Prognostic alternative splicing signature in cervical squamous cell carcinoma

Wu, Huayu; Li, Qi-qi; Liang, Liang; Qiu, Lanlan; Wei, Hongwei; Huang, Bing-ying; Chen, Gang; He, Rong‐Quan; Huang, Zhi‐Guang; Hou, Wei; Hu, Qiping; Pan, Shang‐Ling

doi:10.1049/iet-syb.2019.0095

Cited by 5 publications

(1 citation statement)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, we created an immune-based prognostic signature to monitor the immune status and assess the prognosis for cervical cancer patients. Previously, Wu HY et al (2020) have constructed a prognostic index based on percent-splice-in values in SCC [ 49 ]. Eun Jung Kwon et al (2020) have explored genomic alterations and developed a risk index model that can monitor HPV- related bladder cancer [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Immunogenomic Identification for Predicting the Prognosis of Cervical Cancer Patients

Wang

Vattai

Vilsmaier

et al. 2021

IJMS

View full text Add to dashboard Cite

Cervical cancer is primarily caused by the infection of high-risk human papillomavirus (hrHPV). Moreover, tumor immune microenvironment plays a significant role in the tumorigenesis of cervical cancer. Therefore, it is necessary to comprehensively identify predictive biomarkers from immunogenomics associated with cervical cancer prognosis. The Cancer Genome Atlas (TCGA) public database has stored abundant sequencing or microarray data, and clinical data, offering a feasible and reliable approach for this study. In the present study, gene profile and clinical data were downloaded from TCGA, and the Immunology Database and Analysis Portal (ImmPort) database. Wilcoxon-test was used to compare the difference in gene expression. Univariate analysis was adopted to identify immune-related genes (IRGs) and transcription factors (TFs) correlated with survival. A prognostic prediction model was established by multivariate cox analysis. The regulatory network was constructed and visualized by correlation analysis and Cytoscape, respectively. Gene functional enrichment analysis was performed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). A total of 204 differentially expressed IRGs were identified, and 22 of them were significantly associated with the survival of cervical cancer. These 22 IRGs were actively involved in the JAK-STAT pathway. A prognostic model based on 10 IRGs (APOD, TFRC, GRN, CSK, HDAC1, NFATC4, BMP6, IL17RD, IL3RA, and LEPR) performed moderately and steadily in squamous cell carcinoma (SCC) patients with FIGO stage I, regardless of the age and grade. Taken together, a risk score model consisting of 10 novel genes capable of predicting survival in SCC patients was identified. Moreover, the regulatory network of IRGs associated with survival (SIRGs) and their TFs provided potential molecular targets.

show abstract

Section: Discussionmentioning

confidence: 99%