Prognostic and clinicopathological insights of phosphodiesterase 9A gene as novel biomarker in human colorectal cancer

Abstract

Background PDE9A (Phosphodiesterase 9A) plays an important role in proliferation of cells, their differentiation and apoptosis via intracellular cGMP (cyclic guanosine monophosphate) signaling. The expression pattern of PDE9A is associated with diverse tumors and carcinomas. Therefore, PDE9A could be a prospective candidate as a therapeutic target in different types of carcinoma. The study presented here was designed to carry out the prognostic value as a biomarker of PDE9A in Colorectal cancer (CRC). The present study integrated several cancer databases with in-silico techniques to evaluate the cancer prognosis of CRC. Results The analyses suggested that the expression of PDE9A was significantly down-regulated in CRC tissues than in normal tissues. Moreover, methylation in the DNA promoter region might also manipulate PDE9A gene expression. The Kaplan–Meier curves indicated that high level of expression of PDE9A gene was associated to higher survival in OS, RFS, and DSS in CRC patients. PDE9A demonstrated the highest positive correlation for rectal cancer recurrence with a marker gene CEACAM7. Furtheremore, PDE9A shared consolidated pathways with MAPK14 to induce survival autophagy in CRC cells and showed interaction with GUCY1A2 to drive CRPC. Conclusions Overall, the prognostic value of PDE9A gene could be used as a potential tumor biomarker for CRC.

Once upon a Testis: The Tale of Cyclic Nucleotide Phosphodiesterase in Testicular Cancers

“…Interference of cAMP/cGMP signaling pathway has been shown to be linked to tumorigenesis [155,197] and PDEs overexpression has been already described in several cancer types such happened for PDE11A and PDE8B, in adrenal hyperplasia/adenomas [162,198,199]. Indeed some PDEs have been already proposed as a potential biomarker for different tumoral contests [200][201][202][203][204] and we have proposed PDE8B as a promising biomarker for Leydig cell tumours. We believe that multi-omics will be useful to deeply analyze PDEs expression and activity for the translation of such findings in clinical practice.…”

Hypothetical protein predicted to be tumor suppressor: a protein functional analysis

“…VHL tumor suppressor protein can play a role in tumor suppression in multiple ways and the most common of them is targeting the HIF that mediated tumor suppression activity through polyubiquitylation and proteasomal degradation [ 66 ]. The major contribution of pVHL is to suppress clear-cell renal cell carcinoma in kidney cancer [ 66 , 67 ] and phosphodiesterase 9A gene as novel biomarker in human colorectal cancer [ 68 ].…”

A Regulatory Network Analysis of the Importance of USP15 in Breast Cancer Metastasis and Prognosis

“…The p value cutoff was 0.05. The student's t -test was used to generate a p value for expression or pathological stage analysis [ 37 , 38 ].…”

“…GeneMANIA. GeneMANIA (http://www.genemania .org) is a user-friendly website that provides information on protein and genetic interactions, pathways, coexpression, colocalization, and protein domain similarity of submitted genes [37,41].…”