a very poor prognosis, regardless of the type of therapy. Their diagnosis and monitoring rely on imaging techniques and direct biopsy of the pathological tissue; however, both procedures have inherent limitations. To address these limitations, liquid biopsies have been proposed in this field. They could represent an innovative tool that could help clinicians in the early diagnosis, monitoring, and prognosis of these tumors. Furthermore, the rapid development of next-generation sequencing (NGS) technologies has led to a significant reduction in sequencing cost, with improved accuracy, providing a molecular profile of cancer and leading to better survival results and less disease burden. This paper focuses on the current clinical application of liquid biopsy in the early diagnosis and prognosis of cancer, introduces NGS-related methods, reviews recent progress, and summarizes challenges and future perspectives.

show abstract

“…Oligodendroglioma has a better outcome with a 5-year survival rate of 80% [ 17 ]. Whereas grade IV glioma (glioblastoma) is the most aggressive form of glioma, is characterized by a 5-year survival rate of 5%, and accounts for approximately 15% of all primary brain and CNS cancers and 55% of all gliomas [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Natural Compounds as Promising Adjuvant Agents in The Treatment of Gliomas

Persano

Gigli

Leporatti

2022

IJMS

View full text Add to dashboard Cite

In humans, glioblastoma is the most prevalent primary malignant brain tumor. Usually, glioblastoma has specific characteristics, such as aggressive cell proliferation and rapid invasion of surrounding brain tissue, leading to a poor patient prognosis. The current therapy—which provides a multidisciplinary approach with surgery followed by radiotherapy and chemotherapy with temozolomide—is not very efficient since it faces clinical challenges such as tumor heterogeneity, invasiveness, and chemoresistance. In this respect, natural substances in the diet, integral components in the lifestyle medicine approach, can be seen as potential chemotherapeutics. There are several epidemiological studies that have shown the chemopreventive role of natural dietary compounds in cancer progression and development. These heterogeneous compounds can produce anti-glioblastoma effects through upregulation of apoptosis and autophagy; allowing the promotion of cell cycle arrest; interfering with tumor metabolism; and permitting proliferation, neuroinflammation, chemoresistance, angiogenesis, and metastasis inhibition. Although these beneficial effects are promising, the efficacy of natural compounds in glioblastoma is limited due to their bioavailability and blood–brain barrier permeability. Thereby, further clinical trials are necessary to confirm the in vitro and in vivo anticancer properties of natural compounds. In this article, we overview the role of several natural substances in the treatment of glioblastoma by considering the challenges to be overcome and future prospects.

show abstract

Prognostic and Predictive Biomarkers in Gliomas

Cited by 134 publications

References 273 publications

Infratentorial Stereotactic Biopsy of Brainstem and Cerebellar Lesions

Infratentorial Stereotactic Biopsy of Brainstem and Cerebellar Lesions

Liquid Biopsy in Diagnosis and Prognosis of High-Grade Gliomas; State-of-the-Art and Literature Review

Natural Compounds as Promising Adjuvant Agents in The Treatment of Gliomas

Contact Info

Product

Resources

About