Prognostic and clinicopathological value of <scp>circPVT1</scp> in human cancers: A meta‐analysis

Lin, Zhengjun; Tang, Xianzhe; Wang, Lu; Lin, Ling

doi:10.1002/cnr2.1385

Cited by 6 publications

(5 citation statements)

References 42 publications

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“… 30 Furthermore, Lin et al proposed that high circPVT1 expression is correlated with poor prognosis in malignancies. 31 Chao et al discovered that circSMARCA5 is a promising biomarker in human cancers, which may assist in the management of cancer patients in the future. 32 Exploring the potential of circRNAs as biomarkers can provide valuable information for clinical decision‐making.…”

Section: Discussionmentioning

confidence: 99%

“…CircRNA CDR1as, according to Zou et al, is a reliable prognostic and diagnostic biomarker in solid tumors 30 . Furthermore, Lin et al proposed that high circPVT1 expression is correlated with poor prognosis in malignancies 31 . Chao et al discovered that circSMARCA5 is a promising biomarker in human cancers, which may assist in the management of cancer patients in the future 32 .…”

Section: Discussionmentioning

confidence: 99%

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Circular RNA MYLK as a prognostic biomarker in patients with cancers: A systematic review and meta‐analysis

et al. 2022

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Background Circular RNA (circRNA) myosin light chain kinase (circMYLK) has recently received increasing attention in cancer biology. Several studies have suggested that circMYLK expression is linked to prognosis and clinicopathological characteristics of various malignancies. Aims This study was carried out to systematically review the impact of circMYLK on the progression of multiple cancers and assess the significance of circMYLK in the prognosis and clinicopathological features of the patients. Methods PubMed, Web of Science, and Embase were systematically searched until July 2, 2021. For qualitative synthesis, the signaling pathways of circMYLK in the progression of different cancers were summarized. Regarding the meta‐analysis, overall survival (OS) and eight clinicopathological characteristics of patients with cancers were addressed. Odds ratios (ORs) and hazard ratios (HRs) were calculated to assess the association of circMYLK with prognostic and clinicopathological features. Results Twelve studies investigating the role of circMYLK in cancer progression met the inclusion criteria. Among these, seven studies investigated the prognostic significance of circMYLK, and nine studies ascertained the clinicopathological importance of circMYLK in patients with various malignancies. CircMYLK acts as a tumor promoter circRNA, leading to migration, proliferation, invasion, and metastasis of neoplastic cells and inhibiting their apoptosis through interaction with several miRNAs and corresponding downstream signaling pathways. Overexpression of circMYLK was correlated with poor OS (HR = 1.75; 95% confidence interval [CI] 1.52–2.02) and larger tumor size (OR = 2.90; 95% CI 1.03–8.15), higher T stage (OR = 2.49; 95% CI 1.20–5.18), lymph node metastasis (OR = 2.55; 95% CI 1.41–4.62), and higher TNM stage (OR = 4.62; 95% CI 2.99–7.14). Conclusions CircMYLK is involved in the progression of numerous cancers via different signaling pathways. This circRNA can serve as a promising prognostic biomarker for several types of malignancies. Furthermore, high expression of circMYLK is associated with advanced clinicopathological characteristics in various tumors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Circular RNA MYLK as a prognostic biomarker in patients with cancers: A systematic review and meta‐analysis

et al. 2022

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“…Upregulation of circPVT1 has been associated with decreased survival of patients with diverse cancer types, demonstrating the role of this circRNA as a prognostic marker. Two recent meta-analyses have indicated the importance of circPVT1 levels in prediction of malignant behavior of different types of neoplasms ( 53 , 54 ). Further proofs for participation of circPVT1 in the carcinogenesis have come from the observed association between its levels in tumors and clinical data including TNM stage, tumor size, and lymph node positivity.…”

Section: Discussionmentioning

confidence: 99%

A Concise Review on the Role of CircPVT1 in Tumorigenesis, Drug Sensitivity, and Cancer Prognosis

et al. 2021

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CircPVT1 (hsa_circ_0001821) is a cancer-related circular RNA (circRNA) that originated from a genomic locus on chromosome 8q24. This locus has been previously found to encode the oncogenic long non-coding RNA PVT1. Expression of this circRNA has been found to be upregulated in diverse neoplastic conditions. CircPVT1 acts as a sponge for miR-125a, miR-125b, miR-124-3p, miR-30a-5p, miR-205-5p, miR‐423‐5p, miR‐526b, miR-137, miR-145-5p, miR-497, miR-30d/e, miR-455-5p, miR-29a-3p, miR-204-5p, miR-149, miR-106a-5p, miR-377, miR-3666, miR-203, and miR-199a-5p. Moreover, it can regulate the activities of PI3K/AKT, Wnt5a/Ror2, E2F2, and HIF-1α. Upregulation of circPVT1 has been correlated with decreased survival of patients with different cancer types. In the current review, we explain the oncogenic impact of circPVT1 in different tissues based on evidence from in vitro, in vivo, and clinical investigations.

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“… 3–5 circRNA plasmacytoma variant translocation 1 (circPVT1), transcribed from the long noncoding RNA region with PVT1 locus on chromosome 8q24, is upregulated to drive the development of various cancers. 6 , 7 PVT1 from online data analysis was abnormally expressed in BLCA. However, the role of circPVT1 in BLCA is still unknown.…”

Section: Introductionmentioning

confidence: 95%

circPVT1 Inhibits the Proliferation and Aids in Prediction of the Prognosis of Bladder Cancer

Zhou,

Cui,

Zhu

et al. 2024

PGPM

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Background: Circular RNA PVT1 (circPVT1) is aberrantly expressed in several cancers, but its functional role and clinical relevance in bladder urothelial carcinoma (BLCA) remain unknown. This study aimed to identify the expression level of circPVT1 in BLCA and investigated its functional relevance with BLCA progression both in vitro and in vivo. Methods: GEPIA, UALCAN, and OncoLnc were referred to presented data. Quantitative real-time PCR (qPCR) was used for the measurement of transnational expression of genes in BLCA specimens and cell lines. Immunohistochemistry (IHC) and fluorescence in situ hybridization analysis (FISH) assays were performed to detect HER2 amplification, Pearson's correlation analysis to analyze the correlation between circPVT1 expression and clinical characteristics, Cox regression and K-M survival analyses to analyze prognostic factors. A nomogram was constructed for predicting prognosis. The proliferation of cells was measured by CCK-8 and colony formation assay, and the proliferation in vivo was evaluated using nude mouse models. qPCR was used to detect the expression of proliferation-related genes. Results: circPVT1 was but mRNA PVT1 was not significantly overexpressed in BLCA. A high circPVT1 expression was associated with a better survival and negative HER2, but not with age, gender, and T stage. circPVT1 was an independent prognostic factor for the overall survival of BLCA patients. Knocking down circPVT1 promoted BLCA proliferation in vitro and in vivo. Knocking down circPVT1 upregulated ERBB2, MKI67, and PCNA expression and downregulated TP53 expression, but exerted no influence on CCND1 and CCNB1 expression. Conclusion: circPVT1 is a tumor suppressor and novel prognostic biomarker for BLCA.

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Prognostic and clinicopathological value of circPVT1 in human cancers: A meta‐analysis

Cited by 6 publications

References 42 publications

Circular RNA MYLK as a prognostic biomarker in patients with cancers: A systematic review and meta‐analysis

Circular RNA MYLK as a prognostic biomarker in patients with cancers: A systematic review and meta‐analysis

A Concise Review on the Role of CircPVT1 in Tumorigenesis, Drug Sensitivity, and Cancer Prognosis

circPVT1 Inhibits the Proliferation and Aids in Prediction of the Prognosis of Bladder Cancer

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