Prognostic and diagnostic significance of Cavin 2 in lung adenocarcinoma

Wang, Xianguo; Arcani, Diana Maria Cespedes; Zhao, Jingping; Xu, Meifeng; Zhou, Xuefeng; Yang, Yibin

doi:10.5114/aoms.2019.85347

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…The association between biomarkers and tumors has aroused much attention [34,35]. In order to comprehensively evaluate the linear relationship between blood lipid pro les and lung cancer risk, we explored the association between abnormal tumor markers and lipid pro les among lung cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Independent Associations Between Blood Lipid Profiles and Lung Cancer Risk

Zhao

et al. 2021

Preprint

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Introduction: Dyslipidemia is a common intermediate aggravating factor of various cancers, but the relationship between blood lipid profiles and lung cancer remains unclear. This study was performed to assess the non-linear and linear relationships between them.Material and methods: We enrolled 1593 newly diagnosed lung cancer patients and 1593 age- and sex-matched healthy controls between 2017 and 2019. Biochemical indicators, including lipid profiles and tumor markers, were collected. Odds ratios and 95% conﬁdence intervals were calculated using conditional logistic regression analysis. The restricted cubic spline analysis and multiple linear regression were used to explore the non-linear and linear associations.Results: Lung cancer patients had lower values for total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). After multivariate adjustment, hyper-TC and low-HDL-C were associated with lung cancer risk. In addition, non-linear relationships were identified between lung cancer risk and TC/HDL-C. Multiple linear regression analyses showed that triglycerides were signiﬁcantly associated with squamous cell carcinoma antigen (SCC). As well, HDL-C was signiﬁcantly associated with neuron-specific enolase (NSE), cytokeratin 19 fragments (CYFRA21-1), SCC, and tumor-associated antigen 125 (CA-125). Signiﬁcant linear trends were observed between increasing triglyceride quartiles and hyper-NSE/hyper-CYFRA21-1, and between increasing HDL-C quartiles and hyper-NSE/hyper-CYFRA21-1/hyper-CA-125. Conclusions: Lipid levels were significantly lower in lung cancer patients, and there were negative non-linear associations of TC and HDL-C with lung cancer risk. In addition, there were negative linear trends across TG and HDL-C quartiles for the risk of abnormal tumor markers among lung cancer patients.

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Section: Discussionmentioning

confidence: 99%

Independent Associations Between Blood Lipid Profiles and Lung Cancer Risk

Zhao

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…Lung cancer is the most prevalent and fatal malignancy worldwide. Its occurrence, development, and clinical prognosis are related to a variety of factors including smoking, environment, air pollution, diet, and gene expression [1][2][3][4][5][6]. Many studies have confirmed that, biologically, cancer is a metabolic disease [7,8], and thus nutrition-and metabolism-regulating therapies have become new treatment strategies for tumours.…”

Section: Introductionmentioning

confidence: 99%

Determination of multiple vitamins in 178 patients undergoing chemotherapy for lung cancer

et al. 2021

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IntroductionThe aim of the study was to investigate the changes in serum concentrations of nine vitamins in patients undergoing chemotherapy for lung cancer and explore their clinical values and influencing factors.Material and methodsPatients receiving chemotherapy for lung cancer in our centre from February 2018 to May 2020 were enrolled in this study. Serum concentrations of the nine vitamins including vitamins A, D, E, B9, B12, B1, C, B2, and B6 were measured in all subjects, and the changes in the concentrations of these vitamins were compared before and after 2 cycles of chemotherapy. In addition, the potential correlations of serum vitamin levels with age, gender, pathological type, and disease status were analysed.ResultsIn the 178 patients with lung cancer, there were different degrees of vitamin A, vitamin D, vitamin C, and in particular, vitamin B2 deficiencies. Before chemotherapy, the concentrations of vitamin A and vitamin C were significantly different between males and females and among patients in different clinical stages (both p < 0.05), the concentrations of vitamin C and vitamin B2 significantly differed among different pathological types of lung cancer (p < 0.05), and vitamin D level was significantly related to the disease status (p < 0.05). In addition, the proportion of vitamin B2 deficiency differed significantly among different pathological types (p < 0.05). There were significant differences in the concentrations of vitamins D, C, and B2 before and after chemotherapy (all p < 0.05). There was a correlation between the change of serum vitamin B1 concentration before and after chemotherapy and the change of body mass index (p < 0.05).ConclusionsDuring chemotherapy, lung cancer patients are more likely to develop vitamins A, D, C, and B2 deficiencies. Different vitamin deficiencies are related to gender, clinical stage, pathological type, and disease status. Vitamin determination and reasonable supplementation of nutrients in patients undergoing chemotherapy for lung cancer can help improve the nutritional status and increase chemotherapy tolerance.

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Prognostic and diagnostic significance of Cavin 2 in lung adenocarcinoma

Cited by 2 publications

References 25 publications

Independent Associations Between Blood Lipid Profiles and Lung Cancer Risk

Independent Associations Between Blood Lipid Profiles and Lung Cancer Risk

Determination of multiple vitamins in 178 patients undergoing chemotherapy for lung cancer

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