Prognostic and Predictive Biomarkers in Precursor B-cell Acute Lymphoblastic Leukemia

Zhang, Lei; Habeebu, Sahibu Sultan M; Li, Weijie

doi:10.36255/exon-publications-leukemia-biomarkers-lymphoblastic-leukemia

Cited by 3 publications

(2 citation statements)

References 83 publications

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“…Diversos trabalhos mostraram que a insulina e a IGF1, via IR e IGF1R, podem atuar de forma autócrina e parácrina em células de LLA promovendo o crescimento e proliferação destes tipos celulares. Os mais elevados níveis de expressão do IGF1R, em células de LLA-B ou LLA-T, se mostraram relacionados com os fenótipos mais imaturos (Estrov et al, 1991;Baier et al, 1992a;Baier et al, 1992b;Neely et al, 1992;Leverrier et al, 1999;Ogawa et al, 2000;Tu et al, 2000). Medyouf et al (2011) A interconexão das vias de sinalização intracelular contribui para que a insulina/IGFs atuem de maneira diferente em contextos celulares diferentes.…”

Section: O Sistema Igfunclassified

“…Como mencionado anteriormente, as IGFs e insulina são fatores de sobrevivência para um grande número de tipos celulares (Schofield e Engstrom, 1992), incluindo as células de LLA (Estrov et al, 1991;Baier et al, 1992a;Baier et al, 1992b;Neely et al, 1992). A IGFBP7 tem uma baixa afinidade de ligação a esses fatores, desta forma ela não compete com os receptores da insulina e IGFs, aumentando a meia-vida e as atividades mitogênicas destes fatores (Akaogi et al, 1996a;Oh et al, 1996).…”

Section: Igfbp7 Na Resistência a Diferentes Quimioterápicosunclassified

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Participação do IGFBP7 na interação leucemia-estroma e na resistência a quimioterapia

Laranjeira¹

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Section: O Sistema Igfunclassified

Section: Igfbp7 Na Resistência a Diferentes Quimioterápicosunclassified

Participação do IGFBP7 na interação leucemia-estroma e na resistência a quimioterapia

Laranjeira¹

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Expanding Beyond Genetic Subtypes in B-Cell Acute Lymphoblastic Leukemia: A Pathway-Based Stratification of Patients for Precision Oncology

Ulucan

2024

OMICS: A Journal of Integrative Biology

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Subclassification of B-acute lymphoblastic leukemia according to age, immunophenotype and microenvironment, predicts MRD risk in Mexican children from vulnerable regions

Romo-Rodríguez,

Zamora-Herrera,

López-Blanco

et al. 2024

Front. Oncol.

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IntroductionThe decisive key to disease-free survival in B-cell precursor acute lymphoblastic leukemia in children, is the combination of diagnostic timeliness and treatment efficacy, guided by accurate patient risk stratification. Implementation of standardized and high-precision diagnostic/prognostic systems is particularly important in the most marginalized geographic areas in Mexico, where high numbers of the pediatric population resides and the highest relapse and early death rates due to acute leukemias are recorded even in those cases diagnosed as standard risk.MethodsBy using a multidimensional and integrated analysis of the immunophenotype of leukemic cells, the immunological context and the tumor microenvironment, this study aim to capture the snapshot of acute leukemia at disease debut of a cohort of Mexican children from vulnerable regions in Puebla, Oaxaca and Tlaxcala and its potential use in risk stratification.Results and discussionOur findings highlight the existence of a distinct profile of ProB-ALL in children older than 10 years, which is associated with a six-fold increase in the risk of developing measurable residual disease (MRD). Along with the absence of CD34+ seminal cells for normal hematopoiesis, this ProB-ALL subtype exhibited several characteristics related to poor prognosis, including the high expression level of myeloid lineage markers such as MPO and CD33, as well as upregulation of CD19, CD34, CD24, CD20 and nuTdT. In contrast, it showed a trend towards decreased expression of CD9, CD81, CD123, CD13, CD15 and CD21. Of note, the mesenchymal stromal cell compartment constituting their leukemic niche in the bone marrow, displayed characteristics of potential suppressive microenvironment, such as the expression of Gal9 and IDO1, and the absence of the chemokine CXCL11. Accordingly, adaptive immunity components were poorly represented. Taken together, our results suggest, for the first time, that a biologically distinct subtype of ProB-ALL emerges in vulnerable adolescents, with a high risk of developing MRD. Rigorous research on potential enhancing factors, environmental or lifestyle, is crucial for its detection and prevention. The use of the reported profile for early risk stratification is suggested.

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Prognostic and Predictive Biomarkers in Precursor B-cell Acute Lymphoblastic Leukemia

Cited by 3 publications

References 83 publications

Participação do IGFBP7 na interação leucemia-estroma e na resistência a quimioterapia

Participação do IGFBP7 na interação leucemia-estroma e na resistência a quimioterapia

Expanding Beyond Genetic Subtypes in B-Cell Acute Lymphoblastic Leukemia: A Pathway-Based Stratification of Patients for Precision Oncology

Subclassification of B-acute lymphoblastic leukemia according to age, immunophenotype and microenvironment, predicts MRD risk in Mexican children from vulnerable regions

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