Prognostic and Diagnostic Values of Circulating Tumor Cells and Tumor Markers for Lung Cancer

Liu, Xiaoqiang; Wang, Chenjie; Zhang, Liwen; Gu, Haidi; Yang, Jun; Wang, Ying; Tan, Jie

doi:10.7754/clin.lab.2020.200654

Cited by 4 publications

(2 citation statements)

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“…Evidence has shown that invasion may occur very early in the tumor process, and CTCs are released into circulation in the early phase of cancer. Lymph node infiltration is related to poor prognosis (28). Many researchers have emphasized the importance of detection of CTCs (31)(32)(33).…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have shown that pathological subtype, degree of differentiation, and clinical stage are closely correlated with prognosis in lung cancer ( 27 , 28 ). However, few studies have explored the ability of FR + CTC level to distinguish growth pattern subtypes, as this one has done, and we propose that this measure can be used a reference in determining the extent of surgical resection required in patients with early invasive adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

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Preoperative levels of folate receptor-positive circulating tumor cells in different subtypes of early-stage lung adenocarcinoma: Predictive value for determining extent of surgical resection

Zhou

Zhao

et al. 2023

Front. Oncol.

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BackgroundThe objective was to measure the correlations of preoperative levels of folate receptor-positive circulating tumor cells (FR+CTCs) with clinical characteristics and histologic subtype in early-stage lung adenocarcinoma, and to determine the predictive value of FR+CTC level in preoperative determination of the extent of surgical resection.Patients and methodsIn this retrospective, single-institution, observational study, preoperative FR+CTC levels were measured via ligand-targeted enzyme-linked polymerization in patients with early-stage lung adenocarcinoma. Receiver operating characteristic (ROC) analysis was used to identify the optimal cutoff value of FR+CTC level for prediction of various clinical characteristics and histologic subtypes.ResultsNo significant difference in FR+CTC level was observed among patients with adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and invasive adenocarcinoma (IAC) (P = 0.813). Within the non-mucinous adenocarcinoma group, no difference was observed among patients with tumors whose predominant growth patterns were lepidic, acinar, papillary, micropapillary, solid, and complex gland (P = 0.053). However, significant differences in FR+CTC level were observed between patients with and without the micropapillary subtype [11.21 (8.22-13.61) vs. 9.85 (7.43-12.63), P = 0.017], between those with and without the solid subtype [12.16 (8.27-14.90) vs. 9.87 (7.50-12.49), P = 0.022], and between those with any of the advanced subtypes (micropapillary, solid, or complex glands) vs. none of these [10.48 (7.83-13.67) vs. 9.76 (7.42-12.42), P = 0.032]. FR+CTC level was also correlated with degree of differentiation of lung adenocarcinoma (P = 0.033), presence of visceral pleural invasion (VPI) of lung carcinoma (P = 0.003), and lymph node metastasis of lung carcinoma (P = 0.035).ConclusionFR+CTC level is of potential predictive value in determining the presence of aggressive histologic patterns (micropapillary, solid, and advanced subtypes), degree of differentiation, and occurrence of VPI and lymph node metastasis in IAC. Measurement of FR+CTC level combined with intraoperative frozen sections may represent a more effective method of guiding resection strategy in cases of cT1N0M0 IAC with high-risk factors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Preoperative levels of folate receptor-positive circulating tumor cells in different subtypes of early-stage lung adenocarcinoma: Predictive value for determining extent of surgical resection

Zhou

Zhao

et al. 2023

Front. Oncol.

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The clinical significance of circulating tumor cells and T lymphocyte subtypes in pancreatic cancer patients

Xing

Zhang²,

Qin

et al. 2022

Bioengineered

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Liquid biopsy techniques and lung cancer: diagnosis, monitoring and evaluation

Ren,

Fei,

Qiu

et al. 2024

J Exp Clin Cancer Res

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Lung cancer stands as the most prevalent form of cancer globally, posing a significant threat to human well-being. Due to the lack of effective and accurate early diagnostic methods, many patients are diagnosed with advanced lung cancer. Although surgical resection is still a potential means of eradicating lung cancer, patients with advanced lung cancer usually miss the best chance for surgical treatment, and even after surgical resection patients may still experience tumor recurrence. Additionally, chemotherapy, the mainstay of treatment for patients with advanced lung cancer, has the potential to be chemo-resistant, resulting in poor clinical outcomes. The emergence of liquid biopsies has garnered considerable attention owing to their noninvasive nature and the ability for continuous sampling. Technological advancements have propelled circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), extracellular vesicles (EVs), tumor metabolites, tumor-educated platelets (TEPs), and tumor-associated antigens (TAA) to the forefront as key liquid biopsy biomarkers, demonstrating intriguing and encouraging results for early diagnosis and prognostic evaluation of lung cancer. This review provides an overview of molecular biomarkers and assays utilized in liquid biopsies for lung cancer, encompassing CTCs, ctDNA, non-coding RNA (ncRNA), EVs, tumor metabolites, TAAs and TEPs. Furthermore, we expound on the practical applications of liquid biopsies, including early diagnosis, treatment response monitoring, prognostic evaluation, and recurrence monitoring in the context of lung cancer.

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Prognostic and Diagnostic Values of Circulating Tumor Cells and Tumor Markers for Lung Cancer

Cited by 4 publications

References 0 publications

Preoperative levels of folate receptor-positive circulating tumor cells in different subtypes of early-stage lung adenocarcinoma: Predictive value for determining extent of surgical resection

Preoperative levels of folate receptor-positive circulating tumor cells in different subtypes of early-stage lung adenocarcinoma: Predictive value for determining extent of surgical resection

The clinical significance of circulating tumor cells and T lymphocyte subtypes in pancreatic cancer patients

Liquid biopsy techniques and lung cancer: diagnosis, monitoring and evaluation

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