2016
DOI: 10.1038/bjc.2015.463
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Prognostic and diagnostic potential of miR-146a in oesophageal squamous cell carcinoma

Abstract: Background:Accumulating evidence indicates that dysregulated microRNA-146a (miR-146a) is involved in tumour genesis and cancer progression. We aimed to evaluate its expression level and the potential for the diagnosis and prognosis in oesophageal squamous cell cancer (ESCC).Methods:We examined miR-146a expression in 62 pairs of ESCC cancerous and matched paracancerous tissue, 115 formalin-fixed paraffin-embedded (FFPE) tissue samples and serum samples from 154 ESCC patients and 154 healthy volunteers using qua… Show more

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Cited by 48 publications
(29 citation statements)
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References 46 publications
(62 reference statements)
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“…Expression level of miR-146a-5p was downregulated in ESCC tissues compared with the adjacent normal tissues and it could predict overall survival (OS) and progression-free survival (PFS) of ESCC patients, which has been reported in our previous article (Wang et al , 2016a). The invasiveness of ESCC cells (EC 9706 and Eca 109) were examined after transfection.…”
Section: Resultssupporting
confidence: 55%
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“…Expression level of miR-146a-5p was downregulated in ESCC tissues compared with the adjacent normal tissues and it could predict overall survival (OS) and progression-free survival (PFS) of ESCC patients, which has been reported in our previous article (Wang et al , 2016a). The invasiveness of ESCC cells (EC 9706 and Eca 109) were examined after transfection.…”
Section: Resultssupporting
confidence: 55%
“…In this way, miRNAs inhibit the expression of specific target genes (Pichler and Calin, 2015). Accumulating evidence has shown that miRNAs can participate in tumourigenesis, progression and metastasis either as oncogenes or tumour suppressors and have potential as diagnostic, prognostic and therapeutics factors in cancer medicine (Sita-Lumsden et al , 2013; Krzeszinski et al , 2014; Wang et al , 2016a). …”
mentioning
confidence: 99%
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“…They bind the 3’-untranslated region (UTR) of various target mRNAs, enhancing their degradation or their translational repression, leading to multiple biological consequences [5,6]. In several cancers, miR-146a (encoded on chromosome 5q33) is dysregulated and acts as an oncogene [79] or as a tumor-suppressor gene [1014]. Meanwhile, Snail, an inducer of the epithelial to mesenchymal transition, induces miR-146a , stabilizing Wnt activity and attenuating tumorigenicity [15].…”
Section: Introductionmentioning
confidence: 99%
“…This observation is reflected by the global downregulation of miR-146 in ESCC tissues compared to tumor adjacent tissues, likely due to the effect of this negative feedback loop. 71 Even though, the oncogenic role of NF-κB is well known, NF-κB has also shown to activate miRNAs that possess both tumor-suppressive and tumor-promoting roles in a context-dependent manner. For instance, miR-31 has been shown to be a direct target of NF-κB in skin keratinocytes leading to hyperproliferation in psoriatic epidermis.…”
Section: Non-coding Rnas Regulating/ Regulated By Nf-κb Pathway In Esccmentioning
confidence: 99%