Prognostic and immunological role of Fam20C in pan-cancer

Liu, Xinpeng; Zhan, Yuanbo; Xu, Wenxia; Liu, Xiaoyao; Geng, Yawei; Liu, Lixue; Da, Junlong; Wang, Jianqun; Zhang, Xinjian; Jin, Han; Liu, Zhongshuang; Guo, Shouli; Zhang, Bin; Li, Ying

doi:10.1042/bsr20201920

Cited by 20 publications

(19 citation statements)

References 57 publications

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“…For example, a pan-cancer study showed that there was a significant different expression of NLRP3 in 15 different cancers, and it was used as an independent posterior factor of SKCM ( Ju et al, 2021 ). Similarly, when comparing the expression level of Fam20C in cancer tissues with that in neighboring normal tissues, we found a large variation across different kinds of cancers which indicated the different roles in different cancers ( Liu et al, 2021 ).…”

Section: Discussionmentioning

confidence: 73%

Pan-Cancer Analyses Reveal Oncogenic and Immunological Role of Dickkopf-1 (DKK1)

2021

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WNT signaling pathway inhibitor Dickkopf-1 (DKK1) is related to cancer progression; however, its diagnostic and prognostic potential have not been investigated in a pan-cancer perspective. In this study, multiple bioinformatic analyses were conducted to evaluate therapeutic value of DKK1 in human cancers. The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) project served as data resources. The Wilcoxon rank test was performed to evaluate the expression difference of DKK1 between cancer tissues and normal tissues. A Kaplan-Meier curve and Cox regression were used for prognosis evaluation. Single-sample gene set enrichment analysis (ssGSEA) was used to evaluate the association of DKK1 expression with the immune cell infiltration. The potential function of DKK1 was explored by STRING and clusterProfiler. We found that the expression level of DKK1 is significantly different in different cancer types. Importantly, we demonstrated that DKK1 is an independent risk factor in ESCA, LUAD, MESO, and STAD. Further analysis revealed that DKK1 had a large effect on the immune cell infiltration and markers of certain immune cells, such as Th1 and Th2 cells. PPI network analysis and further pathway enrichment analysis indicated that DKK1 was mainly involved in the WNT signaling pathway. Our findings suggested that DKK1 might serve as a marker of prognosis for certain cancers by affecting the WNT signaling pathway and tumor immune microenvironment.

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Section: Discussionmentioning

confidence: 73%

Pan-Cancer Analyses Reveal Oncogenic and Immunological Role of Dickkopf-1 (DKK1)

2021

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“…In this report, they also found an evident correlation between the elevated Fam20C expression and the progressed glioma malignancy, as well as the coherence between the elevated Fam20C expression and the disrupted immune response in the GBM microenvironment. Similarly, the work of Li et al in Bioscience Reports confirmed the widely and elevated expression of Fam20C among many cancer types, as well as its value for the detrimental prognosis in cancers, especially bladder urothelial carcinoma (BLCA), Brain Lower Grade Glioma (LGG) and stomach adenocarcinoma (STAD) [22]. Thus, both Du Furthermore, a strong correlation between Fam20C expression and T helper cell markers (Th1, Th2, Th9, Tfh and Th17) in BLCA, LGG and STAD was also found.…”

Section: The Roles Of Fam20c In Tumorogenesismentioning

confidence: 77%

“…Recent studies have identified Fam20C as a key gene for the progression of lung adenocarcinoma in the context of hypoxia [19], and the Fam20C inhibitor, FL-1607 as an inducer for the apoptosis and an inhibitor for the migration of breast cancer cells [20,21]. Since the correlation between the increased Fam20C expression and the cancers was emerging, Liu et al To fill the gap between the physiological and pathological roles of Fam20C, Liu et al analyzed Fam20C expression levels and the prognostic value in different types of cancers [22]. Combined the data from different databases, the Fam20C expression in cancers was significantly elevated, particularly in central nervous system (CNS) cancers, breast invasive carcinoma (BRCA), cervical squamous cell carcinoma (CESC), colorectal cancer, esophageal carcinoma (ESCA), head and neck squamous cell carcinoma (HNSC), lymphoma, liver hepatocellular carcinoma (LIHC), lung Downloaded from http://portlandpress.com/bioscirep/article-pdf/doi/10.1042/BSR20210040/910673/bsr-2021-0040c.pdf by guest on 10 May 2021 cancer, pancreatic adenocarcinoma (PAAD), prostate adenocarcinoma (PRAD) and thyroid carcinoma (THCA).…”

Section: The Roles Of Fam20c In Tumorogenesismentioning

confidence: 99%

From biomineralization to tumorogenesis—the expanding insight of the physiological and pathological roles of Fam20C

Wang

Liu

2021

Bioscience Reports

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Fam20C is a Golgi kinase phosphorylating the majority of the secreted proteins. In this decade, the roles of Fam20C has been largely disclosed in the loss-of function models. How the influence of the over-expressed Fam20C on cells or organs, and whether Fam20C was associated to tumorogensis still remain unknown. In the latest publication in Bioscience Reports, a group from the second affiliated hospital of Harbin Medical University established a correlation between the elevated Fam20C expression and the poor prognosis of multiple cancers. In addition, they also proposed the potential mechanisms how the increased Fam20C expression played a detrimental role in tumor progression by suggesting that the up-regulated Fam20C level impacted the infiltration of immune cells and the capability of cancer metastasism. To give an overview of the expanding knowledge of Fam20C involved in the physiological and pathological events, we first reviewed the history of Fam20C studies in this commentary, then, evaluated the correlation of the elevated Fam20C expression to the prognosis of multiple cancers, and finally, interpreted the perspectives that the Fam20C gain-of-function model was also critical for cancer therapy.

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“…FAM20C is widely expressed across many types of cancers compared with the adjacent normal tissues. Moreover, the FAM20C expression is positively associated with a poor prognosis in breast, lung, and colorectal cancers, as well as glioblastoma [ 32 , 33 ]. Our results have shown that A549 and H460 cells abundantly produced phosphorylated OPN.…”

Section: Discussionmentioning

confidence: 99%

Phosphorylated Osteopontin Secreted from Cancer Cells Induces Cancer Cell Motility

et al. 2021

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Osteopontin (OPN) plays a pivotal role in cancer cell invasion and metastasis. Although OPN has a large number of phosphorylation sites, the functional significance of OPN phosphorylation in cancer cell motility remains unclear. In this study, we attempted to investigate whether phosphorylated OPN secreted from cancer cells affect cancer cell migration. Quantitative PCR and Western blot analyses revealed that MDA-MB435S, A549, and H460 cells highly expressed OPN, whereas the OPN expression levels in H358, MIAPaca-2, and Panc-1 cells were quite low or were not detected. Compared with the cancer cell lines with a low OPN expression, the high OPN-expressing cancer cell lines displayed a higher cell migration, and the cell migration was suppressed by the anti-OPN antibody. This was confirmed by the OPN overexpression in H358 cancer cells with a low endogenous OPN. Phos-tag ELISA showed that phosphorylated OPN was abundant in the cell culture media of A549 and H460 cells, but not in those of MDA-MB435S cells. Moreover, the A549 and H460 cell culture media, as well as the MDA-MB435S cell culture media with a kinase treatment increased cancer cell motility, both of which were abrogated by phosphatase treatment or anti-OPN antibodies. These results suggest that phosphorylated OPN secreted from cancer cells regulates cancer cell motility.

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Prognostic and immunological role of Fam20C in pan-cancer

Cited by 20 publications

References 57 publications

Pan-Cancer Analyses Reveal Oncogenic and Immunological Role of Dickkopf-1 (DKK1)

Pan-Cancer Analyses Reveal Oncogenic and Immunological Role of Dickkopf-1 (DKK1)

From biomineralization to tumorogenesis—the expanding insight of the physiological and pathological roles of Fam20C

Phosphorylated Osteopontin Secreted from Cancer Cells Induces Cancer Cell Motility

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