Prognostic analysis of early-stage squamous cell carcinoma of the vulva

Abstract

AimThe aim of this study was to analyze prognostic factors of early-stage squamous cell carcinoma of the vulva.MethodsA retrospective analysis was conducted on 35 patients who were treated for early-stage squamous cell carcinoma of the vulva at Sun Yat-sen University Cancer Center from January 1980 to December 2005. The Statistical Package for Social Science (SPSS) was used to compare the different strategies of operation and to analyze the prognostic factors.ResultsThirty-five patients had early-stage squamous cell carcinoma of the vulva. Of these cases, 26 were well differentiated, seven were moderately differentiated, and two were poorly differentiated. The five-year survival rate was 77.1%. Five cases were in FIGO stage 1a and 30 cases were in stage 1b; median survival times were 182.3 months and 152.5 months, and the five-year survival rates were 100% and 81.5% (P >0.05), respectively. The five-year survival of the patients who underwent local excision; radical vulvectomy and en bloc resection of inguinofemoral lymphadenectomy; orradical vulvectomyen bloc resection of inguinofemoral lymphadenectomy, and pelvic lymph nodes was 50%, 81.8%, and 83.9%, respectively. For these cases, 74.3% of the tumors were medial while 25.7% were lateral, and the five-year survival rates of patients according to tumor location were 87.0% and 64.8% (P <0.05), respectively. The inguinal lymph node not increased and active were 16 cases (45.7%), and increased, active and hard were 17 cases (48.6%), and syncretic were two cases (5.7%), five-year survival rates were 73.3%, 92.9% and 50% (P <0.05), respectively. Of these cases, 74.3% of the tumors were cauliflower-like and 25.7% were nodular; five-year survival rates by tumor type were 91.3% and 66.7% (P <0.05), respectively.ConclusionsFor patients with early-stage squamous cell carcinoma of the vulva, surgical operation is the primary, yet the best, treatment. The related prognostic factors were tumor location (lateral/medial), stage, gross morphology, and clinical state of the inguinal lymph node.

Diagnostic Difficulties in Pathological Laboratories in Developing Countries: A Case Report of Differentiated Squamous Cell Carcinoma in a Young Togolese Woman

“…Usually, it is the low potential oncogenic papillomavirus types 6, 11, 42, and 55 which are found in the anogenital region [ 6 ]. The poorly differentiated carcinoma due to HPV is consistent with the opinion of Xu et al and others who think that the papillomavirus is the instrument of pathology of undifferentiated vulva lesions [ 7 ].…”

Diagnosis, Therapy and Follow-up Care of Vulvar Cancer and its Precursors. Guideline of the DGGG and DKG (S2k-Level, AWMF Registry Number 015/059, November 2015

“…Established prognostic factors for vulvar cancer include the tumor stage, the presence of inguinal or pelvic lymph node metastasis [28][29][30][31][32][33][34][35][36][37]; the size of regional lymph node metastases, the presence of extracapsular growth and the number of lymph nodes with metastatic disease [30,31,35,36,[38][39][40][41][42][43][44]. The individual criteria for tumors ≥ stage pT1b are listed in l " Table 4.…”